Glaucoma, Neovascular

A form of secondary glaucoma which develops as a consequence of another ocular disease and is attributed to the forming of new vessels in the angle of the anterior chamber.

Synonym
Glaucoma, Neovascular

Excerpt	Reference
"We conclude that neovascular glaucoma is more likely to occur in older subjects with CRVO."	( Dodson, PM; Keenan, JM; Kritzinger, EE, 1993)
"Neovascular glaucoma is a dreadful pathology with a rapid spontaneous evolution responsible for painful and blind eye."	( Baudouin, C; Hamard, P, 2000)
"Neovascular glaucoma is a devastating ocular disease that often results in loss of vision."	( Gass, JD; O'Day, DM; Sivak-Callcott, JA; Tsai, JC, 2001)
"Neovascular glaucoma is a frequent complication of vitrectomy performed to treat proliferative diabetic retinopathy (PDR)."	( Itakura, H; Kishi, S; Kotajima, N; Murakami, M, 2004)
"Neovascular glaucoma is a chronic and sight-threatening disease."	( Baudouin, C; Bellotti, A; El Mahtoufi, A; Fayol, N; Labbé, A, 2007)
"Neovascular glaucoma is a rare and severe complication of hypoperfusion retinopathy associated with either ipsilateral common carotid artery obstruction or severe bilateral obstruction of the internal carotid arteries."	( Wei, SH; Zhang, MN; Zhao, N; Zhou, BY, 2008)
"Neovascular glaucoma is defined as an iris and/or anterior chamber angle neovascularization associated with increased intraocular presure."	( Călugăru, D; Călugăru, M, 2012)
"Neovascular glaucoma is a serious complication associated with retinal ischemic changes, which increase the production of vascular endothelial growth factor."	( Ishibashi, S; Kondo, H, 2015)
"Neovascular glaucoma is an ophthalmic disease and a potentially blinding secondary glaucoma caused by the formation of abnormal new blood vessels on the iris, which can prevent the normal drainage of water from the anterior segment of the eye."	( Wei, HY; Zhang, YJ; Zhao, SZ, 2018)

Excerpt	Reference
"The efficacy of treating diabetic neovascular glaucoma by panretinal cryotherapy and trabeculectomy was studied over post-operative periods of 6-24 months in 26 selected eyes (8 acute cases and 18 chronic cases)."	( Castro, J; Cordido, M; Fernández-Sabugal, J; Fernández-Vigo, J, 1988)
"Bevacizumab, a drug widely used in the treatment of neovascular glaucoma neutralizes all isoforms of VEGF and ameliorates neovascularization after intracameral administration."	( Chalam, KV; Rusovici, R; Sakhalkar, M, 2011)
"The diagnosis and treatment of neovascular glaucoma in children is challenging and often a complication of a systemic or late-stage ocular condition."	( Nieves-Moreno, M; Noval, S; Peralta, J, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (2.79)	23.3326
1990's	52 (24.19)	12.5806
2000's	74 (34.42)	18.1394
2010's	68 (31.63)	28.8240
2020's	15 (6.98)	9.53

Drug	Relationship Strength	Studies	Trials
methane	low	1	0
lactic acid	low	1	0
urea	low	1	0
acetazolamide	low	3	0
aspirin	low	1	0
chlorpromazine	low	1	0
erythrosine	low	1	0
fluorouracil	medium	8	1
hydroxyurea	low	1	0
lidocaine	low	1	0
2-propanol	medium	101	6
mepivacaine	low	1	0
thalidomide	low	1	0
prednisolone	low	2	0
prednisone	low	1	0
pilocarpine	medium	1	1
perflutren	low	1	0
triamcinolone acetonide	medium	3	1
copper phthalocyanine	low	1	0
durapatite	low	1	0
vancomycin	low	1	0
fluorescein	low	1	0
palladium	low	1	0
helium	low	4	0
triamcinolone	medium	4	1
timolol	low	2	0
etoposide	low	3	0
propiconazole	low	3	0
brinzolamide	low	1	0
homocysteine	low	2	0
imatinib mesylate	low	1	0
methotrexate	low	1	0
carboplatin	low	3	0
fibrin	low	2	0
retinaldehyde	low	1	0
dermatan sulfate	low	1	0
cloprostenol	low	1	0
puerarin	low	1	0
losartan potassium	low	5	0
indocyanine green	low	4	0
oligonucleotides	medium	1	1
interleukin-8	low	2	0
heparitin sulfate	low	1	0
almagate	low	2	0
transforming growth factor beta	low	1	0
ganfort	low	1	0
chondroitin sulfates	low	1	0
trypan blue	low	1	0
eye	medium	31	1
2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester	low	1	0

Protein Targets (677)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	16	0	0	16
GLI family zinc finger 3	18	0	0	18
AR protein	24	0	0	24
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	15	0	0	15
estrogen nuclear receptor alpha	22	0	0	22
peroxisome proliferator-activated receptor delta	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	10	0	0	10
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
lamin isoform A-delta10	13	0	0	13
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Glutamate receptor 2	12	0	0	12
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	11	0	0	11
GALC protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
glucocorticoid receptor [Homo sapiens]	16	0	0	16
estrogen-related nuclear receptor alpha	20	0	0	20
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	7	0	0	7
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	8	0	0	8
geminin	11	0	0	11
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	7	1	1	9
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	3	1	7
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	16	0	16
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	11
Carbonic anhydrase 2	0	7	3	15
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	1	2
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	3	0	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	2
Cytochrome P450 2D6	0	3	1	4
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2C9	0	5	0	5
5-hydroxytryptamine receptor 2A	0	4	0	4
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	7	1	1	9
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	1	1	9
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	1	9
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	5	1	8
Carbonic anhydrase 6	0	3	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	7	1	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	1	9
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	1	9
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	1	9
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	1	9
Adenosine receptor A2a	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	4	1	8
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	3	1	6
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-3	7	1	1	9
Gamma-aminobutyric acid receptor subunit beta-2	7	1	1	9
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
GABA theta subunit	7	1	1	9
Canalicular multispecific organic anion transporter 1	0	14	0	15
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	1	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	6	0	0	6
cytochrome P450 2D6	12	0	0	12
glucocerebrosidase	1	0	0	1
Rac1 protein	0	0	1	1
IDH1	8	0	0	8
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
DNA polymerase kappa isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
pregnane X receptor	5	0	0	5
progesterone receptor	14	0	0	14
farnesoid X nuclear receptor	11	0	0	11
pregnane X nuclear receptor	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
aryl hydrocarbon receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
peroxisome proliferator activated receptor gamma	9	0	0	9
thyroid hormone receptor beta isoform 2	12	0	0	12
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
TDP1 protein	15	0	0	15
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
chromobox protein homolog 1	13	0	0	13
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acetylcholinesterase	10	0	0	10
phosphopantetheinyl transferase	6	0	0	6
estrogen receptor 2 (ER beta)	11	0	0	11
G	3	0	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
ATP-dependent phosphofructokinase	6	0	0	6
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	4	0	0	4
USP1 protein, partial	2	0	0	2
NFKB1 protein, partial	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
Thrombopoietin	2	0	0	2
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	5	0	0	5
NADPH oxidase 1	0	1	0	1
polyprotein	4	0	0	4
67.9K protein	5	0	0	5
Snq2p	0	0	0	1
caspase-3	5	0	0	5
Adenylate cyclase type 1	0	2	0	2
thyroid stimulating hormone receptor	6	0	0	6
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	2	0	0	2
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	4	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Bile salt export pump	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	2	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cellular tumor antigen p53	12	0	0	12
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	5
Muscarinic acetylcholine receptor M1	0	3	0	4
Muscarinic acetylcholine receptor M3	0	3	0	4
Muscarinic acetylcholine receptor M4	0	3	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M5	0	3	0	4
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	5	1	6
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	4
Muscarinic acetylcholine receptor M1	0	3	2	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	3
Alpha-1B adrenergic receptor	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Alpha-2C adrenergic receptor	0	4	1	5
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	8	1	9
Alpha-2B adrenergic receptor	0	5	0	5
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	5	0	5
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	5	0	5
Alpha-1D adrenergic receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	8	0	8
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
D(3) dopamine receptor	0	2	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	5
Histamine H2 receptor	4	0	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	6	1	1	8
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	10	0	0	10
Angiotensin-converting enzyme 2	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Ferritin light chain	5	0	0	5
Chain A, Cruzipain	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
regulator of G-protein signaling 4	3	0	0	3
Beta-1 adrenergic receptor	0	0	2	2
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
Alpha-1A adrenergic receptor	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Adenosine receptor A2b	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Inositol monophosphatase 1	2	0	0	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Nischarin	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostacyclin receptor	0	1	0	1
Prostaglandin D2 receptor	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Genome polyprotein	0	1	1	2
Luciferase	4	0	0	4
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
thioredoxin glutathione reductase	3	0	0	3
thyrotropin-releasing hormone receptor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
glp-1 receptor, partial	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
ATPase family AAA domain-containing protein 5	9	0	0	9
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
endonuclease IV	1	0	0	1
Skn7p	0	0	0	1
nonstructural protein 1	2	0	0	2
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	3	0	0	3
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
Beta-2 adrenergic receptor	0	4	0	4
Beta-1 adrenergic receptor	0	4	0	4
Beta-3 adrenergic receptor	0	4	0	4
Potassium channel subfamily K member 3	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase beta	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Aldo-keto reductase family 1 member B10	0	0	0	2
Aldo-keto reductase family 1 member B1	0	0	0	1
Alpha-synuclein	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Olfactory receptor 51E2	0	0	1	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (215)

Protein Targets (677)

Glaucoma, Neovascular

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (215)

Drugs Studied (64)

Protein Targets (677)