Page last updated: 2024-09-28

Histiocyte Syndrome, Sea Blue

A congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.

Synonyms(7)

Synonym
Sea-Blue Histiocyte Disease
Histiocyte Syndromes, Sea Blue
Histiocyte Syndrome, Sea Blue
Sea Blue Histiocytosis
Histiocytosis, Sea-Blue
Sea-Blue Histiocyte Syndrome
Sea-Blue Histiocytosis

Research

Studies (6)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (16.67)23.3326
1990's1 (16.67)12.5806
2000's4 (66.67)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low10
valproic acid0low10
phenobarbital0low10
acid phosphatase0low10

Protein Targets (51)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein1001
geminin1001
Bile salt export pump0202
Sodium channel protein type 1 subunit alpha0101
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Luciferase1001
pregnane X receptor1001
nuclear receptor subfamily 1, group I, member 31001
glucocorticoid receptor [Homo sapiens]1001
retinoic acid nuclear receptor alpha variant 11001
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor1001
estrogen nuclear receptor alpha1001
peroxisome proliferator activated receptor gamma1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
thyroid hormone receptor beta isoform a1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear factor erythroid 2-related factor 2 isoform 11001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Cellular tumor antigen p531001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Nuclear receptor ROR-gamma1001
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]