Page last updated: 2024-09-28

Fox-Fordyce Disease

Chronic pruritic disease, usually in women, characterized by small follicular papular eruptions in APOCRINE GLANDS areas. It is caused by obstruction and rupture of intraepidermal apocrine ducts.

Synonyms(3)

Synonym
Miliaria, Apocrine
Fox-Fordyce Disease
Fox-Fordyce Syndrome

Research

Studies (28)

TimeframeStudies, This Condition (%)All Conditions %
pre-199014 (50.00)23.3326
1990's6 (21.43)12.5806
2000's2 (7.14)18.1394
2010's5 (17.86)28.8240
2020's1 (3.57)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0low10
propylene glycol0low10
1-propanol0low10
hexachlorophene0low10
khellin0low10
loratadine0low10
fluocinolone acetonide0low10
norethindrone0low10
norethynodrel0low10
mestranol0low20
benzoyl peroxide0low10
chlormadinone acetate0low10
betamethasone0low10
carmine0low10
erbium0low10
triamcinolone0low10
fluocinolone0low10
pregnanetriol0low10
inositol 3-phosphate0low10
tretinoin0low50
tacrolimus0low30
clindamycin0low20
calcitriol0low10
isotretinoin0low20
phenylephrine hydrochloride0low10
desonide0low10
calcipotriene0low10

Protein Targets (399)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma110011
USP1 protein, partial8008
AR protein150015
nuclear receptor subfamily 1, group I, member 3100010
EWS/FLI fusion protein2002
glucocorticoid receptor [Homo sapiens]150015
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha140014
farnesoid X nuclear receptor8008
estrogen nuclear receptor alpha170017
peroxisome proliferator-activated receptor delta8008
peroxisome proliferator activated receptor gamma9009
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 67007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
Histone H2A.x5005
Bloom syndrome protein isoform 17007
thyroid hormone receptor beta isoform 2100010
heat shock protein beta-16006
nuclear factor erythroid 2-related factor 2 isoform 1120012
nuclear receptor ROR-gamma isoform 18008
geminin130013
peripheral myelin protein 22100010
lamin isoform A-delta108008
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Voltage-dependent calcium channel gamma-2 subunit9009
Bile salt export pump0808
Cellular tumor antigen p53110011
60 kDa chaperonin0303
Retinoic acid receptor alpha0339
60 kDa heat shock protein, mitochondrial0303
Retinoic acid receptor beta0339
Retinoic acid receptor gamma 0339
Aspartate aminotransferase, cytoplasmic0101
Glutamate receptor 2100010
Glycine receptor subunit alpha-10011
Spike glycoprotein6006
10 kDa heat shock protein, mitochondrial0303
Thiosulfate sulfurtransferase0303
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Canalicular multispecific organic anion transporter 10707
ATP-dependent phosphofructokinase2002
acetylcholinesterase5005
thyroid hormone receptor beta isoform a7007
pregnane X receptor3003
GLI family zinc finger 3120012
progesterone receptor100010
cytochrome P450 family 3 subfamily A polypeptide 4100010
pregnane X nuclear receptor120012
IDH14004
aryl hydrocarbon receptor4004
nuclear receptor subfamily 1, group I, member 25005
nuclear factor erythroid 2-related factor 2 isoform 25005
galanin receptor type 30101
Glucocorticoid receptor010010
Glycine receptor subunit alpha-1010010
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
ORF730011
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase3003
Chain A, Ferritin light chain6006
Vitamin D3 receptor0011
PPM1D protein1001
Microtubule-associated protein tau7007
thioredoxin glutathione reductase4004
euchromatic histone-lysine N-methyltransferase 29009
mitogen-activated protein kinase 16006
Interferon beta9009
Vitamin D-binding protein0011
Cytochrome P450 1A20315
Cytochrome P450 3A40416
Androgen receptor0101
Cytochrome P450 2D60213
Vitamin D3 receptor0124
Cytochrome P450 2C9 0315
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0235
Cytochrome P450 2C190516
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Luciferase5005
interleukin 81001
thioredoxin reductase6006
phosphopantetheinyl transferase2002
GLS protein3003
TDP1 protein150015
aldehyde dehydrogenase 1 family, member A15005
67.9K protein3003
luciferase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
potassium voltage-gated channel subfamily H member 2 isoform d3003
flap endonuclease 12002
eyes absent homolog 2 isoform a1001
DNA polymerase iota isoform a (long)5005
DNA polymerase kappa isoform 13003
survival motor neuron protein isoform d7007
cytochrome P450 3A4 isoform 16006
histone acetyltransferase KAT2A isoform 15005
Gamma-aminobutyric acid receptor subunit pi6006
Gamma-aminobutyric acid receptor subunit beta-16006
Tyrosine-protein phosphatase non-receptor type 10101
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Tyrosine-protein phosphatase 10101
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Alpha-synuclein2103
Nuclear receptor ROR-gamma3115
Gamma-aminobutyric acid receptor subunit alpha-16006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
Inositol monophosphatase 13003
C-terminal-binding protein 11001
GABA theta subunit6006
Gamma-aminobutyric acid receptor subunit epsilon6006
Chain A, Cruzipain5005
SMAD family member 27007
ATAD5 protein, partial5005
SMAD family member 37007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
retinoid X nuclear receptor alpha7007
G7007
bromodomain adjacent to zinc finger domain 2B5005
thyroid stimulating hormone receptor9009
v-jun sarcoma virus 17 oncogene homolog (avian)5005
vitamin D3 receptor isoform VDRA5005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 12002
snurportin-12002
neuropeptide S receptor isoform A2002
HLA class I histocompatibility antigen, B alpha chain 7007
Androgen receptor0909
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Protein-arginine deiminase type-40101
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Smad33003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
calpain II, partial0101
PAX80001
glp-1 receptor, partial5005
SUMO-10101
15-lipoxygenase, partial2002
Mcl-10101
Valosin-containing protein0101
TSHR protein1001
Estrogen receptor 10101
PINK11001
thyroid stimulating hormone receptor2002
envelope glycoprotein0101
estrogen receptor 2 (ER beta)6006
nonstructural protein 13003
cytochrome P450 2D65005
Parkin3003
heat shock protein 900011
heat shock 70kDa protein 1A0101
thyrotropin-releasing hormone receptor2002
Caspase-73003
galactokinase1001
NPC intracellular cholesterol transporter 1 precursor2002
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
neuropeptide Y receptor type 10011
neuropeptide Y receptor type 20011
small ubiquitin-related modifier 2 isoform b precursor0101
caspase-33003
estrogen receptor beta isoform 10101
huntingtin isoform 21001
DNA polymerase beta1001
enteropeptidase precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
fatty acid synthase0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK12002
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase eta isoform 12002
heat shock cognate 71 kDa protein isoform 10101
eukaryotic translation initiation factor 4E isoform 10101
Vpr2002
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase1001
replicative DNA helicase0001
recombinase A0011
streptokinase A precursor0011
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
POsterior Segregation0011
lethal factor (plasmid)1001
heat shock cognate 71 kDa protein isoform 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
5-hydroxytryptamine receptor 40202
Rap guanine nucleotide exchange factor 31001
Epidermal growth factor receptor0101
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Receptor tyrosine-protein kinase erbB-20101
Plasminogen activator inhibitor 10101
Estrogen receptor0022
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Urokinase-type plasminogen activator0101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M40112
Muscarinic acetylcholine receptor M50112
Alpha-2A adrenergic receptor0202
Replicase polyprotein 1a0101
Replicase polyprotein 1ab0101
Adenosine receptor A30606
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M20112
Endoplasmic reticulum chaperone BiP0101
Macrophage migration inhibitory factor0202
Alpha-1B adrenergic receptor0606
Alpha-2C adrenergic receptor0202
Substance-K receptor0202
Acetylcholinesterase0101
Sodium-dependent noradrenaline transporter 0213
Thromboxane-A synthase 0101
Adenosine receptor A11001
Mitogen-activated protein kinase 3 0101
5-hydroxytryptamine receptor 2C0202
Mitogen-activated protein kinase 10303
Adenosine receptor A2a0202
Sodium-dependent serotonin transporter0606
Prostaglandin G/H synthase 20101
5-hydroxytryptamine receptor 2B0808
Alpha-1A adrenergic receptor0606
Histamine H2 receptor2002
Caspase-71001
TAR DNA-binding protein 431001
Mitogen-activated protein kinase 140202
Estrogen receptor beta0022
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
Rap guanine nucleotide exchange factor 42002
Zinc finger protein mex-50011
phosphoglycerate kinase1001
heat shock protein 90, putative0001
M1-family alanyl aminopeptidase0101
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
BZLF20101
large T antigen0101
histone deacetylase 9 isoform 31001
regulator of G-protein signaling 42002
peripheral myelin protein 22 isoform 13003
serine/threonine-protein kinase mTOR isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Alpha-2B adrenergic receptor0202
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10203
Cellular retinoic acid-binding protein 10022
Olfactory receptor 51E20101
GALC protein2002
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor2002
GTP-binding nuclear protein Ran isoform 11001
Cytochrome P450 1A10202
Cytochrome P450 1B10101
Fumarate hydratase1001
Thrombopoietin1001
isocitrate dehydrogenase 1, partial1001
polyprotein1001
arylsulfatase A2002
alpha-galactosidase1001
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 16006
ras-related protein Rab-9A1001
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M11001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Nuclear receptor subfamily 1 group I member 20022
Integrin beta-31001
ATP-dependent translocase ABCB10101
Integrin alpha-IIb1001
Angiotensin-converting enzyme0202
Platelet-activating factor receptor0101
Histamine H1 receptor0213
Guanine nucleotide-binding protein G1001
Disintegrin and metalloproteinase domain-containing protein 171001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Nuclear receptor subfamily 3 group C member 3 0202
Bile acid receptor0101
Sodium-dependent neutral amino acid transporter B(0)AT20101
Histamine H4 receptor0101
Potassium channel subfamily K member 90101
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Estrogen receptor0404
Aldo-keto reductase family 1 member B10202
Cannabinoid receptor 10202
Sex hormone-binding globulin0011
Progesterone receptor0224
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 1 0202
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0203
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Muscarinic acetylcholine receptor M50012
Sigma non-opioid intracellular receptor 10101
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0202
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10101
Chain A, Nuclear Receptor ROR-beta0101
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 1A0101
Alpha-1D adrenergic receptor0101
Retinoic acid receptor RXR-beta0224
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Retinoic acid receptor RXR-gamma0224
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
NFKB1 protein, partial1001
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
Cytochrome P450 2J20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]