Page last updated: 2024-09-27

Hereditary Breast and Ovarian Cancer Syndrome

Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers.

Synonyms(1)

Synonym
Hereditary Breast and Ovarian Cancer Syndrome

Research

Studies (21)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's14 (66.67)28.8240
2020's7 (33.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrogen carbonate0low10
aspirin0low10
metformin0low10
mitomycin0low10
carboplatin0medium22
tamoxifen0low10
osteoprotegerin0low10
iniparib0low10
exudates0low10

Protein Targets (346)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase1001
GLS protein1001
AR protein5005
aldehyde dehydrogenase 1 family, member A11001
thyroid stimulating hormone receptor1001
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 43003
EWS/FLI fusion protein6006
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha3003
estrogen nuclear receptor alpha6006
cytochrome P450 2D63003
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 23003
Bloom syndrome protein isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0404
Epidermal growth factor receptor0303
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Fatty acid-binding protein, liver0101
Integrin beta-31203
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-11102
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10404
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
acetylcholinesterase2002
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma3003
estrogen receptor 2 (ER beta)3003
G1001
vitamin D3 receptor isoform VDRA2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 12002
histone acetyltransferase KAT2A isoform 12002
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 1001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase1001
PPM1D protein3003
TDP1 protein4004
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear receptor subfamily 1, group I, member 23003
thyroid hormone receptor beta isoform 24004
Cellular tumor antigen p534004
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
tyrosine-protein kinase Yes1001
Chain A, Ferritin light chain2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
geminin4004
lamin isoform A-delta102002
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Multidrug and toxin extrusion protein 10101
hypoxia-inducible factor 1 alpha subunit2002
Fumarate hydratase2002
GLI family zinc finger 32002
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor2002
polyprotein2002
67.9K protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
caspase-32002
Histone H2A.x2002
nuclear factor erythroid 2-related factor 2 isoform 21001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Voltage-dependent calcium channel gamma-2 subunit2002
Indoleamine 2,3-dioxygenase 10101
Glutamate receptor 22002
Spike glycoprotein2013
Poly [ADP-ribose] polymerase tankyrase-10213
Cytochrome P450 1A20101
Cholinesterase0101
Poly [ADP-ribose] polymerase 10448
Cytochrome P450 2D60101
Protein mono-ADP-ribosyltransferase PARP60101
Protein mono-ADP-ribosyltransferase PARP150101
Protein mono-ADP-ribosyltransferase PARP100224
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160123
Protein mono-ADP-ribosyltransferase PARP120202
Poly [ADP-ribose] polymerase tankyrase-20213
Histamine H3 receptor0101
Poly [ADP-ribose] polymerase 20347
Protein mono-ADP-ribosyltransferase PARP40224
Protein mono-ADP-ribosyltransferase PARP30246
Chain A, Beta-lactamase2002
Genome polyprotein 0101
Luciferase1001
pregnane X receptor1001
pregnane X nuclear receptor2002
NPC intracellular cholesterol transporter 1 precursor2002
peripheral myelin protein 221001
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20202
Tyrosine-protein kinase Fyn0202
Integrin alpha-V 0101
Tubulin beta chain0113
ATP-dependent translocase ABCB10316
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0404
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Serum paraoxonase/arylesterase 10101
Cholecystokinin receptor type A0202
Melanocortin receptor 50404
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0404
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
Chain A, CES1 protein0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
SMAD family member 21001
USP1 protein, partial1001
SMAD family member 31001
Microtubule-associated protein tau1001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
regulator of G-protein signaling 41001
bromodomain adjacent to zinc finger domain 2B1001
arylsulfatase A1001
thyroid stimulating hormone receptor1001
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
chromobox protein homolog 11001
transcriptional regulator ERG isoform 31001
caspase-31001
heat shock protein beta-11001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear receptor ROR-gamma isoform 11001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Progesterone receptor0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
5-hydroxytryptamine receptor 1A0202
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
Gamma-aminobutyric acid receptor subunit alpha-61001
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Alpha-synuclein1001
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
GABA theta subunit1001
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon1001
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Protein mono-ADP-ribosyltransferase PARP140101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]