Page last updated: 2024-09-28

Glycogen Storage Disease Type VIII

An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.

Synonyms(2)

Synonym
Glycogen Storage Disease Type VIII
Glycogenosis 8

Research

Studies (4)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (25.00)23.3326
1990's1 (25.00)12.5806
2000's1 (25.00)18.1394
2010's1 (25.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
histidine0low10
glycogen0medium30

Protein Targets (75)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
ATAD5 protein, partial1001
euchromatic histone-lysine N-methyltransferase 21001
flap endonuclease 11001
cytochrome P450 3A4 isoform 11001
histone acetyltransferase KAT2A isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Carbonic anhydrase 120001
Carbonic anhydrase 10002
Carbonic anhydrase 20002
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
GABA theta subunit1001
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Gamma-aminobutyric acid receptor subunit epsilon1001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
acetylcholinesterase1001
RAR-related orphan receptor gamma1001
AR protein1001
estrogen receptor 2 (ER beta)1001
cytochrome P450 family 3 subfamily A polypeptide 41001
retinoic acid nuclear receptor alpha variant 11001
estrogen-related nuclear receptor alpha1001
estrogen nuclear receptor alpha1001
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]