Page last updated: 2024-09-27

Hematomyelia

Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD, such as the anterior and paired posterior spinal arteries or their many branches. Disease processes may include ATHEROSCLEROSIS; EMBOLISM; and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia).

Synonyms(4)

Synonym
Posterior Spinal Artery Syndrome
Vascular Diseases, Spinal Cord
Spinal Cord Vascular Diseases
Hematomyelia

Research Excerpts

Treatment

ExcerptReference
"We describe a patient with hematomyelia, review the literature on hematomyelia and other intraspinal hemorrhage syndromes, and summarize intraspinal hemorrhage associated with oral anticoagulant therapy."( Baskharoun, R; Kalapura, T; Pincus, M; Pullarkat, VA, 2000)
"We report a patient with cervical hematomyelia associated with oral anticoagulant therapy, which is a very rare case."( Basak, M; Cakirer, S; Galip, GM, 2001)
"Only few other cases of hematomyelia linked to anticoagulant therapy have been reported."( Famularo, G; Gasbarrone, L; Sajeva, MR, 2014)

Research

Studies (14)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (7.14)23.3326
1990's0 (0.00)12.5806
2000's6 (42.86)18.1394
2010's4 (28.57)28.8240
2020's3 (21.43)9.53
DrugIndicatedRelationship StrengthStudiesTrials
coumarin0low10
aspirin0low10
methylprednisolone0low10
enbucrilate0low10
magnesium sulfate0low10
fibrinogen0low10
vitamin k semiquinone radical0low10
dexmedetomidine0low10
rivaroxaban0low10
apixaban0low10
indocyanine green0low10
dicumarol0low10
warfarin0low50
phenprocoumon0low10

Protein Targets (230)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)0101
EWS/FLI fusion protein3003
Coagulation factor X0101
Prothrombin0202
Coagulation factor X0404
Trypsin-10101
Trypsin-20101
Trypsin-30101
Spike glycoprotein2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase2002
GLS protein1001
AR protein4004
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor3003
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 42002
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 12002
estrogen-related nuclear receptor alpha4004
estrogen nuclear receptor alpha5005
cytochrome P450 2D62002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta2002
Rac1 protein0011
IDH12002
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 23003
Bloom syndrome protein isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0707
Epidermal growth factor receptor0101
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Fatty acid-binding protein, liver0101
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0102
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12103
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10303
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
Chain A, Beta-lactamase3003
pregnane X receptor1001
USP1 protein, partial3003
GALC protein1001
retinoid X nuclear receptor alpha2002
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
nuclear receptor subfamily 1, group I, member 22002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 12002
peripheral myelin protein 223003
glycogen synthase kinase-3 alpha0001
muscleblind-like protein 1 isoform 12002
lamin isoform A-delta102002
Exportin-10101
Carbonic anhydrase 120102
Glyceraldehyde-3-phosphate dehydrogenase0101
NAD-dependent histone deacetylase SIR20103
Carbonic anhydrase 30101
Cytochrome P450 2A60001
Aldo-keto reductase family 1 member B10101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Amine oxidase [flavin-containing] B0101
Cytochrome P450 2A50001
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Acetylcholinesterase0101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
UDP-glucuronosyltransferase 2B10 0101
Carbonic anhydrase 70101
Quinone oxidoreductase0001
Beta-secretase 10101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Carbonic anhydrase 90102
Zn finger protein 0101
Dihydroorotate dehydrogenase 0101
Carbonic anhydrase 130101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Alpha-2A adrenergic receptor0112
Gamma-aminobutyric acid receptor subunit beta-12002
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Alpha-2C adrenergic receptor0112
Alpha-2B adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Alpha-1A adrenergic receptor0101
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Luciferase1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma2002
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 31001
G2002
peroxisome proliferator activated receptor gamma2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-11001
geminin3003
Voltage-dependent calcium channel gamma-2 subunit1001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p532002
NAD0101
Cholinesterase0101
Urease0101
Cytochrome P450 2C9 0303
NAD0102
Glutamate receptor 21001
Mitogen-activated protein kinase 10101
ATP phosphoribosyltransferase0101
Proprotein convertase subtilisin/kexin type 70202
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Integrase 0101
Inositol hexakisphosphate kinase 12002
G-protein coupled receptor 350112
cytochrome P450 2C9, partial2002
acetylcholinesterase1001
PPM1D protein2002
GLI family zinc finger 32002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
progesterone receptor2002
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B1001
nuclear factor erythroid 2-related factor 2 isoform 21001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase1001
Gag-Pol polyprotein0101
Cytochrome P450 2D60101
Gag-Pol polyprotein0101
Protease 0303
Chain A, Activated Factor Xa Heavy Chain0101
Coagulation factor XII0101
Suppressor of tumorigenicity 14 protein0101
Chain A, Ferritin light chain1001
thioredoxin glutathione reductase1001
vitamin D3 receptor isoform VDRA1001
chromobox protein homolog 11001
histone acetyltransferase KAT2A isoform 11001
Rap guanine nucleotide exchange factor 31001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Albumin0011
Albumin0011
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]