HIV Wasting Syndrome

Involuntary weight loss of greater than 10 percent associated with intermittent or constant fever and chronic diarrhea or fatigue for more than 30 days in the absence of a defined cause other than HIV infection. A constant feature is major muscle wasting with scattered myofiber degeneration. A variety of etiologies, which vary among patients, contributes to this syndrome. (From Harrison's Principles of Internal Medicine, 13th ed, p1611).

Synonym
HIV Wasting Syndrome

Excerpt	Reference
"Although the HIV wasting syndrome has become a far less common manifestation of advanced disease since the introduction of highly active therapies, much has been learned about a number of potential therapeutic interventions."	( Abrams, DI, 2000)

Excerpt	Reference
"The first step to treating HIV wasting syndrome is to provide appropriate antiretroviral therapy, including meticulous prophylaxis and treatment of opportunistic infections (OIs)."	( Reiter, GS, 1996)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	95 (47.50)	12.5806
2000's	98 (49.00)	18.1394
2010's	7 (3.50)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
carnitine	low	1	0
lactic acid	low	2	0
glycerol	low	1	0
pyruvic acid	low	1	0
urea	low	2	0
alendronate	low	2	0
azathioprine	low	1	0
brl 42810	low	1	0
fenfluramine	low	1	0
ketotifen	medium	1	1
nevirapine	low	1	0
pamidronate	low	1	0
pentoxifylline	low	1	0
risperidone	low	1	0
delavirdine	low	1	0
prednisone	medium	2	1
oxandrolone	medium	17	4
glutamine	medium	5	1
lysine	medium	2	1
leucine	low	2	0
ornithine	medium	1	1
arginine	low	5	0
nandrolone	medium	15	9
2-aminopurine	low	1	0
dihydrotestosterone	low	1	0
dehydroepiandrosterone sulfate	low	2	0
d-alpha tocopherol	low	1	0
dronabinol	medium	6	1
stavudine	medium	8	1
megestrol	low	1	0
zidovudine	low	8	0
pravastatin	low	1	0
lamivudine	low	4	0
efavirenz	low	1	0
nelfinavir	low	2	0
3-methylhistidine	medium	1	1
biocytin	medium	1	1
valerates	low	1	0
alanylglutamine	medium	1	1
xylose	medium	3	1
trimethoprim, sulfamethoxazole drug combination	low	1	0
ritonavir	medium	2	1
saquinavir	medium	2	2
cystine	low	1	0
calcitriol	low	1	0
oxymetholone	medium	4	1
humulene	low	7	0
indinavir sulfate	medium	2	1
cysteine	low	1	0
sincalide	low	1	0
ornithine alpha-ketoglutarate	medium	1	1
cosyntropin	low	1	0
beta-endorphin	low	1	0
th9507	low	1	0
tipranavir	low	1	0
transforming growth factor beta	low	4	0
vitamin b 12	low	1	0
chondroitin sulfates	low	1	0
neopterin	medium	3	2
didanosine	low	1	0
ganciclovir	low	2	0
eye	low	1	0
leptin	low	2	0

Protein Targets (642)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	5	0	0	5
thioredoxin reductase	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
IDH1	4	0	0	4
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	4	0	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	4	0	4
Acetylcholinesterase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	3	0	0	3
NFKB1 protein, partial	3	0	0	3
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	8	0	0	8
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	12	0	16
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	8	0	0	8
interleukin 8	3	0	0	3
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	14	0	0	14
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	3	0	0	3
SMAD family member 3	8	0	0	8
TDP1 protein	20	0	0	20
GLI family zinc finger 3	16	0	0	16
Microtubule-associated protein tau	7	0	0	7
AR protein	20	0	0	20
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
EWS/FLI fusion protein	9	0	0	9
glucocorticoid receptor [Homo sapiens]	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	13	0	0	13
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	9	0	0	9
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	28	0	0	28
G	10	0	0	10
polyprotein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
arylsulfatase A	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	6	0	0	6
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	18	0	0	18
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
geminin	14	0	0	14
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	16	0	0	16
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	19	0	20
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	21	0	21
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Cellular tumor antigen p53	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Glutamate receptor 2	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Nuclear receptor ROR-gamma	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
GABA theta subunit	5	0	0	5
Inositol hexakisphosphate kinase 1	10	0	0	10
Canalicular multispecific organic anion transporter 1	0	18	0	18
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	10	0	0	10
regulator of G-protein signaling 4	3	0	0	3
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Cruzipain	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
relaxin receptor 1 isoform 1	2	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	4	0	0	4
PPM1D protein	2	0	0	2
mitogen-activated protein kinase 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Androgen receptor	0	5	2	9
Cytochrome P450 2D6	0	4	0	4
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	4	0	5
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	2	0	2
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
estrogen receptor 2 (ER beta)	9	0	0	9
progesterone receptor	10	0	0	10
cytochrome P450 2D6	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
Sex hormone-binding globulin	0	1	3	4
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	3	0	3
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Alpha-synuclein	1	0	0	1
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	6
Solute carrier family 22 member 11	0	1	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	2
Solute carrier organic anion transporter family member 1B1	0	4	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Gag-Pol polyprotein	0	10	0	10
Malate dehydrogenase, cytoplasmic	0	1	0	1
Reverse transcriptase/RNaseH	0	8	7	29
Integrase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	5
67.9K protein	3	0	0	3
thyroid hormone receptor beta isoform a	7	0	0	7
Albumin	0	0	4	12
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
glp-1 receptor, partial	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Plasma kallikrein	0	1	0	1
Glucocorticoid receptor	0	5	1	7
Progesterone receptor	0	1	0	1
Progesterone receptor	0	1	1	2
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	0	1	0	1
Sex hormone-binding globulin	0	1	0	1
Aromatase	0	1	0	2
Androgen receptor	0	10	1	11
Androgen receptor	0	1	1	2
Mineralocorticoid receptor	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	2	1	3
Muscarinic acetylcholine receptor	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	1
ALK tyrosine kinase receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	0	1	1
Glutamate receptor 3	0	0	1	1
Glutamate receptor 4	0	0	1	1
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 2	0	2	1	4
D(3) dopamine receptor	0	6	1	7
Cannabinoid receptor 1	0	3	0	3
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
neuropeptide S receptor isoform A	3	0	0	3
Prothrombin	0	2	0	2
Gag-Pol polyprotein	0	8	0	8
5-hydroxytryptamine receptor 1A	0	6	0	8
Cytochrome P450 2B6	0	0	0	1
Acetylcholinesterase	0	0	0	2
Microsomal triglyceride transfer protein large subunit	0	2	0	2
Spike glycoprotein	7	0	0	7
Disintegrin and metalloproteinase domain-containing protein 17	1	2	0	3
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Protease	0	11	5	31
Fructose-1,6-bisphosphatase 1	0	0	0	2
Reverse transcriptase	0	2	2	4
Cholesterol 24-hydroxylase	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Thymidine kinase	0	1	0	1
endonuclease IV	3	0	0	3
ClpP	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
Solute carrier family 22 member 1	0	3	0	4
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 3	0	2	0	2
Gag-Pol polyprotein	0	6	0	6
Gag-Pol polyprotein	0	3	0	3
Gag polyprotein	0	2	0	2
Gag-Pol polyprotein	0	4	0	4
ATP-dependent translocase ABCB1	0	4	0	5
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	3	0	3
Alpha-1B adrenergic receptor	0	6	0	6
Substance-K receptor	0	8	0	8
Alpha-1D adrenergic receptor	0	5	0	5
Thromboxane-A synthase	0	4	0	4
Gag-Pol polyprotein	0	4	0	4
Alpha-1A adrenergic receptor	0	6	0	6
Thromboxane-A synthase	0	0	0	3
Genome polyprotein	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
Protease	0	9	4	14
Protease	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Glutathione reductase, mitochondrial	0	3	0	3
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	6	0	6
UDP-glucuronosyltransferase 1A4	0	0	0	1
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	6	0	6
Histamine H1 receptor	0	4	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	3	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Hsf1 protein	0	0	2	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
bioA	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
DNA polymerase beta	4	0	0	4
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
glucocerebrosidase	2	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Chain A, ASPARTYLPROTEASE	0	1	0	1
Chain B, ASPARTYLPROTEASE	0	1	0	1
Smad3	4	0	0	4
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
Epidermal growth factor receptor	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Cruzipain	0	1	0	1
Mitogen-activated protein kinase 3	0	1	0	1
Mu-type opioid receptor	0	6	0	6
Delta-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	6	0	6
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain B, Hiv-1 Reverse Transcriptase	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Renin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Imidazoleglycerol-phosphate dehydratase	0	1	0	1
Ryanodine receptor 1	0	1	0	1
Exoribonuclease H	0	2	0	2
Cardiac ryanodine receptor 2	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Luciferase	2	0	0	2
dopamine D1 receptor	1	0	0	1
vasopressin V1b receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Chitotriosidase-1	0	2	1	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Endochitinase B1	0	2	1	3
Solute carrier family 22 member 6	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	4	0	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Insulin receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Solute carrier family 22 member 7	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	1	0	2
pregnane X receptor	1	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Albumin	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	2	3
5-hydroxytryptamine receptor 2C	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Transporter	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Vasopressin V1a receptor	0	4	0	4
Sodium/bile acid cotransporter	0	1	0	1
Plasmepsin V	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chloroquine resistance transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Cholecystokinin receptor type A	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	2	4
Mu-type opioid receptor	0	0	1	1
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Thymidine kinase 2	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine kinase, cytosolic	0	1	0	2
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Protein (hiv-1 Protease)	0	1	0	1
Chain B, Protein (hiv-1 Protease)	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Cathepsin D	0	1	0	1
Pepsin A-5	0	1	0	1
Cathepsin E	0	1	0	1
CAAX prenyl protease 1 homolog	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Context

Treatment

Research

Studies (200)

Protein Targets (642)

HIV Wasting Syndrome

Synonyms(1)

Research Excerpts

Context

Treatment

Research

Studies (200)

Drugs Studied (85)

Protein Targets (642)