Glossoptosis, Micrognathia, and Cleft Palate

Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-expression of SOX9 TRANSCRIPTION FACTOR gene on chromosome 17q and its surrounding region is associated with the syndrome.

Synonym
Pierre-Robin Syndrome
Robin Sequence
Pierre Robin Syndrome
Glossoptosis, Micrognathia, and Cleft Palate
Pierre Robin Sequence
Pierre Robin's Sequence

Excerpt	Reference
"Pierre Robin syndrome is typically characterized by glossoptosis and retrognathia associated with cleft palate, respiratory and deglutition disturbances."	( Bedhet, N; Delaire, J; Gordeeff, A; Mercier, J; Mouzard, A, 1990)
"Pierre Robin syndrome is a triad of micrognathia, glossoptosis, and cleft palate that results in upper airway obstruction and feeding problems."	( Smith, JD, 1981)
"The pathogenesis of Robin sequence is multifactorial and syndromic in nearly half of the patients."	( Evans, AK; Mulliken, JB; Rahbar, R; Rogers, GF; Volk, MS, 2006)
"Patients with Robin sequence are best managed by a multidisciplinary team familiar with the diagnoses and treatment of difficult pediatric airways."	( Mackay, DR, 2011)
"Pierre Robin sequence is a well known craniofacial entity."	( Breugem, C; Kon, M; Mink van der Molen, AB; Paes, E; van der Molen, AB, 2012)
"Pierre Robin sequence is not a rare condition and paediatric specialists caring for respiratory related issues are likely to encounter cases in their practice."	( Almajed, A; Côté, A; Fanous, A; Lacroix, Y, 2015)
"Pierre Robin sequence is characterized by mandibular retrognathia and glossoptosis resulting in airway obstruction and feeding difficulties."	( Baylis, A; Hall, C; Khansa, I; Kirschner, RE; Madhoun, LL; Pearson, GD; Splaingard, M, 2017)

Excerpt	Reference
"A brief review of the Pierre Robin syndrome and the various methods of treatment employed for children with the condition have been outlined."	( Kelly, JR; Sorenson, HW; Turner, EG, 1978)
"Eight patients with Pierre Robin syndrome (PRS), were treated according to our management protocol."	( Augarten, A; Barzilay, Z; Sagy, M; Yahav, J, 1990)
"Charts of patients with Pierre Robin sequence who underwent unsuccessful nonoperative treatment and tongue-lip adhesion procedures by the senior author between 1989 to 1999 were reviewed."	( Amm, CA; Denny, AD; Schaefer, RB, 2004)
"Review a large series of patients with Robin sequence to document the incidence of (1) associated syndromic diagnoses; (2) co-morbid conditions; (3) frequency and type of operative management for airway compromise and feeding difficulties; and (4) possible differences in treatment between syndromic and nonsyndromic infants."	( Evans, AK; Mulliken, JB; Rahbar, R; Rogers, GF; Volk, MS, 2006)
"While reviewing treatment options for Robin sequence we were surprised to see how often different definitions were used to describe this condition."	( Breugem, CC; Mink van der Molen, AB, 2009)
"This has implications for evaluating Robin sequence, giving advice about the prognosis and genetic counseling, and refining treatment options."	( Breugem, CC; Courtemanche, DJ, 2010)
"Among infants with symptomatic Pierre Robin sequence, treatment by distraction osteogenesis is associated with a lower risk for gastrostomy placement for nutritional support."	( Chang, CC; Kumar, AR; Lough, D; Mundinger, GS; Redett, RJ; Rottgers, SA; Susarla, SM; Swanson, EW, 2017)
"A longitudinal study of newborns with Pierre Robin sequence treated at a pediatric academic medical center between 2010 and 2015 was performed."	( Baylis, A; Hall, C; Khansa, I; Kirschner, RE; Madhoun, LL; Pearson, GD; Splaingard, M, 2017)
"Some patients with Robin sequence (RS) may respond to conservative therapy, while others require surgery; however, there are currently no objective anatomical criteria to gauge surgical indication."	( Cui, Y; Mao, Z; Shu, L; Zhang, N, 2020)
"Upper airway obstruction seen in Robin Sequence (RS) is commonly treated with mandibular distraction osteogenesis (MDO)."	( Chen, K; Hammoudeh, JA; Huang, A; Jimenez, C; Kondra, K; Magee, WP; Munabi, NCO; Stanton, E; Urata, MM, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	62 (33.70)	23.3326
1990's	16 (8.70)	12.5806
2000's	24 (13.04)	18.1394
2010's	65 (35.33)	28.8240
2020's	17 (9.24)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	2	0
hydrogen carbonate	low	1	0
nitrous oxide	low	1	0
uracil	low	1	0
uric acid	low	1	0
caffeine	low	4	0
disulfiram	low	1	0
fentanyl	low	2	0
fluorouracil	low	1	0
haloperidol	low	1	0
halothane	medium	4	1
ibuprofen	low	1	0
lidocaine	low	1	0
ifosfamide	low	1	0
isoflurane	low	1	0
2-propanol	low	1	0
khellin	low	1	0
leflunomide	low	1	0
meclizine	low	1	0
methadone	low	1	0
mitoxantrone	low	1	0
apnea	low	8	0
ondansetron	low	1	0
propofol	low	3	0
sevoflurane	low	5	0
xanthurenic acid	low	1	0
prednisolone	low	1	0
bromodeoxyuridine	low	1	0
phenylalanine	low	1	0
norethindrone	low	1	0
caffeine citrate	low	1	0
mestranol	low	1	0
triparanol	low	1	0
methylprednisolone	low	1	0
isoxazoles	low	1	0
dextropropoxyphene	medium	1	1
barium sulfate	low	2	0
trolamine salicylate	low	14	0
vecuronium bromide	low	1	0
sufentanil	low	1	0
atracurium	low	2	0
alfentanil	low	1	0
fomesafen	low	1	0
remifentanil	low	1	0
nsc-172755	low	1	0
5-acetylamino-6-formylamino-3-methyluracil	low	1	0
n,n'-bis((2-chloroethyl)nitrosocarbamoyl)cystamine	low	3	0
cortisone	low	1	0
povidone-iodine	low	1	0
inositol 3-phosphate	low	63	0
rocuronium	low	1	0
retinol	low	2	0
eptifibatide	medium	1	1
arginine vasopressin	low	1	0
tamoxifen	low	1	0
phenylephrine hydrochloride	low	14	0
dexmedetomidine	low	1	0
i(3)so3-galactosylceramide	low	1	0
peplomycin	low	1	0
technetium tc 99m diphosphonate	low	1	0
jaw	low	6	0
endothelin-1	low	1	0
phosphatidylcholines	low	1	0
menotropins	low	1	0
glycolipids	low	2	0
transforming growth factor beta	low	2	0
cyclin d1	low	1	0
exudates	low	1	0
eye	low	1	0

Protein Targets (736)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	20	0	0	20
GLI family zinc finger 3	18	0	0	18
AR protein	21	0	0	21
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
retinoid X nuclear receptor alpha	15	0	0	15
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
Histone H2A.x	10	0	0	10
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Glutamate receptor 2	13	0	0	13
Bile salt export pump	0	17	0	17
ATP-dependent translocase ABCB1	0	9	1	11
Mu-type opioid receptor	0	9	1	10
Kappa-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	6	0	6
thioredoxin reductase	9	0	0	9
ATAD5 protein, partial	8	0	0	8
TDP1 protein	19	0	0	19
Microtubule-associated protein tau	7	0	0	7
estrogen-related nuclear receptor alpha	22	0	0	22
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
Bloom syndrome protein isoform 1	5	0	0	5
D(1A) dopamine receptor	5	0	0	5
neuropeptide S receptor isoform A	3	0	0	3
vitamin D3 receptor isoform VDRA	6	0	0	6
peripheral myelin protein 22	14	0	0	14
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Translocator protein	0	0	1	1
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	13	0	13
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
interleukin 8	3	0	0	3
pregnane X receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	14	0	0	14
glucocorticoid receptor [Homo sapiens]	16	0	0	16
pregnane X nuclear receptor	18	0	0	18
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
IDH1	10	0	0	10
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
cellular tumor antigen p53 isoform a	7	0	0	7
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
thyroid hormone receptor beta isoform 2	14	0	0	14
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	17	0	0	17
survival motor neuron protein isoform d	6	0	0	6
muscarinic acetylcholine receptor M1	9	0	0	9
Thymidine kinase, cytosolic	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Spike glycoprotein	6	1	2	9
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	10	0	0	10
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
phosphopantetheinyl transferase	7	0	0	7
GLS protein	7	0	0	7
farnesoid X nuclear receptor	9	0	0	9
thyroid stimulating hormone receptor	11	0	0	11
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
DNA polymerase beta	1	0	0	1
nuclear receptor ROR-gamma isoform 1	8	0	0	8
DNA polymerase kappa isoform 1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Potassium channel subfamily K member 2	0	2	1	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Adenosine receptor A3	0	5	0	5
Replicase polyprotein 1ab	0	4	2	6
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	2	0	2
Adenosine receptor A1	0	4	0	6
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	1	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Adenosine receptor A2a	0	3	0	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Guanine deaminase	0	2	0	2
ATP-dependent phosphofructokinase	7	0	0	7
EWS/FLI fusion protein	9	0	0	9
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
endonuclease IV	2	0	0	2
dopamine D1 receptor	2	0	0	2
regulator of G-protein signaling 4	5	0	0	5
peroxisome proliferator activated receptor gamma	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
peripheral myelin protein 22 isoform 1	5	0	0	5
flap endonuclease 1	5	0	0	5
cytochrome P450 3A4 isoform 1	11	0	0	11
M-phase phosphoprotein 8	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	11	3	1	15
Glucocorticoid receptor	0	8	1	14
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	11	3	1	15
Gamma-aminobutyric acid receptor subunit delta	11	3	1	15
Gamma-aminobutyric acid receptor subunit gamma-2	11	3	1	15
Gamma-aminobutyric acid receptor subunit alpha-5	11	3	1	15
Gamma-aminobutyric acid receptor subunit alpha-3	11	3	1	15
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	11	3	1	15
Gamma-aminobutyric acid receptor subunit alpha-2	11	3	1	15
Glycine receptor subunit alpha-3	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	11	3	1	15
Gamma-aminobutyric acid receptor subunit gamma-3	11	3	1	15
Gamma-aminobutyric acid receptor subunit alpha-6	11	3	1	15
Gamma-aminobutyric acid receptor subunit alpha-1	11	3	1	15
Gamma-aminobutyric acid receptor subunit beta-3	11	3	1	15
Gamma-aminobutyric acid receptor subunit beta-2	11	3	1	15
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	1	0	6
GABA theta subunit	11	3	1	15
Multidrug and toxin extrusion protein 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	11	3	1	15
thyroid stimulating hormone receptor	6	0	0	6
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
Alpha-2A adrenergic receptor	0	7	1	8
Alpha-1B adrenergic receptor	0	8	0	8
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1A adrenergic receptor	0	8	0	8
Histamine H2 receptor	6	0	0	7
Mas-related G-protein coupled receptor member X2	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Beta-lactamase	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	3	0	0	3
Luciferase	7	0	0	7
acetylcholinesterase	11	0	0	11
15-lipoxygenase, partial	4	0	0	4
SMAD family member 2	5	0	0	5
Fumarate hydratase	7	0	0	7
USP1 protein, partial	9	0	0	9
NFKB1 protein, partial	4	0	0	4
PPM1D protein	5	0	0	5
SMAD family member 3	5	0	0	5
Thrombopoietin	5	0	0	5
Smad3	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
caspase 7, apoptosis-related cysteine protease	6	0	0	6
estrogen receptor 2 (ER beta)	8	0	0	8
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
nonstructural protein 1	6	0	0	6
G	8	0	0	8
cytochrome P450 2D6	10	0	0	10
polyprotein	7	0	0	7
pyruvate kinase	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
caspase-3	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	3	0	0	3
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
beta-2 adrenergic receptor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	4	0	0	4
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Vpr	4	0	0	4
muscleblind-like protein 1 isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	5	0	0	5
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transmembrane protease serine 2	0	1	2	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	12	0	0	12
Amyloid-beta precursor protein	3	1	0	4
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Integrin beta-3	5	2	1	8
Cytochrome P450 1A2	0	4	0	4
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	14	0	14
Integrin alpha-IIb	5	2	0	7
Ornithine decarboxylase	2	0	0	2
Fructose-1,6-bisphosphatase 1	0	1	0	1
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
D(2) dopamine receptor	0	9	1	12
Alpha-2B adrenergic receptor	0	6	0	6
D(1A) dopamine receptor	0	6	0	7
D(4) dopamine receptor	0	8	1	11
Sodium-dependent noradrenaline transporter	0	14	0	14
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	2	0	2
Mu-type opioid receptor	0	10	3	13
D(3) dopamine receptor	0	8	1	11
Alpha-synuclein	2	1	0	3
Kappa-type opioid receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	10	0	10
C-C chemokine receptor type 2	0	2	0	2
5-hydroxytryptamine receptor 6	0	5	0	6
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Sodium-dependent dopamine transporter	0	6	0	6
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Inositol hexakisphosphate kinase 1	8	0	0	8
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
cytochrome P450 2C9, partial	8	0	0	8
heat shock protein 90, putative	0	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Integrin alpha-V	0	0	1	1
Solute carrier family 22 member 1	0	5	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	5	0	5
Kappa-type opioid receptor	0	4	0	4
Histamine H1 receptor	0	3	0	3
Delta-type opioid receptor	0	5	0	5
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Sigma non-opioid intracellular receptor 1	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	4	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	6	0	0	6
Skn7p	0	0	0	1
67.9K protein	4	0	0	4
hemoglobin subunit beta	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	4	0	4
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
glucocerebrosidase	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Cytochrome P450 3A4	0	4	0	5
5-hydroxytryptamine receptor 1A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	3	0	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	4	0	4
Beta-2 adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M1	0	6	0	6
Cytochrome P450 2C9	0	5	0	5
Angiotensin-converting enzyme	0	5	0	5
Integrin alpha-4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Beta-1 adrenergic receptor	0	2	0	2
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	5	0	5
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	3	0	3
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	2
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Histamine H2 receptor	0	4	0	4
D(1B) dopamine receptor	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	8	0	8
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 1D	0	2	0	2
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
C-8 sterol isomerase	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Albumin	0	2	1	3
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
GALC protein	3	0	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chymotrypsinogen A	0	1	0	1
mitogen-activated protein kinase 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
Parkin	2	0	0	2
P53	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Estrogen receptor	0	8	1	10
Androgen receptor	0	9	0	9
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2B6	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
WRN	1	0	0	1
DNA polymerase III, partial	2	0	0	2
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
phospholipase A2, group III	0	1	0	1
interferon gamma precursor	0	0	0	2
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 3	0	2	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Tyrosine-protein kinase Fyn	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
DNA topoisomerase 2-alpha	0	1	0	2
DNA topoisomerase 2	0	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
DNA topoisomerase 2-beta	0	0	0	1
Tyrosine-protein kinase BTK	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Integrase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Estrogen receptor	0	0	2	3
Progesterone receptor	0	5	2	8
Estrogen receptor beta	0	0	2	3
5-hydroxytryptamine receptor 3E	0	1	1	3
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	1	3
5-hydroxytryptamine receptor 3C	0	1	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	1	3
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, CES1 protein	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Vesicular glutamate transporter 3	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Glossoptosis, Micrognathia, and Cleft Palate

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (184)

Protein Targets (736)

Glossoptosis, Micrognathia, and Cleft Palate

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (184)

Drugs Studied (87)

Protein Targets (736)