Page last updated: 2024-09-27

Ketron-Goodman Disease

A generalized or disseminated form of pagetoid reticulosis. Some authors consider it to be a primary cutaneous aggressive epidermotrophic CD8+ T-Cell lymphoma.

Synonyms(4)

Synonym
Ketron-Goodman Disease
Woringer-Kolopp Disease
Pagetoid Reticulosis
Woringer Kolopp Disease

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's6 (85.71)28.8240
2020's1 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
urea0low10
prednisone0low10
zidovudine0low10
etoposide0low10
imiquimod0low10
bexarotene0low10
methotrexate0low10
tretinoin0low10
alitretinoin0low10
clobetasol0low20

Protein Targets (340)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Ferritin light chain3003
Chain A, Cruzipain2002
Luciferase3003
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma5005
SMAD family member 24004
SMAD family member 34004
TDP1 protein9009
GLI family zinc finger 38008
Microtubule-associated protein tau3003
AR protein9009
aldehyde dehydrogenase 1 family, member A15005
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor5005
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha8008
pregnane X nuclear receptor8008
estrogen nuclear receptor alpha100010
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma6006
euchromatic histone-lysine N-methyltransferase 23003
thyroid stimulating hormone receptor4004
Histone H2A.x5005
retinoic acid receptor alpha isoform 10101
vitamin D3 receptor isoform VDRA5005
thyroid hormone receptor beta isoform 27007
retinoic acid receptor RXR-alpha isoform a0101
nuclear factor erythroid 2-related factor 2 isoform 19009
nuclear receptor ROR-gamma isoform 14004
Voltage-dependent calcium channel gamma-2 subunit5005
Renin0011
Cellular tumor antigen p537007
Cytochrome P450 1A20213
Retinoic acid receptor alpha05615
Retinoic acid receptor beta05615
Retinoic acid receptor alpha0235
Retinoic acid receptor gamma 05615
Retinoic acid receptor gamma0134
Glutamate receptor 25005
Retinoic acid receptor RXR-alpha06615
Retinoic acid receptor beta0134
Nuclear receptor subfamily 4 group A member 10011
Cellular retinoic acid-binding protein 20022
Retinoic acid receptor RXR-alpha0257
Retinoic acid receptor RXR-beta05510
Retinoic acid receptor RXR-beta0167
Retinoic acid receptor RXR-gamma0167
Type-1 angiotensin II receptor0022
Cellular retinoic acid-binding protein 10203
Retinoic acid receptor RXR-gamma05510
Type-2 angiotensin II receptor0022
Nuclear receptor ROR-gamma1124
Oxysterols receptor LXR-beta0022
Cellular retinoic acid-binding protein 10022
Retinoic acid receptor RXR-alpha0022
Oxysterols receptor LXR-alpha0022
Chain A, Beta-lactamase2002
bromodomain adjacent to zinc finger domain 2B2002
geminin6006
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Fumarate hydratase1001
USP1 protein, partial3003
PPM1D protein1001
caspase 7, apoptosis-related cysteine protease4004
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein3003
glucocorticoid receptor [Homo sapiens]5005
farnesoid X nuclear receptor4004
G2002
polyprotein1001
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-34004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 63003
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear receptor subfamily 1, group I, member 22002
Caspase-73003
Bloom syndrome protein isoform 13003
caspase-33003
heat shock protein beta-13003
peripheral myelin protein 225005
histone acetyltransferase KAT2A isoform 13003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Cytochrome P450 26A10101
Bile salt export pump0606
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Cytochrome P450 3A40213
Nuclear receptor subfamily 4 group A member 20011
Spike glycoprotein3003
Sigma non-opioid intracellular receptor 10101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10708
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Cytochrome P450 26B10101
cytochrome P450 2C9, partial2002
aryl hydrocarbon receptor3003
glp-1 receptor, partial1001
67.9K protein2002
LMP1 [Human herpesvirus 4]0001
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
DNA polymerase iota isoform a (long)4004
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10203
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0112
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30203
Glutamate receptor ionotropic, NMDA 3A0001
cytochrome P450 2D61001
DNA polymerase beta2002
lamin isoform A-delta103003
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Adenosine receptor A2a0202
7,8-dihydro-8-oxoguanine triphosphatase0101
Toll-like receptor 80011
Toll-like receptor 70011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
acid sphingomyelinase1001
dopamine D1 receptor1001
thioredoxin reductase2002
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase3003
ATAD5 protein, partial1001
Thymidylate synthase 0101
alpha-galactosidase1001
IDH11001
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 12002
survival motor neuron protein isoform d2002
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80002
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110002
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
ATP-dependent phosphofructokinase3003
pregnane X receptor2002
thioredoxin glutathione reductase2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Chain A, Nuclear Receptor ROR-beta0101
GLS protein1001
regulator of G-protein signaling 41001
nonstructural protein 11001
Parkin1001
thyroid hormone receptor beta isoform a1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Cytochrome P450 2D60011
60 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Alpha-1D adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Mitogen-activated protein kinase 10101
Indoleamine 2,3-dioxygenase 10101
Gamma-aminobutyric acid receptor subunit alpha-61001
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Alpha-synuclein0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
GABA theta subunit1001
Nuclear receptor ROR-beta0101
Gamma-aminobutyric acid receptor subunit epsilon1001
lethal factor (plasmid)1001
Rap guanine nucleotide exchange factor 31001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
pyruvate kinase PKM isoform a1001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Solute carrier family 22 member 60001
Albumin0011
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
UDP-glucuronosyltransferase 2B70001
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 70001
Reverse transcriptase/RNaseH 0126
Protease 0112
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]