Laurence-Moon Syndrome

An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)

Synonym
Laurence-Moon-Biedl Syndrome
Laurence-Moon Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	64 (91.43)	23.3326
1990's	5 (7.14)	12.5806
2000's	0 (0.00)	18.1394
2010's	0 (0.00)	28.8240
2020's	1 (1.43)	9.53

Drug	Relationship Strength	Studies
chlorine	low	1
glycerol	low	29
uric acid	low	1
chloroquine	low	1
2-propanol	low	2
metyrapone	low	1
estriol	low	1
aldosterone	low	1
estrone	low	1
lysine	low	1
tyrosine	low	1
leucine	low	1
phenylalanine	low	1
ornithine	low	1
arginine	low	1
betamethasone	low	1
perchloric acid	low	1
perchlorate	low	1
proline	low	1
technetium tc 99m pentetate	low	1
retinol	low	3
enclomiphene	low	2
succimer	low	1
17-ketosteroids	low	3
deamino arginine vasopressin	low	1
pituitrin	low	2
sodium glutamate	low	1
technetium tc 99m dimercaptosuccinic acid	low	1
eye	low	6

Protein Targets (357)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
RAR-related orphan receptor gamma	3	0	0	3
GLI family zinc finger 3	8	0	0	8
AR protein	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	4	0	0	4
estrogen nuclear receptor alpha	10	0	0	10
peroxisome proliferator-activated receptor delta	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Glutamate receptor 2	3	0	0	3
glucocorticoid receptor [Homo sapiens]	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
geminin	4	0	0	4
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	4	0	0	4
phosphopantetheinyl transferase	3	0	0	3
NFKB1 protein, partial	2	0	0	2
GLS protein	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	1	0	0	1
pregnane X receptor	2	0	0	2
progesterone receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
estrogen-related nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
IDH1	2	0	0	2
aryl hydrocarbon receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
galanin receptor type 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Bile salt export pump	0	5	0	5
Glucocorticoid receptor	0	4	0	4
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	2	0	2
ORF73	0	0	1	1
Carbonic anhydrase 1	0	3	0	5
Carbonic anhydrase 2	0	3	0	5
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 15	0	1	0	3
PPM1D protein	1	0	0	1
TDP1 protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Interferon beta	2	0	0	2
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	3	0	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	0	1	1	2
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Ataxin-2	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
USP1 protein, partial	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
glp-1 receptor, partial	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Smad3	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Epidermal growth factor receptor	0	1	0	1
Estrogen receptor	0	6	1	8
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Substance-K receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	6	0	6
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	3	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
thyroid hormone receptor beta isoform 2	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
endonuclease IV	1	0	0	1
ATAD5 protein, partial	1	0	0	1
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
nonstructural protein 1	1	0	0	1
G	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Steryl-sulfatase	0	1	0	1
Aromatase	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Mu-type opioid receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Mu-type opioid receptor	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Cytochrome P450 1B1	0	1	0	1
GABA theta subunit	3	0	0	3
Inositol hexakisphosphate kinase 1	1	0	0	1
Estrogen receptor beta	0	1	1	3
Ghrelin O-acyltransferase	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	4
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase 9	0	1	0	3
Sodium/iodide cotransporter	0	1	0	1
Luciferase	1	0	0	1
peripheral myelin protein 22	2	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	2
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 6	0	0	0	2
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Carbonic anhydrase 7	0	0	0	2
Carbonic anhydrase	0	0	0	2
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	1	0	0	1
acetylcholinesterase	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Nuclear receptor ROR-gamma	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research

Studies (70)

Protein Targets (357)

Laurence-Moon Syndrome

Synonyms(2)

Research

Studies (70)

Drugs Studied (44)

Protein Targets (357)