Page last updated: 2024-09-27

Generalized Resistance to Thyroid Hormone

An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.

Synonyms(6)

Synonym
Thyroid Hormone Resistance
Generalized Thyroid Hormone Resistance
Generalized Resistance to Thyroid Hormone
Refetoff-DeWind-DeGroot Syndrome
Thyroid Hormone Resistance Syndrome
Refetoff Syndrome

Research Excerpts

Overview

ExcerptReference
"Thyroid hormone resistance syndromes are disorders in which there is decreased end-organ responsiveness to thyroid hormone."( Ahmet, A; Tsai, SL, 2012)
"Thyroid hormone resistance syndrome is characterized by a reduced target tissue response to the action of thyroid hormone, which leads to high levels of free thyroxine and free triiodothyronine with non-suppressed levels of thyrotropin (TSH)."( Antonia Pérez-Lázaro, M; Isabel del Olmo-García, M; León-de Zayas, B; Merino-Torres, JF; Moreno-Macián, F; Navas-de Solis, S; Ramos-Prol, A, 2013)

Research

Studies (181)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's46 (25.41)12.5806
2000's59 (32.60)18.1394
2010's53 (29.28)28.8240
2020's23 (12.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
cytosine0low10
glycine0low20
iodine0low40
amiodarone0low10
metformin0low10
methylphenidate0low10
mirtazapine0low10
3,3',5-triiodothyroacetic acid0low140
thyroxine0medium941
triiodothyronine0medium1184
alanine0low20
serine0medium41
lysine0low10
leucine0low40
methionine0low30
histidine0low20
valine0low20
threonine0low40
arginine0low40
dextrothyroxine0low30
thiazoles0low10
manganese0low10
technetium0low20
gadolinium0low10
tetradecanoylphorbol acetate0low10
paroxetine0low10
colforsin0low10
venlafaxine hydrochloride0low10
tetraiodothyroacetic acid0low10
homocysteine0low10
proline0medium21
3,3',5-triiodothyronamine0low10
5'-methylthioadenosine0low10
trichostatin a0low10
tretinoin0low10
isomethyleugenol0low10
propylthiouracil0low40
methimazole0low60
thyroxamine0low10
quinagolide0low10
phosphorus0low30
selenium0low20
fg-45920low10
mgl-31960low10
liraglutide0low10
sodium pertechnetate tc 99m0low10
quetiapine fumarate0low10
triiodothyronine, reverse0low30
muramidase0low10
guanine0low10
metallothionein0low10

Protein Targets (604)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
hypoxia-inducible factor 1 alpha subunit7007
SMAD family member 22002
USP1 protein, partial5005
SMAD family member 32002
AR protein110011
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
estrogen receptor 2 (ER beta)7007
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor8008
glucocorticoid receptor [Homo sapiens]9009
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor7007
estrogen nuclear receptor alpha150015
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma100010
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
euchromatic histone-lysine N-methyltransferase 2110011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
cytochrome P450 2C9 precursor4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA4004
thyroid hormone receptor beta isoform 2100010
heat shock protein beta-16006
DNA polymerase beta1001
nuclear factor erythroid 2-related factor 2 isoform 1110011
geminin100010
survival motor neuron protein isoform d5005
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta10100010
Cellular tumor antigen p53100010
Androgen receptor0202
Thyroid hormone receptor alpha04610
Thyroid hormone receptor beta04610
Proliferating cell nuclear antigen0303
Thyroid hormone receptor beta0404
Retinoic acid receptor RXR-alpha02810
Peroxisome proliferator-activated receptor gamma0088
Histamine H2 receptor4105
Sodium/bile acid cotransporter0101
Solute carrier organic anion transporter family member 1C10303
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
Protein arginine N-methyltransferase 50011
Indolethylamine N-methyltransferase0101
Adenosine receptor A30606
Catechol O-methyltransferase0101
Adenosine receptor A10203
Adenosine receptor A2a0001
Adenosine receptor A2b0102
Adenosine receptor A2a0102
Fatty acid synthase0202
S-methyl-5'-thioadenosine phosphorylase0001
Methylosome protein 500011
Spermidine synthase 0101
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma8008
TDP1 protein100010
cytochrome P450 family 3 subfamily A polypeptide 48008
pregnane X nuclear receptor130013
nuclear factor erythroid 2-related factor 2 isoform 23003
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump0808
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 24004
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Carbonic anhydrase 10003
Carbonic anhydrase 20003
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0416
Proton-coupled amino acid transporter 10506
Adenosine deaminase0001
Carbonic anhydrase 40002
acetylcholinesterase2002
phosphopantetheinyl transferase6006
ATAD5 protein, partial5005
Fumarate hydratase2002
NFKB1 protein, partial2002
PPM1D protein2002
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein6006
retinoic acid nuclear receptor alpha variant 18008
G6006
cytochrome P450 2D62002
polyprotein2002
caspase-31001
thyroid stimulating hormone receptor4004
Histone H2A.x3003
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a1001
D(1A) dopamine receptor3003
chromobox protein homolog 18008
thyroid hormone receptor beta isoform a5005
potassium voltage-gated channel subfamily H member 2 isoform d2002
huntingtin isoform 21001
mitogen-activated protein kinase 11001
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 14004
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 13003
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)4004
Gamma-aminobutyric acid receptor subunit pi3014
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier organic anion transporter family member 1A40204
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-31203
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10202
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10516
Integrin alpha-IIb1102
Beta-1 adrenergic receptor0404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0606
Cytochrome P450 2C80101
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0516
Androgen receptor0404
Gamma-aminobutyric acid receptor subunit beta-13014
Alpha-1B adrenergic receptor0707
Lethal factor0101
Alpha-2B adrenergic receptor0505
Gamma-aminobutyric acid receptor subunit delta3014
Gamma-aminobutyric acid receptor subunit gamma-23014
Gamma-aminobutyric acid receptor subunit alpha-53014
Gamma-aminobutyric acid receptor subunit alpha-33014
Muscarinic acetylcholine receptor M30404
ATP-dependent translocase ABCB10202
Substance-K receptor0202
D(1A) dopamine receptor0404
D(4) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit gamma-13014
Gamma-aminobutyric acid receptor subunit alpha-23014
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0718
Histamine H2 receptor0202
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0516
5-hydroxytryptamine receptor 2C0516
Gamma-aminobutyric acid receptor subunit alpha-43014
Gamma-aminobutyric acid receptor subunit gamma-33014
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-63014
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0718
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0505
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0303
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0606
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0707
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein4004
Gamma-aminobutyric acid receptor subunit alpha-13014
Gamma-aminobutyric acid receptor subunit beta-33014
Gamma-aminobutyric acid receptor subunit beta-23014
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0718
Potassium voltage-gated channel subfamily H member 20304
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit3014
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 16006
Canalicular multispecific organic anion transporter 10606
Sodium channel protein type 2 subunit alpha0101
Sigma non-opioid intracellular receptor 10505
Gamma-aminobutyric acid receptor subunit epsilon3014
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial6006
ATP-dependent phosphofructokinase5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase4004
GLS protein5005
alpha-galactosidase1001
cytochrome P450 2C19 precursor3003
DNA polymerase iota isoform a (long)1001
Cytochrome P450 3A40214
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
Genome polyprotein 0112
dopamine D1 receptor1001
regulator of G-protein signaling 43003
5-hydroxytryptamine receptor 1A0325
Alpha-2C adrenergic receptor0404
D0202
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 1B0303
D(4) dopamine receptor0101
Alpha-synuclein0202
D(2) dopamine receptor0213
glp-1 receptor, partial3003
pregnane X receptor2002
GLI family zinc finger 37007
aryl hydrocarbon receptor5005
nuclear receptor subfamily 1, group I, member 21001
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Nuclear receptor subfamily 1 group I member 20022
Rap guanine nucleotide exchange factor 32002
Solute carrier family 2, facilitated glucose transporter member 10011
Adenylate cyclase type 20011
Adenylate cyclase type 80011
Adenylate cyclase type 10112
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20011
IDH11001
Deoxycytidine kinase0001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Transthyretin0204
Prolyl 4-hydroxylase0202
Prolyl 3-hydroxylase OGFOD10101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Egl nine homolog 10112
Hypoxia-inducible factor 1-alpha inhibitor0101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Large neutral amino acids transporter small subunit 10505
Glutamate receptor ionotropic, NMDA 2D0214
Glutamate receptor ionotropic, NMDA 3B0214
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0214
Sodium- and chloride-dependent glycine transporter 20101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, HISTIDINE-BINDING PROTEIN0011
Carbonic anhydrase 120001
Plasma kallikrein0102
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Luciferase4004
activating transcription factor 64004
histone deacetylase 9 isoform 31001
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Phospholipase A-2-activating protein0101
Glucagon-like peptide 1 receptor0224
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Chain A, Ferritin light chain3003
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Multidrug and toxin extrusion protein 10101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Polyphenol oxidase 20203
Bile salt export pump0101
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Sodium-dependent dopamine transporter0404
Cytochrome P450 2C9 0213
Cytochrome P450 3A50101
Cytochrome P450 2C190213
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 2A0202
Alpha-1D adrenergic receptor0404
Sodium-dependent serotonin transporter0314
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
Type-2 angiotensin II receptor0101
Histamine H1 receptor0101
5-hydroxytryptamine receptor 3A0101
Angiotensin-converting enzyme0101
Transporter0404
NPC intracellular cholesterol transporter 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
M-phase phosphoprotein 82002
Sodium-dependent noradrenaline transporter0101
Myeloperoxidase0202
Quinolone resistance protein NorA0101
Cytochrome P450 2D60314
Angiotensin-converting enzyme0202
Aldo-keto reductase family 1 member B10101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Envelope glycoprotein0011
Rhodopsin kinase GRK10101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
P2X purinoceptor 40101
Beta-adrenergic receptor kinase 10001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
interleukin 81001
NADH-cytochrome b5 reductase 3 0101
Thyroid peroxidase0101
Taste receptor type 2 member 380012
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 4 0101
D0101
5-hydroxytryptamine receptor 3B0101
Chain A, 2-oxoglutarate Oxygenase2002
DNA polymerase kappa isoform 14004
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Cholinesterase0101
Microtubule-associated protein tau3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Luciferin 4-monooxygenase0011
Protein kinase C alpha type0112
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
thyrotropin-releasing hormone receptor2002
Integrin alpha-V 0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
apical membrane antigen 1, AMA12002
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A50002
UDP-glucuronosyltransferase 1A1 0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
Chain A, Nuclear Receptor ROR-beta0101
Chain A, Beta-lactamase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
thioredoxin glutathione reductase1001
nonstructural protein 11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
Caspase-71001
Bloom syndrome protein isoform 11001
caspase-31001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Cytochrome P450 1A20112
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Nuclear receptor ROR-gamma0112
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain A, Histone deacetylase 7a0101
Chain A, Histone deacetylase 7a0101
Histone deacetylase 80101
Histone deacetylase 0101
Lysine-specific demethylase 4E0101
glucocerebrosidase2002
unnamed protein product0001
Histone deacetylase 10202
Histone deacetylase 30204
5-hydroxytryptamine receptor 3A0101
Histone deacetylase 30101
Coagulation factor VII0101
Leukotriene A-4 hydrolase0101
Vitamin D3 receptor0101
Tissue factor0101
Adenosine receptor A10101
Histone deacetylase 40216
Histone deacetylase 20101
Histone deacetylase 10226
Splicing factor 3B subunit 30101
Histone deacetylase 10101
Adenosine receptor A10101
Histone deacetylase 0101
Histone deacetylase 40101
Polyamine deacetylase HDAC100101
Histone deacetylase 30101
Histone deacetylase-like amidohydrolase0202
Histone deacetylase 70101
NAD-dependent protein deacetylase sirtuin-60112
Histone deacetylase 80101
Histone deacetylase 70204
Histone deacetylase 110101
Histone deacetylase 20215
HD2 type histone deacetylase HDA106 0202
Polyamine deacetylase HDAC100204
Histone deacetylase 11 0204
Histone deacetylase 90101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
Histone deacetylase 80204
Histone deacetylase 60215
Histone deacetylase 90204
Histone deacetylase 50204
Histone deacetylase 0101
Nuclear receptor corepressor 20202
Histone deacetylase 60101
Histone deacetylase 50101
Histone deacetylase 0101
muscleblind-like protein 1 isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30101
Adenosine receptor A10202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1B30001
Gamma-aminobutyric acid receptor subunit theta0101
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]