Gestational Luteoma

An ovarian neoplasm composed of LUTEAL CELLS derived from luteinized GRANULOSA CELLS and THECA CELLS. Luteomas respond to GONADOTROPINS, and vary in their hormone production (PROGESTERONE; ESTROGENS; or ANDROGENS). During PREGNANCY, a transient type of luteoma may develop due to an exaggerated LUTEINIZATION of the OVARY.

Synonym
Luteoma
Luteinoma
Gestational Luteoma
Pregnancy Luteoma
Luteoma of Pregnancy

Excerpt	Reference
"A stromal luteoma is an uncommon ovarian tumour in post-menopausal women, which presents rarely with hyperandrogenism and virilization."	( Calaf, J; Chico, A; García, JL; Matías-Guiu, X; Prat, J; Rodríguez, J; Webb, SM, 1995)
"Luteomas are usually asymptomatic tumour-like ovarian lesions of pregnancy that secrete androgens in only 25% of cases."	( Allen, L; Chitayat, D; Colgan, T; Dodge, JE; Salle, JL; Spitzer, RF; Wherrett, D, 2007)
"Of these, pregnancy luteoma is the most common cause of maternal virilization during pregnancy, and approximately 20 cases have been reported in recent years."	( Hasegawa, K; Inuzuka, H; Kato, R; Kuroda, M; Minami, Y; Oe, S; Tsukada, K; Udagawa, Y, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (21.74)	23.3326
1990's	5 (21.74)	12.5806
2000's	8 (34.78)	18.1394
2010's	3 (13.04)	28.8240
2020's	2 (8.70)	9.53

Drug	Relationship Strength	Studies
metyrapone	low	1
17-alpha-hydroxyprogesterone	low	1
reticulin	low	1
tetradecanoylphorbol acetate	low	1
buserelin	low	3
biotin	low	1
thapsigargin	low	1
leuprolide	low	1
enclomiphene	low	1
17-ketosteroids	low	1
pregnanediol	low	2
mart-1 antigen	low	1
aglepristone	low	1
cosyntropin	low	1
alfaprostol	low	1
cyclosporine	low	1

Protein Targets (199)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	1	0	0	1
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
TDP1 protein	2	0	0	2
GLI family zinc finger 3	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
AR protein	1	0	0	1
progesterone receptor	1	0	0	1
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
estrogen-related nuclear receptor alpha	2	0	0	2
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
estrogen nuclear receptor alpha	2	0	0	2
G	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
activating transcription factor 6	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
chromobox protein homolog 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
geminin	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	1	0	1
Androgen receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Glutamate receptor 2	1	0	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
TAR DNA-binding protein 43	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, Beta-lactamase	1	0	0	1
glp-1 receptor, partial	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
Smad3	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Epidermal growth factor receptor	0	1	0	1
Estrogen receptor	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
C-8 sterol isomerase	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
thioredoxin reductase	2	0	0	2
GALC protein	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Bile salt export pump	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	1	0	0	1
USP1 protein, partial	1	0	0	1
GLS protein	1	0	0	1
PPM1D protein	1	0	0	1
DNA polymerase III, partial	1	0	0	1
polyprotein	1	0	0	1
Parkin	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	1	2
D(1A) dopamine receptor	1	0	0	1
Ataxin-2	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Research

Studies (23)

Protein Targets (199)

Gestational Luteoma

Synonyms(5)

Research Excerpts

Overview

Research

Studies (23)

Drugs Studied (24)

Protein Targets (199)