Amyoplasia Congenita

Synonym
Congenital Arthromyodysplasia
Guu00E9rin-Stern Syndrome
Congenital Multiple Arthrogryposis
Fibrous Ankylosis of Multiple Joints
Rossi Syndrome
Arthrogryposis
Myodystrophia Fetalis Deformans
Arthrogryposis Multiplex Congenita (AMC)
Amyoplasia Congenita
Arthrogryposis Multiplex Congenita
Arthromyodysplasia, Congenital
Rocher-Sheldon Syndrome
Guerin-Stern Syndrome
Otto Syndrome

Excerpt	Reference
"Arthrogryposis multiplex congenita is a rare disorder of skeletal muscle development which is characterized by deforming contractures of the joints, but seldom affects the temporomandibular joint."	( Claman, L; Horton, JE; Klabunde, M; Perry, T; Sakamoto, FO, 1985)
"A study of distal arthrogryposis is described including neurology, electromyography, cerebral and muscular CT-scanning, and muscle and nerve biopsies."	( Hageman, G; Jennekens, FG; Vette, JK; Willemse, J, 1984)
"Arthrogryposis multiplex congenita is a heterogeneous condition found in a number of different disorders and characterized by congenital joint contractures."	( Chiarelli, FE; Della Loggia, GE; Di Muzio, AE; Gallenga, PE; Lobefalo, LT; Mancini, AT; Petitti, MT; Verrotti, AE, 1999)
"Arthrogryposis is characterized by multiple, nonprogressive joint contractures which may be caused by maternal disorders such as oligohydramnios as well as fetal akinesia resulting from primary disorders of muscle, connective tissue, or neurologic tissue."	( Anderson, TA; Holzman, RS; Kasser, JR, 2014)
"Distal arthrogryposis is the second most common type of arthrogryposis after amyoplasia and is defined as arthrogryposis that affects hands and feet; it is mostly inherited in an autosomal-dominant fashion."	( Alzahrani, MA; Farr, S, 2022)

Excerpt	Reference
"Arthrogryposis has an evil reputation among orthopedic surgeons, for the deformities are known to be resistant to correction and relapse during growth is common."	( Williams, P, 1978)
"Arthrogryposis multiplex congenita has been linked with malignant hyperthermia."	( Baines, DB; Douglas, ID; Overton, JH, 1986)

Excerpt	Reference
"The purpose of treatment of arthrogryposis of the lower extremities is to achieve a stable functional weight bearing position of the affected joints."	( Oh, WH, 1976)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	74 (44.85)	23.3326
1990's	17 (10.30)	12.5806
2000's	19 (11.52)	18.1394
2010's	36 (21.82)	28.8240
2020's	19 (11.52)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
carbamates	low	1	0
carbon monoxide	low	1	0
aminocaproic acid	low	1	0
glycine	low	4	0
nitrous oxide	low	2	0
acetaminophen	low	1	0
acetazolamide	low	1	0
baclofen	low	1	0
bupivacaine	low	2	0
carbamazepine	low	1	0
diazepam	low	1	0
diazoxide	low	1	0
ddt	low	1	0
fentanyl	low	1	0
gabapentin	low	2	0
halothane	low	4	0
hydrochlorothiazide	low	1	0
ketamine	low	2	0
malathion	low	1	0
methocarbamol	low	1	0
midazolam	low	1	0
apnea	low	1	0
neostigmine	low	2	0
nitroglycerin	low	1	0
nortriptyline	low	1	0
oxolinic acid	low	1	0
propofol	low	2	0
sevoflurane	low	2	0
thalidomide	low	2	0
hydroxyproline	low	1	0
prednisone	low	2	0
pilocarpine	low	1	0
aspartic acid	low	1	0
lysine	low	3	0
tubocurarine	low	2	0
asparagine	low	1	0
tryptophan	low	1	0
arginine	low	3	0
pyridostigmine bromide	low	4	0
ergotamine	low	2	0
tecnazene	low	2	0
2-naphthol	low	1	0
methohexital	low	1	0
hydrazine	low	1	0
coniine	low	3	0
dextropropoxyphene	low	1	0
anagyrine	low	1	0
fluorescein	low	1	0
manganese	low	1	0
titanium	low	1	0
calcium sulfate	low	1	0
trolamine salicylate	low	3	0
clemastine	low	1	0
phenyl acetate	low	2	0
ursodeoxycholic acid	low	2	0
vecuronium bromide	low	1	0
fomesafen	low	3	0
remifentanil	low	2	0
nicotine	low	1	0
lupanine	low	1	0
pyridinoline	low	2	0
deoxypyridinoline	low	1	0
acetaminophen, dextropropoxyphene, drug combination	low	1	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
proline	low	1	0
sedoheptulose 7-phosphate	low	1	0
anabasine	low	3	0
solanine	low	1	0
dihydropyridines	low	1	0
glycogen	low	2	0
fibrin	low	1	0
elastin	low	1	0
oxytocin	low	1	0
inositol 3-phosphate	low	3	0
rocuronium	low	1	0
ammodendrine	low	1	0
tretinoin	low	1	0
bromochloroacetic acid	low	1	0
glycosides	low	1	0
dieldrin	low	1	0
chlorogenic acid	low	1	0
thiopental	low	2	0
lithium	low	1	0
hydroxylysine	low	1	0
myelin basic protein	low	1	0
bilirubin	low	3	0
maytansine	medium	1	1
misoprostol	low	2	0
phenylephrine hydrochloride	low	2	0
acitretin	low	1	0
levetiracetam	low	1	0
morphine	low	1	0
sedoheptulose	low	1	0
cysteine	low	1	0
phosphorus	low	1	0
selenium	low	1	0
indocyanine green	low	1	0
pituitrin	low	1	0
jaw	low	1	0
nad	low	2	0
piperidines	low	9	0
tetracycline	low	1	0
eye	low	2	0

Protein Targets (824)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	6	0	0	6
RAR-related orphan receptor gamma	15	0	0	15
GLI family zinc finger 3	17	0	0	17
AR protein	20	0	0	20
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
progesterone receptor	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	25	0	0	25
peroxisome proliferator-activated receptor delta	7	0	0	7
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	9	0	0	9
thyroid hormone receptor beta isoform 2	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
DNA repair and recombination protein RadA	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Cellular tumor antigen p53	16	0	0	16
Cytochrome P450 1A2	0	3	1	5
Cytochrome P450 2A6	0	6	2	8
Sulfotransferase 1A1	0	0	0	2
Glutamate receptor 2	8	0	0	10
Cytochrome P450 2A5	0	2	0	2
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Sulfotransferase 2A1	0	0	0	1
ATAD5 protein, partial	10	0	0	10
GLS protein	10	0	0	10
Microtubule-associated protein tau	9	0	0	9
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
thyroid stimulating hormone receptor	12	0	0	12
EWS/FLI fusion protein	7	0	0	7
estrogen-related nuclear receptor alpha	20	0	0	20
peroxisome proliferator activated receptor gamma	13	0	0	13
chromobox protein homolog 1	12	0	0	12
peripheral myelin protein 22	13	0	0	13
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	8	2	19
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	4	1	8
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	3	0	3
Bile salt export pump	0	24	0	24
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	1	13
Carbonic anhydrase 2	0	6	1	13
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	4	1	8
Cytochrome P450 3A4	0	7	2	10
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2C9	0	4	1	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	9	8	2	19
Gamma-aminobutyric acid receptor subunit delta	9	8	2	19
Gamma-aminobutyric acid receptor subunit gamma-2	9	8	4	21
UDP-glucuronosyltransferase 1-6	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	9	8	2	19
Gamma-aminobutyric acid receptor subunit alpha-3	9	8	2	19
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	4	1	7
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	4	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	9	8	2	19
Gamma-aminobutyric acid receptor subunit alpha-2	9	8	2	19
Gamma-aminobutyric acid receptor subunit alpha-4	9	8	2	19
Gamma-aminobutyric acid receptor subunit gamma-3	9	8	2	19
Gamma-aminobutyric acid receptor subunit alpha-6	9	8	2	19
Carbonic anhydrase 5A, mitochondrial	0	4	1	8
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	4	1	7
Nuclear receptor ROR-gamma	6	1	1	8
Cytochrome P450 2J2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	9	8	4	21
Gamma-aminobutyric acid receptor subunit beta-3	9	8	2	19
Gamma-aminobutyric acid receptor subunit beta-2	9	8	4	21
Carbonic anhydrase 9	0	4	1	8
GABA theta subunit	9	8	2	19
Canalicular multispecific organic anion transporter 1	0	15	0	15
Carbonic anhydrase 15	0	2	0	4
Carbonic anhydrase 13	0	4	0	6
Gamma-aminobutyric acid receptor subunit epsilon	9	8	2	19
Carbonic anhydrase 14	0	4	1	8
Carbonic anhydrase 5B, mitochondrial	0	4	1	8
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	11	0	0	11
GALC protein	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
glucocorticoid receptor [Homo sapiens]	18	0	0	18
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	13	0	0	13
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
Bloom syndrome protein isoform 1	12	0	0	12
thyroid hormone receptor beta isoform a	10	0	0	10
geminin	20	0	0	20
survival motor neuron protein isoform d	7	0	0	7
muscleblind-like protein 1 isoform 1	1	0	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Androgen receptor	0	4	0	4
Translocator protein	0	4	2	7
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	6	0	7
Cytochrome P450 2C19	0	3	1	4
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	8	2	13
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	5	0	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Cholinesterase	0	3	0	3
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	7	0	7
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	6	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	5	3	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
Carbonic anhydrase 4	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
USP1 protein, partial	7	0	0	7
TDP1 protein	19	0	0	19
vitamin D3 receptor isoform VDRA	7	0	0	7
flap endonuclease 1	5	0	0	5
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	11	0	0	11
Rap guanine nucleotide exchange factor 3	4	0	0	4
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	9	0	0	9
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
regulator of G-protein signaling 4	10	0	0	10
nonstructural protein 1	2	0	0	2
D(1A) dopamine receptor	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
lamin isoform A-delta10	23	0	0	23
Plasminogen	0	2	1	3
Proton-coupled amino acid transporter 1	0	5	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	6	0	0	6
Neuronal acetylcholine receptor subunit alpha-4	1	4	3	9
Neuronal acetylcholine receptor subunit beta-2	1	4	3	9
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
neuropeptide S receptor isoform A	3	0	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	2	0	0	2
alpha-galactosidase	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	10	0	0	10
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	3	0	3
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	1	8
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	1	7
Glutamate receptor ionotropic, NMDA 2C	0	5	1	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	5	1	7
Glutamate receptor ionotropic, NMDA 3B	0	5	1	7
Glutamate receptor ionotropic, NMDA 3A	0	5	1	7
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
67.9K protein	2	0	0	2
activating transcription factor 6	6	0	0	6
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	5	0	0	5
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
thyroid stimulating hormone receptor	8	0	0	8
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
acetylcholinesterase	7	0	0	7
IDH1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
Vpr	2	0	0	2
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
1,3-beta-D-glucan synthase catalytic subunit	0	1	0	1
Histone deacetylase 3	0	3	0	3
Aldo-keto reductase family 1 member B10	0	1	0	1
Amyloid-beta precursor protein	0	2	0	2
Aldo-keto reductase family 1 member B1	0	7	0	7
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	1	3
Histone deacetylase 4	0	3	0	3
Lactoperoxidase	0	0	0	1
Histone deacetylase 1	0	3	0	3
Integrase	0	2	0	2
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
large T antigen	0	1	0	1
Thrombopoietin	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
Solute carrier family 22 member 1	0	4	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
5-hydroxytryptamine receptor 4	0	8	0	8
Integrin beta-3	2	0	0	2
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	4	0	4
Integrin alpha-IIb	2	0	0	2
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M1	0	4	2	6
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	6	0	6
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	6	0	6
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	8	0	8
Histamine H1 receptor	0	5	0	5
D(3) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	10	0	10
Histamine H2 receptor	4	1	0	6
5-hydroxytryptamine receptor 6	0	6	0	6
5-hydroxytryptamine receptor 7	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Sigma intracellular receptor 2	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
cytochrome P450 2D6	6	0	0	6
Spike glycoprotein	8	0	0	8
interleukin 8	3	0	0	3
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
farnesoid X nuclear receptor	8	0	0	8
G	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Caspase-7	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
caspase-3	3	0	0	3
heat shock protein beta-1	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
Mas-related G-protein coupled receptor member X2	0	0	2	2
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	1	4
ATP-dependent translocase ABCB1	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	4	8
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
5-hydroxytryptamine receptor 1A	0	7	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	3	7
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	4	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	0	0	0	2
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
Fumarate hydratase	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
polyprotein	1	0	0	1
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
Mitogen-activated protein kinase 14	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Thromboxane-A synthase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 5A	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	4	2	7
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	4	0	0	4
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Glutamine synthetase	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
DNA polymerase beta	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	5
Muscarinic acetylcholine receptor M3	0	4	0	5
Muscarinic acetylcholine receptor M4	0	5	0	6
Muscarinic acetylcholine receptor M5	0	4	0	5
Muscarinic acetylcholine receptor M2	0	4	0	5
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	3	0	3
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	1	1	3
dopamine D1 receptor	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Glucocorticoid receptor	0	2	2	4
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
endonuclease IV	1	0	0	1
M-phase phosphoprotein 8	3	0	0	3
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	3	0	3
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-synuclein	1	2	0	3
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Parkin	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(14)

Research Excerpts

Overview

Context

Treatment

Research

Studies (165)

Protein Targets (824)

Amyoplasia Congenita

Synonyms(14)

Research Excerpts

Overview

Context

Treatment

Research

Studies (165)

Drugs Studied (121)

Protein Targets (824)