ALDOB Deficiency

An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.

Synonym
Fructose-1,6-Bisphosphate Aldolase B Deficiency
Fructose-1,6-Biphosphate Aldolase Deficiency
Aldolase B Deficiency
ALDOB Deficiency
Fructose Aldolase B Deficiency
Fructose Intolerance
Fructose-1-Phosphate Aldolase Deficiency
Fructosemia
Hereditary Fructose Intolerance
Fructose Intolerance, Hereditary

Excerpt	Reference
"Undiscovered fructose intolerance is more likely the younger the patient is, whereas the frequency of glucose intolerance increases with age."	( Ahnefeld, FW; Bässler, KH; Grünert, A; Halmágyi, M; Mehnert, H; Schmitz, JE, 1987)
"Hereditary fructose intolerance is due to a deficiency of liver aldolase (aldolase B)."	( Delpech, M; Dreyfus, JC; Grégori, C; Kahn, A; Schapira, F, 1982)
"Fructose intolerance is more prevalent with fructose alone than with HFCS in health and in IBS."	( Bharucha, AE; Skoog, SM; Zinsmeister, AR, 2008)
"Fructose intolerance is another jigsaw piece of the IBS puzzle that may respond to dietary modification."	( Choi, YK; Jackson, M; Kraft, N; Rao, SS; Zimmerman, B, 2008)
"Hereditary fructose intolerance is a rare, but potentially lethal, inherited disorder of fructose metabolism, caused by mutation of the aldolase B gene."	( Bouteldja, N; Timson, DJ, 2010)

Excerpt	Reference
"Hereditary fructose intolerance (HFI) was diagnosed in a 61 year-old male patient on account of liver dysfunction followed by prolonged shock immediately after the administration of a fructose and lactose infusion postoperatively."	( Balogh, D; Decristoforo, A; Dworzak, E; Hackl, JM; Kunz, F; Maier, F; Puschendorf, B, 1978)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	105 (47.73)	23.3326
1990's	32 (14.55)	12.5806
2000's	30 (13.64)	18.1394
2010's	36 (16.36)	28.8240
2020's	17 (7.73)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	5	0
methane	low	2	0
3-hydroxybutyric acid	low	1	0
methylmalonic acid	low	1	0
lactic acid	low	3	0
dihydroxyacetone	low	1	0
glycerol	low	1	0
hydrogen carbonate	low	3	0
hydrogen	medium	10	3
kynurenine	low	1	0
pyridoxine	low	1	0
uric acid	medium	16	1
urea	low	2	0
mercaptoethanol	low	2	0
sorbitol	medium	27	1
glutamine	low	1	0
sucrose	low	9	0
adenosine diphosphate	low	1	0
galactose	low	10	0
edetic acid	low	1	0
tyrosine	low	10	0
adenosine monophosphate	low	1	0
leucine	low	1	0
lactose	low	10	0
methionine	low	1	0
tryptophan	medium	2	1
arginine	low	2	0
xylitol	low	1	0
glycidol	low	1	0
uridine diphosphate galactose	low	1	0
deuterium	low	1	0
fluorides	low	1	0
transferrin	low	7	0
fructose-1-phosphate	medium	8	1
deoxyglucose	low	1	0
proline	low	1	0
hawkinsin	low	1	0
glycogen	low	3	0
fructans	low	1	0
D-fructopyranose	medium	148	8
cystine	low	1	0
vitamin k semiquinone radical	low	1	0
cytochalasin b	low	1	0
phosphorus	medium	6	1
phosphocreatine	medium	1	1
nad	low	1	0
glucagon	low	3	0
oligonucleotides	low	1	0
cellulose	low	1	0
invert sugar	low	1	0
fructose-1,6-diphosphate	low	1	0
ascorbic acid	low	2	0
vitamin b 12	low	2	0
technetium tc 99m dimercaptosuccinic acid	low	1	0
sapropterin	low	1	0
folic acid	low	2	0

Protein Targets (409)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	2	0	0	2
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	2	2	4
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	2	2
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	2	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
RAR-related orphan receptor gamma	6	0	0	6
AR protein	8	0	0	8
glucocorticoid receptor [Homo sapiens]	4	0	0	4
estrogen-related nuclear receptor alpha	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	0	1	1
Adenylate kinase isoenzyme 1	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	3	0	0	3
NFKB1 protein, partial	1	0	0	1
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
chromobox protein homolog 1	7	0	0	7
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	5	0	0	5
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	0	0	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	1	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	2	0	0	2
GLI family zinc finger 3	6	0	0	6
thioredoxin glutathione reductase	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
estrogen nuclear receptor alpha	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
thyroid hormone receptor beta isoform 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	5	0	0	5
lamin isoform A-delta10	7	0	0	7
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	2	0	0	2
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
glp-1 receptor, partial	2	0	0	2
TDP1 protein	1	0	0	1
Smad3	1	0	0	1
PINK1	1	0	0	1
67.9K protein	1	0	0	1
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	1	0	0	1
Histone H2A.x	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Glutamate receptor 2	3	0	0	3
Histamine H2 receptor	1	0	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Carbonic anhydrase 1	0	2	0	5
Carbonic anhydrase 2	0	3	1	7
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 15	0	2	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Ferritin light chain	3	0	0	3
acid sphingomyelinase	1	0	0	1
USP1 protein, partial	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
retinoid X nuclear receptor alpha	5	0	0	5
glucocerebrosidase	1	0	0	1
activating transcription factor 6	4	0	0	4
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase beta	1	0	0	1
Multidrug resistance-associated protein 4	0	0	0	1
Bile salt export pump	0	3	0	3
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
arylsulfatase A	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
peroxisome proliferator-activated receptor delta	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
interleukin 8	1	0	0	1
Chain A, Cruzipain	1	0	0	1
Albumin	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Microtubule-associated protein tau	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
cytochrome P450 2D6	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	4	0	4
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Serine racemase	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Pyridoxal kinase	0	0	0	1
Bile salt export pump	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
pregnane X nuclear receptor	2	0	0	2
peripheral myelin protein 22	2	0	0	2
Carbonic anhydrase 9	0	1	1	4
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
GABA theta subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Carbonic anhydrase 12	0	0	0	2
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	2
Myeloperoxidase	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 6	0	0	0	2
Substance-P receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Carbonic anhydrase 7	0	0	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	2
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Beta-1,4-galactosyltransferase 1	0	0	0	1
N-acetyllactosaminide alpha-1,3-galactosyltransferase	0	0	0	1
P2Y purinoceptor 14	0	0	1	1
vitamin D3 receptor isoform VDRA	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (220)

Protein Targets (409)

ALDOB Deficiency

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (220)

Drugs Studied (72)

Protein Targets (409)