Page last updated: 2024-09-28

Joint Deformities, Acquired

Deformities acquired after birth as the result of injury or disease. The joint deformity is often associated with rheumatoid arthritis and leprosy.

Synonyms(1)

Synonym
Joint Deformities, Acquired

Research

Studies (75)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (1.33)23.3326
1990's17 (22.67)12.5806
2000's23 (30.67)18.1394
2010's33 (44.00)28.8240
2020's1 (1.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
uric acid0low10
gentamicin0low10
ifosfamide0low10
sulfasalazine0low10
prednisolone0low10
penicillin g0low10
colchicine0low20
vancomycin0low10
titanium0low20
tricalcium phosphate0low10
calcium sulfate0low10
trolamine salicylate0medium303
cefazolin0low10
methotrexate0low10
cortisone0low10
cholecalciferol0low10
gadolinium dtpa0low10
vendex0low30
ro13-99040low10
interleukin-80low10
chondroitin sulfates0low10
allopurinol0low10

Protein Targets (428)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 83003
TDP1 protein5005
AR protein8008
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)3003
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha9009
IDH13003
euchromatic histone-lysine N-methyltransferase 25005
Bloom syndrome protein isoform 12002
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 24004
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin6006
survival motor neuron protein isoform d5005
lamin isoform A-delta106006
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40608
Polyphenol oxidase 20203
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump0909
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p535005
Glutamate receptor 24004
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0202
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0315
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 433003
Canalicular multispecific organic anion transporter 10505
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase4004
thioredoxin reductase5005
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma6006
Smad32002
apical membrane antigen 1, AMA11001
cytochrome P450 2D61001
vitamin D3 receptor isoform VDRA4004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Solute carrier family 22 member 60303
Solute carrier family 15 member 10202
Solute carrier family 22 member 60204
Solute carrier family 22 member 80405
Solute carrier family 22 member 110102
Solute carrier family 22 member 80203
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Ferritin light chain3003
Chain A, Cruzipain1001
15-lipoxygenase, partial2002
USP1 protein, partial4004
Microtubule-associated protein tau3003
aldehyde dehydrogenase 1 family, member A16006
retinoid X nuclear receptor alpha8008
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
thyroid hormone receptor beta isoform a2002
nuclear receptor ROR-gamma isoform 11001
DNA polymerase kappa isoform 13003
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Vitamin D3 receptor0114
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Glycine receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Vitamin D3 receptor0011
Nuclear receptor ROR-gamma2002
10 kDa heat shock protein, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
GABA theta subunit3003
Gamma-aminobutyric acid receptor subunit epsilon3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase2002
endonuclease IV2002
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit2002
ATAD5 protein, partial3003
Fumarate hydratase1001
PPM1D protein1001
GLI family zinc finger 34004
Thrombopoietin1001
nuclear receptor subfamily 1, group I, member 33003
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 14004
polyprotein1001
67.9K protein2002
glucocerebrosidase1001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 22002
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor2002
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 23003
atrial natriuretic peptide receptor 2 precursor1001
flap endonuclease 13003
steroidogenic factor 10101
peripheral myelin protein 222002
muscleblind-like protein 1 isoform 12002
caspase-1 isoform alpha precursor2002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 30101
Interferon beta3003
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10113
Cytochrome P450 3A40101
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10101
Histamine H2 receptor2002
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase2002
dopamine D1 receptor2002
GLS protein1001
regulator of G-protein signaling 41001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
heat shock protein beta-11001
M-phase phosphoprotein 82002
Glucocorticoid receptor04110
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10101
GALC protein1001
EWS/FLI fusion protein2002
Serum paraoxonase/arylesterase 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase2002
acid sphingomyelinase1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
Histone H2A.x2002
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
histone acetyltransferase KAT2A isoform 12002
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0202
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20415
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0303
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein1001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30203
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0202
Glutamine synthetase0011
Androgen receptor0303
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10404
Albumin0112
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Glutathione S-transferase0101
acetylcholinesterase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
G1001
thyroid stimulating hormone receptor1001
Replicase polyprotein 1ab0011
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Solute carrier organic anion transporter family member 2B1 0202
Tumor necrosis factor0011
HLA class I histocompatibility antigen, B alpha chain 1001
Interstitial collagenase0101
Fibroblast growth factor 10011
Thromboxane-A synthase 0101
Mitogen-activated protein kinase 10101
Caspase-10101
Flavin reductase (NADPH)0011
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium/bile acid cotransporter0101
Inositol hexakisphosphate kinase 11001
Cystine/glutamate transporter0101
Solute carrier organic anion transporter family member 1B10202
cytochrome P450 2C9, partial1001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Alpha-2A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent serotonin transporter0101
Alpha-1A adrenergic receptor0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]