Page last updated: 2024-09-28

Injuries, Lightning

Accidental injuries caused by brief high-voltage electrical discharges during thunderstorms. Cardiopulmonary arrest, coma and other neurologic symptoms, myocardial necrosis, and dermal burns are common. Prompt treatment of the acute sequelae, including cardiopulmonary resuscitation, is indicated for survival.

Synonyms(3)

Synonym
Lightning Injuries
Lightning Stroke
Injuries, Lightning

Research

Studies (30)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (6.67)23.3326
1990's6 (20.00)12.5806
2000's13 (43.33)18.1394
2010's6 (20.00)28.8240
2020's3 (10.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
salicylic acid0low10
amiodarone0low10
aspirin0low10
clonidine0low10
furosemide0low10
gabapentin0low10
khellin0low20
methylprednisolone0low10
isosorbide dinitrate0low10
silver0low30
thallium chloride0low10
isosorbide-5-mononitrate0low10
4-methoxyamphetamine0low30
simendan0low10
cocaine0low10
thallium0low10
technetium tc 99m sestamibi0low10
ro13-99040low10
exudates0low10
eye0low10

Protein Targets (472)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0314
5-hydroxytryptamine receptor 2A0314
5-hydroxytryptamine receptor 1A0527
5-hydroxytryptamine receptor 1B0415
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B0314
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter0415
Sodium-dependent serotonin transporter0304
5-hydroxytryptamine receptor 7 0112
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 4 0112
5-hydroxytryptamine receptor 3B0112
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
acetylcholinesterase3003
phosphopantetheinyl transferase1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma2002
SMAD family member 21001
ATAD5 protein, partial2002
Fumarate hydratase1001
USP1 protein, partial3003
NFKB1 protein, partial1001
PPM1D protein2002
SMAD family member 31001
TDP1 protein2002
Thrombopoietin1001
AR protein6006
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor2002
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha5005
G3003
cytochrome P450 2D64004
polyprotein1001
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma1001
caspase-31001
euchromatic histone-lysine N-methyltransferase 24004
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor2002
D(1A) dopamine receptor2002
chromobox protein homolog 11001
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-11001
huntingtin isoform 21001
mitogen-activated protein kinase 12002
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 11001
geminin5005
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)2002
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi2215
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier organic anion transporter family member 1A40101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Lysine-specific demethylase PHF20101
Bile salt export pump0707
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p532002
Integrin beta-31102
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10417
Integrin alpha-IIb1102
Beta-1 adrenergic receptor0415
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0415
Adenosine receptor A30202
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10202
Beta-3 adrenergic receptor0213
D(2) dopamine receptor0202
Androgen receptor0404
Gamma-aminobutyric acid receptor subunit beta-12215
Alpha-1B adrenergic receptor0303
Lethal factor0101
Alpha-2B adrenergic receptor0415
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta2215
Gamma-aminobutyric acid receptor subunit gamma-22226
Gamma-aminobutyric acid receptor subunit alpha-52215
Gamma-aminobutyric acid receptor subunit alpha-32215
Muscarinic acetylcholine receptor M30202
ATP-dependent translocase ABCB10101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-12215
Gamma-aminobutyric acid receptor subunit alpha-22215
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0202
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-42215
Gamma-aminobutyric acid receptor subunit gamma-32215
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-62215
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0314
Histamine H2 receptor2002
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein3003
Gamma-aminobutyric acid receptor subunit alpha-12327
Gamma-aminobutyric acid receptor subunit beta-32215
Gamma-aminobutyric acid receptor subunit beta-22226
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit2215
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10505
Sodium channel protein type 2 subunit alpha0101
Ataxin-22002
Sigma non-opioid intracellular receptor 10415
Gamma-aminobutyric acid receptor subunit epsilon2215
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial3003
ATP-dependent phosphofructokinase3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase3003
GLS protein1001
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocerebrosidase1001
Rac1 protein0011
IDH12002
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Carbonic anhydrase 10506
Carbonic anhydrase 20506
Fatty acid-binding protein, liver0101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0112
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
regulator of G-protein signaling 43003
Beta-1 adrenergic receptor 0022
arylsulfatase A2002
Alpha-1B adrenergic receptor 0011
cytochrome P450 2C19 precursor2002
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0203
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30202
5-hydroxytryptamine receptor 1A0101
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0213
D0202
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0303
Amine oxidase [flavin-containing] A0101
Alpha-2C adrenergic receptor0303
Alpha-2A adrenergic receptor0303
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0213
D(1B) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Adenosine receptor A2b0011
Alpha-2B adrenergic receptor0001
D(4) dopamine receptor0101
Delta-type opioid receptor0101
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0202
Mu-type opioid receptor0101
Inositol monophosphatase 11001
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10202
Nischarin0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Liver carboxylesterase 10001
Sodium-dependent dopamine transporter0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Glutamate receptor ionotropic, NMDA 1 0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit epsilon0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60213
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Glutamate receptor ionotropic, NMDA 3B0101
Gamma-aminobutyric acid receptor subunit gamma-30202
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0202
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor1001
Carbonic anhydrase 120203
Bile salt export pump0202
Albumin0202
Carbonic anhydrase 30202
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0303
Carbonic anhydrase 40203
Carbonic anhydrase 60203
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0203
Carbonic anhydrase 70203
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20202
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90203
Carbonic anhydrase 130203
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140203
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0203
thioredoxin glutathione reductase1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A1001
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, Beta-lactamase1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
glp-1 receptor, partial1001
GALC protein1001
GLI family zinc finger 32002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 3A40101
Cytochrome P450 2D60202
Cytochrome P450 2C190101
Cytochrome P450 1B10101
nonstructural protein 11001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 21001
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
ATPase family AAA domain-containing protein 51001
Nuclear receptor subfamily 1 group I member 20011
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0112
Beta-1 adrenergic receptor0101
Beta-2 adrenergic receptor0011
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Solute carrier family 22 member 80101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
chemdatabank.com