Hematomyelia

Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD, such as the anterior and paired posterior spinal arteries or their many branches. Disease processes may include ATHEROSCLEROSIS; EMBOLISM; and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia).

Synonyms(4)

Synonym
Posterior Spinal Artery Syndrome
Vascular Diseases, Spinal Cord
Spinal Cord Vascular Diseases
Hematomyelia

Research Excerpts

Treatment

Excerpt	Reference
"We describe a patient with hematomyelia, review the literature on hematomyelia and other intraspinal hemorrhage syndromes, and summarize intraspinal hemorrhage associated with oral anticoagulant therapy."	( Baskharoun, R; Kalapura, T; Pincus, M; Pullarkat, VA, 2000)
"We report a patient with cervical hematomyelia associated with oral anticoagulant therapy, which is a very rare case."	( Basak, M; Cakirer, S; Galip, GM, 2001)
"Only few other cases of hematomyelia linked to anticoagulant therapy have been reported."	( Famularo, G; Gasbarrone, L; Sajeva, MR, 2014)

Research

Studies (14)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (7.14)	23.3326
1990's	0 (0.00)	12.5806
2000's	6 (42.86)	18.1394
2010's	4 (28.57)	28.8240
2020's	3 (21.43)	9.53

Drug	Relationship Strength	Studies
coumarin	low	1
aspirin	low	1
methylprednisolone	low	1
enbucrilate	low	1
magnesium sulfate	low	1
fibrinogen	low	1
vitamin k semiquinone radical	low	1
dexmedetomidine	low	1
rivaroxaban	low	1
apixaban	low	1
indocyanine green	low	1
dicumarol	low	1
warfarin	low	5
phenprocoumon	low	1

Protein Targets (230)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	3	0	0	3
Coagulation factor X	0	1	0	1
Prothrombin	0	2	0	2
Coagulation factor X	0	4	0	4
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Spike glycoprotein	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
AR protein	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
estrogen-related nuclear receptor alpha	4	0	0	4
estrogen nuclear receptor alpha	5	0	0	5
cytochrome P450 2D6	2	0	0	2
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	7	0	7
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
pregnane X receptor	1	0	0	1
USP1 protein, partial	3	0	0	3
GALC protein	1	0	0	1
retinoid X nuclear receptor alpha	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
peripheral myelin protein 22	3	0	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	2	0	0	2
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	1	0	2
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Alpha-2A adrenergic receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Histamine H2 receptor	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Luciferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	2	0	0	2
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
G	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
heat shock protein beta-1	1	0	0	1
geminin	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Cellular tumor antigen p53	2	0	0	2
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
NAD	0	1	0	2
Glutamate receptor 2	1	0	0	1
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
G-protein coupled receptor 35	0	1	1	2
cytochrome P450 2C9, partial	2	0	0	2
acetylcholinesterase	1	0	0	1
PPM1D protein	2	0	0	2
GLI family zinc finger 3	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
progesterone receptor	2	0	0	2
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	1	0	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
chromobox protein homolog 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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