Immunoblastic Large-Cell Lymphoma

Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.

Synonym
Sarcoma, Immunoblastic
Immunoblastoma
Lymphoma, Immunoblastic, Large Cell
Lymphoma, Large-Cell, Immunoblastic
Immunoblastic Lymphosarcoma, Diffuse
Large-Cell Immunoblastic Lymphoma
Lymphoma, Large Cell, Immunoblastic
Immunoblastic Large-Cell Lymphoma
Lymphoma, Immunoblastic, Large-Cell

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.33)	23.3326
1990's	36 (48.00)	12.5806
2000's	20 (26.67)	18.1394
2010's	18 (24.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
alpha-hydroxyglutarate	low	1	0
citric acid, anhydrous	low	1	0
cytosine	low	1	0
formaldehyde	low	1	0
azathioprine	low	1	0
busulfan	medium	3	1
carmustine	medium	2	1
furosemide	low	1	0
ifosfamide	medium	5	5
mitoxantrone	medium	2	2
procarbazine	medium	2	1
vorinostat	medium	1	1
thalidomide	medium	2	1
thiotepa	medium	2	1
prednisolone	medium	6	2
prednisone	medium	37	11
desoxycorticosterone	low	1	0
cytarabine	medium	10	5
methylprednisolone	medium	2	1
pyrazines	low	3	0
podophyllotoxin	medium	1	1
deoxycytidine	low	1	0
methylprednisolone hemisuccinate	medium	2	2
vidarabine	low	2	0
barium sulfate	low	1	0
zidovudine	low	1	0
etoposide	medium	15	8
vindesine	medium	2	1
idarubicin	low	1	0
cidofovir anhydrous	low	1	0
gemcitabine	low	1	0
fluorodeoxyglucose f18	low	2	0
imipenem, anhydrous	low	1	0
methotrexate	medium	17	8
organophosphonates	low	1	0
lenalidomide	medium	2	1
bortezomib	low	3	0
ritonavir	low	1	0
melphalan	medium	1	1
bromochloroacetic acid	low	1	0
fludarabine	low	2	0
quinine	low	1	0
gadolinium dtpa	low	1	0
etoposide phosphate	low	1	0
mesna	medium	3	2
technetium tc 99m sulfur colloid	low	1	0
cyclosporine	low	2	0
acyclovir	low	1	0
levoleucovorin	medium	5	2
folic acid	low	1	0

Protein Targets (753)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	7	0	0	7
Thymidine kinase	0	2	0	2
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	7	0	0	7
GLS protein	6	0	0	6
TDP1 protein	23	0	0	23
Smad3	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	21	0	0	21
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
activating transcription factor 6	7	0	0	7
Histone H2A.x	8	0	0	8
Bloom syndrome protein isoform 1	7	0	0	7
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lamin isoform A-delta10	12	0	0	12
Solute carrier family 22 member 1	0	4	0	5
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	24
Solute carrier family 22 member 6	0	1	0	4
Bile salt export pump	0	5	0	5
Bile salt export pump	0	26	0	26
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	6
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	7	0	7
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	5
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	3
Canalicular multispecific organic anion transporter 1	0	23	0	24
Thymidine kinase	0	2	0	2
Methylcytosine dioxygenase TET2	0	1	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
interleukin 8	1	0	0	1
acetylcholinesterase	4	0	0	4
RAR-related orphan receptor gamma	15	0	0	15
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	6	0	0	6
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	21	0	0	21
Microtubule-associated protein tau	6	0	0	6
AR protein	20	0	0	20
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
glucocorticoid receptor [Homo sapiens]	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
retinoid X nuclear receptor alpha	16	0	0	16
estrogen-related nuclear receptor alpha	21	0	0	21
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	23	0	0	23
G	7	0	0	7
polyprotein	6	0	0	6
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	11	0	0	11
IDH1	8	0	0	8
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
thyroid stimulating hormone receptor	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
peripheral myelin protein 22 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	18	0	0	18
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
DNA polymerase iota isoform a (long)	10	0	0	10
geminin	18	0	0	18
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	8	0	0	8
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	17	0	0	17
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Nuclear receptor ROR-gamma	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
GABA theta subunit	5	0	0	5
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	13	0	0	13
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	7	0	0	7
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
PPM1D protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	5	0	0	5
estrogen receptor 2 (ER beta)	7	0	0	7
progesterone receptor	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
caspase-3	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	3	1	7
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	2	0	3
Prothrombin	0	1	0	2
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	1	4
Carbonic anhydrase 3	0	2	0	2
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	2	0	3
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	2	0	3
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	3	2	8
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	3	2	8
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Histone deacetylase 8	0	3	2	8
Histone deacetylase 6	0	3	2	8
Carbonic anhydrase 14	0	2	0	3
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
15-lipoxygenase, partial	6	0	0	6
apical membrane antigen 1, AMA1	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
lethal factor (plasmid)	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
endonuclease IV	3	0	0	3
cytochrome P450 2D6	7	0	0	7
thyroid hormone receptor beta isoform a	5	0	0	5
huntingtin isoform 2	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Glutathione reductase, mitochondrial	0	1	0	1
Alpha-synuclein	2	0	0	2
Glutathione reductase	0	1	0	1
ATP-dependent phosphofructokinase	8	0	0	8
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Thymidine kinase	0	0	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
glp-1 receptor, partial	5	0	0	5
USP1 protein, partial	9	0	0	9
67.9K protein	7	0	0	7
LMP1 [Human herpesvirus 4]	0	0	0	3
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Cytochrome P450 3A4	0	6	0	8
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	3
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
D(1A) dopamine receptor	2	0	0	2
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	1	3	7
GALC protein	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
TAR DNA-binding protein 43	3	1	0	4
Solute carrier family 22 member 2	0	3	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
Regulatory protein E2	0	0	2	2
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	6	0	8
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	2
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	9
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	2	0	2
Integrase	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	6	0	7
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Spike glycoprotein	6	0	1	7
Chain A, Beta-lactamase	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
acid sphingomyelinase	2	0	0	2
glucocerebrosidase	2	0	0	2
alpha-galactosidase	4	0	0	4
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	3	0	0	3
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
Albumin	0	2	2	6
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	5
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
DNA polymerase III, partial	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
nonstructural protein 1	2	0	0	2
NPYLR7B	0	0	1	1
Parkin	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
glucokinase regulatory protein	1	0	0	1
flap endonuclease 1	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Amyloid-beta precursor protein	2	1	0	3
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Single-stranded DNA cytosine deaminase	2	0	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	2	0	2
Tyrosine-protein kinase ABL1	0	1	1	3
Breakpoint cluster region protein	0	0	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Luciferase	4	0	0	4
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Glucocorticoid receptor	0	7	2	14
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	4	0	4
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
hypothetical protein, conserved	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
phospholipase A2, group III	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
interferon gamma precursor	0	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Vpr	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Solute carrier family 22 member 2	0	3	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
Epidermal growth factor receptor	0	2	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Cytochrome P450 2D6	0	5	0	5
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Casein kinase II subunit alpha'	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Histamine H2 receptor	1	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Tyrosine-protein kinase BTK	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
PAX8	0	0	0	2
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Prostaglandin G/H synthase 1	0	2	0	2
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Cytochrome P450 2C19	0	3	0	3
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Prostaglandin G/H synthase 2	0	1	0	1
Tubulin beta-3 chain	0	1	1	3
Tubulin beta-2A chain	0	1	1	3
Tubulin beta-8 chain	0	1	1	3
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	2	2
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Cruzipain	1	0	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Substance-K receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Protease	0	2	2	6
Plasmepsin V	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Protease	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Heat shock protein HSP 90-alpha	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	0	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Histone deacetylase 4	0	2	1	6
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
Histone deacetylase 7	0	2	2	7
HD2 type histone deacetylase HDA106	0	2	0	2
Polyamine deacetylase HDAC10	0	2	1	6
Histone deacetylase 11	0	2	1	6
Carboxypeptidase B2	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
REST corepressor 3	0	1	0	1
Histone deacetylase 9	0	2	1	6
Histone deacetylase 5	0	2	1	6
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Immunoblastic Large-Cell Lymphoma

Synonyms(9)

Research

Studies (75)

Protein Targets (753)

Immunoblastic Large-Cell Lymphoma

Synonyms(9)

Research

Studies (75)

Drugs Studied (60)

Protein Targets (753)