Page last updated: 2024-09-27

Inversion of Uterus

A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM HEMORRHAGE.

Synonyms(2)

Synonym
Uterine Inversion
Inversion of Uterus

Research Excerpts

Overview

ExcerptReference
"Puerperal uterine inversion is a severe but rare obstetric complication of yet unknown origin."( van Roosmalen, J; van Stralen, G; Witteveen, T; Zwart, J, 2013)
"Although uterine inversion is a potentially life-threatening complication of childbirth, there are only six case reports of cardiac arrest due to acute inversion to date."( Datta, MR; Nag, DS; Panigrahi, B; Samaddar, DP, 2015)
"Uterine inversion is a life-threatening medical emergency, which can result in fatal shock and sudden unexpected death during and after delivery."( Baraw, R; Barwa, J; Pradhan, M, 2016)
"Uterine inversion is a rare but known complication following parturition and may prove fatal due to neurogenic shock or postpartum hemorrhage if not corrected immediately."( Bansal, R; Garg, P, 2020)

Research

Studies (23)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (8.70)23.3326
1990's3 (13.04)12.5806
2000's9 (39.13)18.1394
2010's8 (34.78)28.8240
2020's1 (4.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dalteparin0low10
nitroglycerin0low30
estrone0low10
atropine0low10
oxytocin0low60
ergonovine0low30
dactinomycin0low10
syntometrine0low30
warfarin0low10

Protein Targets (316)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, 2-oxoglutarate Oxygenase2002
GLI family zinc finger 35005
AR protein6006
nuclear receptor subfamily 1, group I, member 35005
glucocorticoid receptor [Homo sapiens]7007
retinoid X nuclear receptor alpha4004
pregnane X nuclear receptor5005
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
5-hydroxytryptamine receptor 40808
Bile salt export pump0404
Muscarinic acetylcholine receptor M20418
Muscarinic acetylcholine receptor M40417
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50417
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10418
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30417
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0808
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor1002
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0102
Muscarinic acetylcholine receptor0112
Canalicular multispecific organic anion transporter 10202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
interleukin 81001
15-lipoxygenase, partial1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
USP1 protein, partial3003
TDP1 protein5005
Microtubule-associated protein tau3003
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen receptor 2 (ER beta)3003
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 14004
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor2002
estrogen nuclear receptor alpha6006
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-32002
RAD510101
euchromatic histone-lysine N-methyltransferase 23003
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
Caspase-72002
Bloom syndrome protein isoform 12002
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform a2002
caspase-32002
thyroid hormone receptor beta isoform 23003
huntingtin isoform 21001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 12002
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
caspase-1 isoform alpha precursor1001
Gamma-aminobutyric acid receptor subunit pi3003
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta4004
Cellular tumor antigen p534004
ATP-dependent translocase ABCB10315
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 22002
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Nuclear receptor ROR-gamma1001
Caspase-71001
Spike glycoprotein1012
Gamma-aminobutyric acid receptor subunit alpha-13003
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
GABA theta subunit3003
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Gamma-aminobutyric acid receptor subunit epsilon3003
ATP-dependent translocase ABCB10101
Alpha-2A adrenergic receptor0606
D(2) dopamine receptor0606
Alpha-2B adrenergic receptor0606
5-hydroxytryptamine receptor 1A0606
ATP-dependent translocase ABCB10101
D(1A) dopamine receptor0606
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 1B0606
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 2B0819
5-hydroxytryptamine receptor 60606
endonuclease IV1001
ATAD5 protein, partial1001
NFKB1 protein, partial1001
GALC protein1001
nonstructural protein 11001
G1001
arylsulfatase A3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 11001
chromobox protein homolog 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
lamin isoform A-delta102002
Rap guanine nucleotide exchange factor 31001
HLA class I histocompatibility antigen, B alpha chain 1001
Estrogen receptor0428
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Steryl-sulfatase0101
Aromatase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
17-beta-hydroxysteroid dehydrogenase type 10203
Androgen receptor0404
Sodium-dependent serotonin transporter0404
Mu-type opioid receptor0011
Alpha-synuclein1102
Solute carrier organic anion transporter family member 1A10101
Mu-type opioid receptor0011
Inositol monophosphatase 11001
TAR DNA-binding protein 431001
Cytochrome P450 1B10101
Inositol hexakisphosphate kinase 11001
Estrogen receptor beta0326
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
cytochrome P450 2C9, partial1001
acetylcholinesterase2002
dopamine D1 receptor1001
thioredoxin reductase1001
phosphopantetheinyl transferase2002
GLS protein1001
DNA polymerase III, partial2002
regulator of G-protein signaling 42002
cytochrome P450 2D61001
D(1A) dopamine receptor2002
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
tumor susceptibility gene 101 protein1001
M-phase phosphoprotein 82002
Cytochrome P450 2D60101
Multidrug and toxin extrusion protein 10101
ATP-dependent phosphofructokinase1001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Potassium voltage-gated channel subfamily H member 20303
Chain A, CES1 protein0101
Chain A, Beta-lactamase2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
SMAD family member 21001
Fumarate hydratase1001
PPM1D protein2002
SMAD family member 31001
apical membrane antigen 1, AMA11001
polyprotein1001
67.9K protein1001
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B1001
IDH11001
thyroid stimulating hormone receptor1001
thyrotropin-releasing hormone receptor1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
transcriptional regulator ERG isoform 31001
heat shock protein beta-11001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
geminin1001
streptokinase A precursor0011
lethal factor (plasmid)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
Serine/threonine-protein kinase D30101
Epidermal growth factor receptor0101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-31001
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Cytochrome P450 2B60101
Substance-K receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Substance-P receptor0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
D(1A) dopamine receptor1001
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
EWS/FLI fusion protein1001
Albumin0011
Albumin0011
Cytochrome P450 2C9 0101
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]