Page last updated: 2024-09-27

Gnathostoma Infection

Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.

Synonyms(2)

Synonym
Gnathostomiasis
Gnathostoma Infection

Research Excerpts

Overview

ExcerptReference
"Gnathostomiasis is endemic in central and southern Laos, so that preventive measures should be introduced for people living in these regions."( Dekumyoy, P; Kobayashi, J; Nuamtanong, S; Phommasack, B; Sa-nguankiat, S; Thaenkham, U; Vonghachack, Y; Waikagul, J; Yoonuan, T, 2010)
"Gnathostomiasis is a foodborne zoonotic helminthic infection caused by the third-stage larvae of Gnathostoma spp."( Chotmongkoi, V; Katchanov, J; Nawa, Y; Sawanyawisuth, K, 2011)
"Although gnathostomiasis is often a systemic illness, this patient did well with apparently only localized cutaneous disease."( Dans, MJ; Elston, DM; Jarell, AD; Mathison, BA; Ruben, BS, 2011)
"Intraocular gnathostomiasis is a rare parasitic infection caused by the third-stage larvae of spiruroid nematode Gnanthostoma spp."( Dinesh, KR; Karim, S; Kumar, A; Maniyelil, J; Pillai, GS; Radhakrishnan, N; Shafi, T, 2012)
"Cutaneous gnathostomiasis is an emerging food-borne parasitic zoonosis."( Bravo, F; Chian, C; Costa, H; del Solar, M; Laga, AC; Lezcano, C; Ramos, C; Salinas, C; Salomon, M, 2013)

Treatment

ExcerptReference
"Diagnosis of Gnathostoma infection was confirmed serologically and she was treated with anthelminthic drugs and steroids."( Garg, M; Kulkarni, S; Patil, V; Sayed, R, 2015)

Research

Studies (26)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (3.85)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's20 (76.92)28.8240
2020's5 (19.23)9.53
DrugIndicatedRelationship StrengthStudiesTrials
albendazole0low170
2-propanol0low20
methylprednisolone0low10
dextrothyroxine0low110
clove0low20
eye0low20
concanavalin a0low10

Protein Targets (104)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma2002
GLI family zinc finger 33003
AR protein3003
aldehyde dehydrogenase 1 family, member A11001
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha3003
estrogen nuclear receptor alpha3003
peroxisome proliferator-activated receptor delta1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
thyroid hormone receptor beta isoform a1001
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 11001
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit2002
Glutamate receptor 22002
Chain A, Beta-lactamase1001
Luciferase1001
glp-1 receptor, partial1001
ATAD5 protein, partial1001
Fumarate hydratase1001
TDP1 protein1001
caspase 7, apoptosis-related cysteine protease1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]2002
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor1001
pregnane X nuclear receptor2002
polyprotein1001
67.9K protein1001
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
caspase-31001
IDH12002
euchromatic histone-lysine N-methyltransferase 21001
aryl hydrocarbon receptor1001
nuclear receptor subfamily 1, group I, member 22002
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 22002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 21001
histone deacetylase 9 isoform 31001
mitogen-activated protein kinase 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin3003
Vif0001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
muscleblind-like protein 1 isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A2002
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Bile salt export pump0202
Interferon beta2002
Cellular tumor antigen p531001
Integrin beta-31001
Integrin alpha-IIb1001
Methionine aminopeptidase0101
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 11001
Canalicular multispecific organic anion transporter 10202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
endonuclease IV1001
thioredoxin reductase1001
Microtubule-associated protein tau1001
nonstructural protein 12002
glucocerebrosidase1001
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase beta1001
DNA polymerase iota isoform a (long)1001
M-phase phosphoprotein 81001
Spike glycoprotein1001
acetylcholinesterase1001
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
G1001
bromodomain adjacent to zinc finger domain 2B1001
Nuclear receptor subfamily 1 group I member 20011
HLA class I histocompatibility antigen, B alpha chain 1001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Inositol hexakisphosphate kinase 11001
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]