High T4 Syndrome

Synonym
Low T3-High T4 Syndrome
Low T3 and Low T4 Syndrome
Sick Euthyroid Syndrome
High T4 Syndrome
Low T3 High T4 Syndrome
Low T3 Syndrome
Non-Thyroidal Illness Syndrome
Low T3-Low T4 Syndrome

Excerpt	Reference
"The sick euthyroid syndrome is a poorly understood hallmark of critical illness."	( de Zegher, F; Lauwers, P; Van den Berghe, G, 1994)
"The "sick euthyroid syndrome" is also seen in association with significant illnesses and consists of decreased levels of circulating triiodothyronine (T3)."	( Chapital, AD; Hendrick, SR; Lloyd, L; Pieper, D, 2001)
"Sick euthyroid syndrome is defined as the decrease of serum free triiodothyronine with normal free L-thyroxin and thyrotropin."	( Boudonas, G; Efthimiadis, A; Keskilidis, C; Lefkos, N; Psirropoulos, D; Tsapas, G; Vogas, V, 2002)
"Low T3 syndrome is frequently found in patients with HFrEF and is associated with a poor outcome."	( Fraczek-Jucha, M; Gackowski, A; Kabat, M; Nessler, J; Plens, K; Rychlak, R; Zbierska-Rubinkiewicz, K, 2019)
"Low T3 syndrome is frequent in patients admitted to intensive care units for critical illness and pneumonia."	( Amodeo, R; Anibaldi, P; Ciliberto, G; D'Ascanio, M; De Dominicis, C; de Latouliere, L; De Vitis, C; Di Napoli, A; Fanciulli, M; Giovagnoli, S; Laghi, A; Mancini, R; Napoli, C; Petrucca, A; Piaggio, G; Ricci, A; Sacconi, A; Salerno, G; Salvati, V; Santino, I; Sciacchitano, S; Simmaco, M; Tafuri, A, 2021)
"Sick euthyroid syndrome is abnormal findings of thyroid function tests that occur among patients with non thyroid illness with reduced level of hormones like T3 (Triiodothyronine) among acute illness of poisoning and can be detected in blood within 2 hours after acute illness."	( Yadav, I, 2022)

Excerpt	Reference
"The so-called "low T3 syndrome" has frequently been reported in patients with cirrhosis."	( Bellanova, B; Bernardi, M; De Palma, R; Gasbarrini, G; Pesa, O; Tame, MR; Trevisani, F; Vecchi, F, 1989)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	21 (6.65)	23.3326
1990's	90 (28.48)	12.5806
2000's	88 (27.85)	18.1394
2010's	76 (24.05)	28.8240
2020's	41 (12.97)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
lactic acid	low	1	0
iodine	medium	6	2
thiamine	low	1	0
phenytoin	low	1	0
amiodarone	low	5	0
atenolol	medium	1	1
carbamazepine	low	1	0
diazepam	medium	1	1
methamidophos	low	1	0
methylphenidate	medium	1	1
metoclopramide	low	1	0
aminosalicylic acid	low	1	0
propranolol	low	2	0
salicylsalicylic acid	low	1	0
prednisolone	low	1	0
3,3',5-triiodothyroacetic acid	low	1	0
thyroxine	medium	174	20
dextroamphetamine	medium	1	1
aldosterone	low	2	0
prednisone	low	2	0
triiodothyronine	medium	192	19
physostigmine	low	1	0
methylprednisolone	low	1	0
betamethasone	low	1	0
malondialdehyde	low	1	0
lithium carbonate	low	1	0
acetylcysteine	medium	6	1
d-alpha tocopherol	medium	1	1
bromophos	low	1	0
betamethasone valerate	low	1	0
dithiothreitol	low	1	0
technetium	low	1	0
sodium selenite	low	1	0
4-methoxyamphetamine	low	1	0
transferrin	low	1	0
dobutamine	medium	1	1
propiconazole	low	1	0
fomesafen	low	1	0
pyrrolidine dithiocarbamate	low	1	0
tetraiodothyroacetic acid	low	1	0
clarithromycin	low	1	0
pyridinoline	low	1	0
deoxypyridinoline	low	1	0
angiotensin ii	low	3	0
hydroxydione	low	1	0
n-acetylneuraminic acid	low	1	0
tretinoin	low	1	0
oleic acid	low	1	0
melphalan	medium	2	1
sodium bicarbonate	medium	2	1
arginine vasopressin	low	1	0
propylthiouracil	low	1	0
methimazole	low	1	0
ethionamide	low	1	0
bilirubin	medium	1	1
dinoprost	low	1	0
calcitriol	medium	1	1
8-epi-prostaglandin f2alpha	low	1	0
thyronines	low	3	0
selenium	medium	11	1
losartan potassium	low	1	0
atrial natriuretic factor	low	4	0
glucagon	low	1	0
technetium tc 99m sestamibi	medium	1	1
sodium pertechnetate tc 99m	low	1	0
triiodothyronine, reverse	medium	23	7
interleukin-8	low	1	0
vasoactive intestinal peptide	low	1	0
natriuretic peptide, brain	low	3	0
salicylates	low	2	0
calca protein, human	low	1	0
transforming growth factor beta	low	2	0
thymic factor, circulating	low	1	0
rome	low	1	0
humulin s	low	1	0
muramidase	low	1	0
leptin	low	6	0

Protein Targets (675)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
SMAD family member 2	4	0	0	4
USP1 protein, partial	12	0	0	12
SMAD family member 3	4	0	0	4
AR protein	29	0	0	29
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
estrogen receptor 2 (ER beta)	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
progesterone receptor	18	0	0	18
glucocorticoid receptor [Homo sapiens]	22	0	0	22
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	27	0	0	27
farnesoid X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	35	0	0	35
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
cytochrome P450 2C9 precursor	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	6	0	0	6
thyroid hormone receptor beta isoform 2	15	0	0	15
heat shock protein beta-1	8	0	0	8
DNA polymerase beta	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
geminin	18	0	0	18
survival motor neuron protein isoform d	7	0	0	7
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lamin isoform A-delta10	17	0	0	17
Cellular tumor antigen p53	17	0	0	17
Androgen receptor	0	5	0	5
Thyroid hormone receptor alpha	0	4	4	8
Thyroid hormone receptor beta	0	4	4	8
Proliferating cell nuclear antigen	0	3	0	3
Thyroid hormone receptor beta	0	3	0	3
Retinoic acid receptor RXR-alpha	0	2	9	11
Peroxisome proliferator-activated receptor gamma	0	0	8	8
Histamine H2 receptor	4	0	0	4
Sodium/bile acid cotransporter	0	2	0	2
Solute carrier organic anion transporter family member 1C1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	2	4
5-hydroxytryptamine receptor 2A	0	2	2	4
5-hydroxytryptamine receptor 1A	0	11	5	17
5-hydroxytryptamine receptor 1B	0	6	2	8
5-hydroxytryptamine receptor 1D	0	2	2	4
5-hydroxytryptamine receptor 1F	0	2	2	4
5-hydroxytryptamine receptor 2B	0	2	2	4
5-hydroxytryptamine receptor 6	0	0	2	2
Sodium-dependent serotonin transporter	0	12	2	14
Sodium-dependent serotonin transporter	0	1	1	2
5-hydroxytryptamine receptor 7	0	0	2	2
5-hydroxytryptamine receptor 5A	0	0	2	2
5-hydroxytryptamine receptor 5B	0	0	2	2
5-hydroxytryptamine receptor 3A	0	2	2	4
5-hydroxytryptamine receptor 4	0	1	2	4
5-hydroxytryptamine receptor 3B	0	2	2	4
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
acetylcholinesterase	10	0	0	10
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	9	0	0	9
RAR-related orphan receptor gamma	17	0	0	17
NFKB1 protein, partial	2	0	0	2
Microtubule-associated protein tau	8	0	0	8
Thrombopoietin	2	0	0	2
regulator of G-protein signaling 4	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
arylsulfatase A	5	0	0	5
Bloom syndrome protein isoform 1	5	0	0	5
D(1A) dopamine receptor	6	0	0	6
thyroid hormone receptor beta isoform a	11	0	0	11
flap endonuclease 1	3	0	0	3
peripheral myelin protein 22	11	0	0	11
muscarinic acetylcholine receptor M1	4	0	0	4
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	14	0	0	14
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	3	3	6
Androgen receptor	0	6	0	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
thioredoxin glutathione reductase	5	0	0	5
Smad3	4	0	0	4
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	3	0	0	3
PPM1D protein	3	0	0	3
TDP1 protein	17	0	0	17
caspase 7, apoptosis-related cysteine protease	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
EWS/FLI fusion protein	7	0	0	7
pregnane X nuclear receptor	23	0	0	23
G	9	0	0	9
cytochrome P450 2D6	7	0	0	7
polyprotein	3	0	0	3
caspase-3	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
Histone H2A.x	8	0	0	8
cytochrome P450 2D6 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
chromobox protein homolog 1	11	0	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
huntingtin isoform 2	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	7	0	0	7
cytochrome P450 3A4 isoform 1	3	0	0	3
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	4	4	11
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	18
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Lysine-specific demethylase PHF2	0	1	0	1
Bile salt export pump	0	25	0	25
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	2	1	0	3
Tyrosine-protein kinase Fyn	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	5	0	5
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	7	2	17
Integrin alpha-IIb	2	0	0	2
Beta-1 adrenergic receptor	0	8	3	11
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	7	2	10
Adenosine receptor A3	0	5	1	6
Cytochrome P450 2C8	0	3	0	3
Muscarinic acetylcholine receptor M1	0	3	1	4
Beta-3 adrenergic receptor	0	4	3	7
D(2) dopamine receptor	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-1	3	4	4	11
Alpha-1B adrenergic receptor	0	7	1	8
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	6
Gamma-aminobutyric acid receptor subunit delta	3	4	4	11
Gamma-aminobutyric acid receptor subunit gamma-2	3	4	4	11
Gamma-aminobutyric acid receptor subunit alpha-5	3	4	4	11
Gamma-aminobutyric acid receptor subunit alpha-3	3	4	4	11
Muscarinic acetylcholine receptor M3	0	3	1	4
ATP-dependent translocase ABCB1	0	2	0	3
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	3	1	4
D(4) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	3	4	4	11
Gamma-aminobutyric acid receptor subunit alpha-2	3	4	4	11
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	8	1	9
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	8	1	9
5-hydroxytryptamine receptor 2C	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-4	3	4	4	11
Gamma-aminobutyric acid receptor subunit gamma-3	3	4	4	11
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	4	4	11
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	3	1	4
D(3) dopamine receptor	0	8	0	8
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	5
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	3	1	4
5-hydroxytryptamine receptor 2B	0	10	1	11
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	7	1	8
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	4	1	5
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	3	4	4	11
Gamma-aminobutyric acid receptor subunit beta-3	3	4	4	11
Gamma-aminobutyric acid receptor subunit beta-2	3	4	4	11
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	8	1	9
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	4	0	4
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	3	4	4	11
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	9	0	0	9
Canalicular multispecific organic anion transporter 1	0	16	0	16
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	6	0	6
Gamma-aminobutyric acid receptor subunit epsilon	3	4	4	11
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	9	0	0	9
glucocerebrosidase	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Translocator protein	0	1	2	4
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	2	4
DNA polymerase iota isoform a (long)	3	0	0	3
Fatty acid-binding protein, liver	0	4	0	4
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	7	3	10
Alpha-1D adrenergic receptor	0	3	1	5
Alpha-1A adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	1	1	3
TAR DNA-binding protein 43	3	0	0	3
Beta-2 adrenergic receptor	0	1	2	4
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
GLI family zinc finger 3	20	0	0	20
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
IDH1	4	0	0	4
aryl hydrocarbon receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
galanin receptor type 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glutamate receptor 2	9	0	0	9
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, Cruzipain	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	3	0	5
Solute carrier organic anion transporter family member 1B1	0	5	0	8
Beta-1 adrenergic receptor	0	2	0	2
Luciferase	10	0	0	10
activating transcription factor 6	6	0	0	6
ATPase family AAA domain-containing protein 5	9	0	0	9
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, Ferritin light chain	3	0	0	3
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	1	3
Cytochrome P450 3A4	0	6	1	8
Cytochrome P450 2D6	0	5	1	6
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	6	1	8
Vitamin D3 receptor	0	1	1	3
Cytochrome P450 2C19	0	2	1	3
Kappa-type opioid receptor	0	1	1	2
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Vpr	1	0	0	1
Bile salt export pump	0	6	0	6
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2B6	0	0	1	1
Cytochrome P450 2J2	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
streptokinase A precursor	0	0	1	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Sodium-dependent dopamine transporter	0	1	1	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	2	0	2
glp-1 receptor, partial	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	3	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	6	0	8
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
thioredoxin reductase	9	0	0	9
GALC protein	1	0	0	1
GLS protein	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Carbonic anhydrase 12	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Polyphenol oxidase 2	0	3	0	5
Nuclear receptor ROR-gamma	5	1	1	7
histone deacetylase 9 isoform 3	1	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
nonstructural protein 1	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Myeloperoxidase	0	2	0	2
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	1	2
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	1	2
Acetylcholinesterase	0	2	0	3
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 7	0	3	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	2	0	2
Protein kinase C alpha type	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
endonuclease IV	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Acetylcholinesterase	0	2	0	3
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	3
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	2	1	4
Alpha-2C adrenergic receptor	0	1	2	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
interleukin 8	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Integrin alpha-V	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Parkin	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-synuclein	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
neuropeptide S receptor isoform A	1	0	0	1
Prothrombin	0	0	1	1
Adenosine receptor A1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	1	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Chloroquine resistance transporter	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Context

Research

Studies (316)

Protein Targets (675)

High T4 Syndrome

Synonyms(8)

Research Excerpts

Overview

Context

Research

Studies (316)

Drugs Studied (100)

Protein Targets (675)