Inversion of Uterus

A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM HEMORRHAGE.

Synonyms(2)

Synonym
Uterine Inversion
Inversion of Uterus

Research Excerpts

Overview

Excerpt	Reference
"Puerperal uterine inversion is a severe but rare obstetric complication of yet unknown origin."	( van Roosmalen, J; van Stralen, G; Witteveen, T; Zwart, J, 2013)
"Although uterine inversion is a potentially life-threatening complication of childbirth, there are only six case reports of cardiac arrest due to acute inversion to date."	( Datta, MR; Nag, DS; Panigrahi, B; Samaddar, DP, 2015)
"Uterine inversion is a life-threatening medical emergency, which can result in fatal shock and sudden unexpected death during and after delivery."	( Baraw, R; Barwa, J; Pradhan, M, 2016)
"Uterine inversion is a rare but known complication following parturition and may prove fatal due to neurogenic shock or postpartum hemorrhage if not corrected immediately."	( Bansal, R; Garg, P, 2020)

Research

Studies (23)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (8.70)	23.3326
1990's	3 (13.04)	12.5806
2000's	9 (39.13)	18.1394
2010's	8 (34.78)	28.8240
2020's	1 (4.35)	9.53

Drug	Relationship Strength	Studies
dalteparin	low	1
nitroglycerin	low	3
estrone	low	1
atropine	low	1
oxytocin	low	6
ergonovine	low	3
dactinomycin	low	1
syntometrine	low	3
warfarin	low	1

Protein Targets (316)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GLI family zinc finger 3	5	0	0	5
AR protein	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoid X nuclear receptor alpha	4	0	0	4
pregnane X nuclear receptor	5	0	0	5
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
5-hydroxytryptamine receptor 4	0	8	0	8
Bile salt export pump	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	8	0	8
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	2
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	2	0	0	2
Chain A, Cruzipain	1	0	0	1
interleukin 8	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
USP1 protein, partial	3	0	0	3
TDP1 protein	5	0	0	5
Microtubule-associated protein tau	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	6	0	0	6
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
caspase-3	2	0	0	2
RAD51	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	2	0	0	2
Caspase-7	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	3	0	0	3
huntingtin isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Interferon beta	4	0	0	4
Cellular tumor antigen p53	4	0	0	4
ATP-dependent translocase ABCB1	0	3	1	5
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Glutamate receptor 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	1	0	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Growth factor receptor-bound protein 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
GABA theta subunit	3	0	0	3
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
ATP-dependent translocase ABCB1	0	1	0	1
Alpha-2A adrenergic receptor	0	6	0	6
D(2) dopamine receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 1A	0	6	0	6
ATP-dependent translocase ABCB1	0	1	0	1
D(1A) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 1B	0	6	0	6
D(3) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2B	0	8	1	9
5-hydroxytryptamine receptor 6	0	6	0	6
endonuclease IV	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
GALC protein	1	0	0	1
nonstructural protein 1	1	0	0	1
G	1	0	0	1
arylsulfatase A	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
chromobox protein homolog 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Estrogen receptor	0	4	2	8
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Steryl-sulfatase	0	1	0	1
Aromatase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Androgen receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	4
Mu-type opioid receptor	0	0	1	1
Alpha-synuclein	1	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Cytochrome P450 1B1	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Estrogen receptor beta	0	3	2	6
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
acetylcholinesterase	2	0	0	2
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	1	0	0	1
DNA polymerase III, partial	2	0	0	2
regulator of G-protein signaling 4	2	0	0	2
cytochrome P450 2D6	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Cytochrome P450 2D6	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Chain A, CES1 protein	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	2	0	0	2
SMAD family member 3	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
interferon gamma precursor	0	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
geminin	1	0	0	1
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	1	0	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
EWS/FLI fusion protein	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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