Hematoma, Epidural, Spinal

A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.

Synonym
Hemorrhage, Spinal Epidural
Spinal Epidural Hematoma
Hematoma, Epidural, Spinal

Excerpt	Reference
"Spontaneous spinal epidural hematoma is a rarity in the literature with a variety of etiologies."	( Garges, KJ; Nourbakhsh, A, 2007)
"Spontaneous spinal epidural hematoma is a rare condition of spinal cord compression, and emergent decompressive surgery is strictly indicated."	( Chen, GJ; Chiang, YH; Hsieh, CT; Liu, WH, 2008)
"Spinal epidural hematoma is a rare and devastating complication of epidural catheter removal in an anticoagulated patient."	( Aviv, RI; Awad, IT; Eipe, N; Restrepo-Garces, CE, 2009)
"While spontaneous spinal epidural hematomas are rare, 1 of the identified risk factors is vitamin K antagonist therapy."	( Bernard, C; Cruc, M; Esnault, P; Gaillard, PE; Mathais, Q; Prunet, B, 2018)
"Spinal epidural hematoma is a rare condition usually secondary to trauma and coagulopathy."	( Battaglia, P; Cooper, J; Reiter, T, 2019)
"Spinal epidural hematomas are rare, with trauma being the most common cause."	( Bi, W; Ding, W; Li, X; Wang, L; Xu, Y; Yang, W; Yang, Y; Zeng, Z, 2022)

Excerpt	Reference
"To describe a case of spinal epidural hematoma arising from the synovial joint due to anticoagulation therapy."	( Garges, KJ; Nourbakhsh, A, 2007)
"We report a case of spontaneous spinal epidural hematoma (SSEH) in a 60-yr-old woman who was treated with clopidogrel for frequent transient ischemic attacks."	( Hong, JT; Lee, SW; Son, BC; Sung, JH, 2007)
"Spontaneous spinal epidural hematoma (SEH) has not been reported under anti-thrombotic therapy with acetyl-salicylic acid (ASA) in a dosage of 50 mg/d."	( Finsterer, J; Kleinpeter, G; Krugluger, W; Seywald, S; Stöllberger, C; Tscherney, R; Ulram, A, 2008)
"Spontaneous spinal epidural hematoma (SSEH) is a rare condition requiring urgent diagnosis and treatment."	( Arslan, E; Kahraman, S; Sirin, S; Yasar, S, 2010)
"While spontaneous spinal epidural hematomas are rare, 1 of the identified risk factors is vitamin K antagonist therapy."	( Bernard, C; Cruc, M; Esnault, P; Gaillard, PE; Mathais, Q; Prunet, B, 2018)
"We present a case of a spontaneous spinal epidural hematoma occurring in a patient under treatment with dabigatran, a non-vitamin K oral anticoagulant."	( Bernard, C; Cruc, M; Esnault, P; Gaillard, PE; Mathais, Q; Prunet, B, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (2.33)	23.3326
1990's	0 (0.00)	12.5806
2000's	53 (41.09)	18.1394
2010's	61 (47.29)	28.8240
2020's	12 (9.30)	9.53

Drug	Relationship Strength	Studies	Trials
protocatechuic acid	low	1	0
beta-alanine	low	2	0
coumarin	low	1	0
dalteparin	low	17	0
nitrous oxide	low	1	0
aspirin	low	20	0
cilostazol	low	2	0
fentanyl	low	1	0
glyburide	low	3	0
lidocaine	low	1	0
ifosfamide	low	1	0
propofol	low	2	0
sevoflurane	low	1	0
ticlopidine	low	17	0
prednisolone	low	1	0
prednisone	low	1	0
adenosine diphosphate	low	1	0
methylprednisolone	low	11	0
thiophenes	low	6	0
titanium	low	1	0
ozone	low	1	0
paclitaxel	low	1	0
captopril	low	1	0
fomesafen	low	1	0
clopidogrel	low	18	0
remifentanil	low	1	0
ketorolac tromethamine	medium	1	1
fibrinogen	low	1	0
entonox	low	1	0
imatinib mesylate	low	1	0
carbapenems	low	1	0
dabigatran	low	5	0
fibrin	low	1	0
rocuronium	low	1	0
buprenorphine	low	1	0
1-n-methyl-5-thiotetrazole	low	1	0
vitamin k semiquinone radical	low	1	0
menatetrenone	low	1	0
fondaparinux	low	3	0
menaquinone 6	low	1	0
morphine	low	1	0
deamino arginine vasopressin	low	1	0
gadolinium dtpa	low	2	0
ticagrelor	low	1	0
rivaroxaban	low	11	0
apixaban	low	4	0
piperidines	low	1	0
dicumarol	low	1	0
warfarin	low	17	0
hirudin	low	1	0
thromboplastin	low	1	0

Protein Targets (689)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	11	0	0	11
GLI family zinc finger 3	16	0	0	16
progesterone receptor	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	4	0	0	4
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	6	3	10
Delta-type opioid receptor	0	8	2	11
Kappa-type opioid receptor	0	7	2	10
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
acetylcholinesterase	5	0	0	5
phosphopantetheinyl transferase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	1	0	0	1
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	2	0	0	2
PPM1D protein	3	0	0	3
SMAD family member 3	6	0	0	6
TDP1 protein	12	0	0	12
Thrombopoietin	3	0	0	3
AR protein	21	0	0	21
caspase 7, apoptosis-related cysteine protease	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	6	0	0	6
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
EWS/FLI fusion protein	10	0	0	10
glucocorticoid receptor [Homo sapiens]	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	23	0	0	23
G	11	0	0	11
cytochrome P450 2D6	9	0	0	9
polyprotein	1	0	0	1
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	8	0	0	8
caspase-3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
thyroid stimulating hormone receptor	5	0	0	5
Histone H2A.x	6	0	0	6
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
D(1A) dopamine receptor	3	0	0	3
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
thyroid hormone receptor beta isoform 2	12	0	0	12
heat shock protein beta-1	5	0	0	5
huntingtin isoform 2	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
geminin	13	0	0	13
peripheral myelin protein 22	8	0	0	8
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	3	0	0	3
lamin isoform A-delta10	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	8	1	1	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Lysine-specific demethylase PHF2	0	1	0	1
Bile salt export pump	0	22	0	22
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Cellular tumor antigen p53	10	0	0	10
Integrin beta-3	2	2	0	4
Tyrosine-protein kinase Fyn	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	6	1	9
Integrin alpha-IIb	2	1	0	3
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	5	1	6
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2C8	0	4	0	5
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	8	1	1	10
Alpha-1B adrenergic receptor	0	4	0	4
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	1	10
Muscarinic acetylcholine receptor M3	0	4	0	4
ATP-dependent translocase ABCB1	0	3	0	3
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	1	10
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	6	1	7
Histamine H2 receptor	0	2	0	2
Endothelin-1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	1	10
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	1	10
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	6	2	8
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	4	0	4
D(3) dopamine receptor	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Squalene synthase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	0	4
Histamine H2 receptor	4	0	0	4
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	4	0	4
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	8	2	1	11
Gamma-aminobutyric acid receptor subunit beta-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-2	8	1	1	10
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	4	1	5
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	8	1	1	10
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	11	0	0	11
Canalicular multispecific organic anion transporter 1	0	13	0	13
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	7	0	0	7
Sigma non-opioid intracellular receptor 1	0	9	1	10
Gamma-aminobutyric acid receptor subunit epsilon	8	1	1	10
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	11	0	0	11
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
Coagulation factor X	0	1	0	1
Prothrombin	0	5	0	5
Coagulation factor X	0	6	0	6
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Trypsin-3	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	10	0	0	10
GLS protein	6	0	0	6
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
glucocerebrosidase	1	0	0	1
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	8	0	0	8
DNA polymerase kappa isoform 1	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	0	6
Fatty acid-binding protein, liver	0	3	0	3
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	2
Prostaglandin G/H synthase 2	0	6	0	6
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Cytochrome P450 3A4	0	3	1	5
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
pregnane X receptor	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
galanin receptor type 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Glutamate receptor 2	7	0	0	7
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	2	4
Potassium channel subfamily K member 9	0	1	0	1
Kappa-type opioid receptor	0	5	0	5
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
15-lipoxygenase, partial	1	0	0	1
Microtubule-associated protein tau	5	0	0	5
thioredoxin glutathione reductase	5	0	0	5
Metallo-beta-lactamase type 2	0	1	1	2
peripheral myelin protein 22 isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	2	1	3
Angiotensin-converting enzyme	0	4	0	5
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	4	1	5
TAR DNA-binding protein 43	1	0	0	1
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
Beta-lactamase class B VIM-2	0	1	1	2
endonuclease IV	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Cytochrome P450 2C9	0	9	0	9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
nonstructural protein 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Cytochrome P450 2C19	0	4	0	4
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	3	0	3
Chain A, Beta-lactamase	6	0	0	6
GALC protein	2	0	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	2	0	3
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	2	0	2
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	2	0	3
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Plasminogen	0	1	0	1
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
cytochrome P450 2C19 precursor	3	0	0	3
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
NAD	0	2	0	3
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Protease	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	2	11
Kappa-type opioid receptor	0	3	1	5
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Caspase-7	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
caspase-3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Albumin	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium-dependent serotonin transporter	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Cytochrome P450 2J2	0	4	0	4
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
Bile salt export pump	0	3	0	3
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Serum paraoxonase/arylesterase 1	0	2	0	2
glp-1 receptor, partial	3	0	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	2	1	3
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Albumin	0	1	1	2
Fatty acid-binding protein, intestinal	0	1	1	2
Caspase-1	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Smad3	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cruzipain	0	1	0	1
Alpha-synuclein	0	1	0	1
Vitamin K-dependent gamma-carboxylase	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Genome polyprotein	0	1	0	1
67.9K protein	1	0	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	3	0	0	3
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
activating transcription factor 6	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, Protocatechuate 3,4-dioxygenase alpha chain	0	0	1	1
Chain B, Protocatechuate 3,4-dioxygenase beta chain	0	0	1	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
DNA polymerase beta	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Polyphenol oxidase 2	0	1	0	1
3-dehydroquinate synthase	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Matrilysin	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Alpha-glucosidase MAL12	0	1	0	1
Anthrax toxin receptor 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
P2Y purinoceptor 13	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
arylsulfatase A	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (129)

Protein Targets (689)

Hematoma, Epidural, Spinal

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (129)

Drugs Studied (63)

Protein Targets (689)