Page last updated: 2024-09-27

Intraocular Lymphoma

A form of malignant cancer which occurs within the eyeball.

Synonyms(1)

Synonym
Intraocular Lymphoma

Research Excerpts

Overview

ExcerptReference
"Primary intraocular lymphoma is a rare variant of primary CNS lymphoma for which the optimum treatment strategy remains unknown."( Cheah, CY; Chihara, D; Dabaja, BS; Fowler, NH; Gombos, DS; Milgrom, S; Pinnix, CC, 2016)

Research

Studies (43)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's24 (55.81)28.8240
2020's19 (44.19)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
ifosfamide0low10
2-propanol0low10
procarbazine0medium21
thalidomide0low10
thiotepa0medium11
prednisone0low10
leucine0low10
cytarabine0medium22
etoposide0low10
propiconazole0low10
bendamustine hydrochloride0low10
methotrexate0medium294
pomalidomide0low10
proline0low10
lenalidomide0medium31
melphalan0low10
indocyanine green0low10
chitosan0low10
eye0low20

Protein Targets (298)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma8008
GLI family zinc finger 38008
AR protein110011
aldehyde dehydrogenase 1 family, member A16006
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha8008
estrogen nuclear receptor alpha100010
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x6006
thyroid hormone receptor beta isoform a4004
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 17007
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit6006
Glutamate receptor 26006
estrogen-related nuclear receptor alpha9009
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
endonuclease IV1001
glp-1 receptor, partial4004
thioredoxin reductase4004
phosphopantetheinyl transferase4004
USP1 protein, partial4004
TDP1 protein8008
nuclear receptor subfamily 1, group I, member 38008
cytochrome P450 family 3 subfamily A polypeptide 45005
EWS/FLI fusion protein9009
glucocorticoid receptor [Homo sapiens]5005
G3003
67.9K protein3003
LMP1 [Human herpesvirus 4]0003
euchromatic histone-lysine N-methyltransferase 25005
chromobox protein homolog 16006
nuclear factor erythroid 2-related factor 2 isoform 24004
thyroid hormone receptor beta isoform 28008
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase iota isoform a (long)5005
transactivating tegument protein VP16 [Human herpesvirus 1]0303
geminin6006
peripheral myelin protein 223003
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40708
Bile salt export pump0808
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Thymidine kinase, cytosolic0101
Cellular tumor antigen p538008
Thymidine kinase0101
Thymidylate synthase0203
Cytochrome P450 3A40303
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10809
Ataxin-25005
Thymidine kinase0101
Deoxynucleoside kinase0101
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase2002
SMAD family member 22002
SMAD family member 32002
caspase 7, apoptosis-related cysteine protease2002
progesterone receptor6006
pregnane X nuclear receptor7007
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
caspase-32002
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10203
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0102
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
ATPase family AAA domain-containing protein 54004
Solute carrier organic anion transporter family member 1B30203
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, Beta-lactamase2002
GALC protein2002
acetylcholinesterase3003
estrogen receptor 2 (ER beta)5005
cytochrome P450 2D64004
cellular tumor antigen p53 isoform a2002
Integrin beta-32002
Integrin alpha-IIb2002
Cereblon isoform 40404
Bromodomain-containing protein 40101
Tyrosine-protein kinase ABL10013
Breakpoint cluster region protein0002
DNA-binding protein Ikaros0027
DNA damage-binding protein 10325
Protein cereblon06314
Zinc finger protein Aiolos0022
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10203
Phospholipase A-2-activating protein0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
15-lipoxygenase, partial3003
Fumarate hydratase1001
GLS protein2002
thioredoxin glutathione reductase2002
Smad31001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
farnesoid X nuclear receptor5005
polyprotein1001
glucocerebrosidase1001
aryl hydrocarbon receptor2002
Caspase-71001
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
importin subunit beta-1 isoform 12002
snurportin-12002
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Nuclear receptor ROR-gamma2002
Spike glycoprotein3003
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
TAR DNA-binding protein 433003
Large neutral amino acids transporter small subunit 1 0101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
ATAD5 protein, partial1001
Microtubule-associated protein tau1001
Thymidylate synthase 0101
alpha-galactosidase1001
IDH11001
Thymidylate synthase 0101
Bloom syndrome protein isoform 12002
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA4004
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
flap endonuclease 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Carbonic anhydrase 20011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Programmed cell death protein 10101
E3 ubiquitin-protein ligase ZFP910001
Programmed cell death 1 ligand 10101
pregnane X receptor2002
nuclear receptor ROR-gamma isoform 12002
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
cytochrome P450 2C19 precursor1001
lethal factor (plasmid)1001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
arylsulfatase A1001
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Luciferase1001
regulator of G-protein signaling 41001
hemoglobin subunit beta1001
serine/threonine-protein kinase PLK11001
Cytochrome P450 2B10101
Cytochrome P450 2B60101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]