Fisher Syndrome

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

Synonym
Guillain-Barre Syndrome, Miller Fisher Variant
Guillain Barre Syndrome, Miller Fisher Variant
Miller Fisher Syndrome
Ophthalmoplegia, Ataxia and Areflexia Syndrome
Miller Fisher Variant of Guillain Barre Syndrome
Fisher Syndrome
Miller-Fisher Syndrome

Excerpt	Reference
"Miller-Fisher syndrome is defined by the triad: ophthalmoplegia, ataxia and areflexia."	( Bourrat, C; Caudie, C; Riche, G; Vial, C, 1998)
"Miller-Fisher syndrome is an autoimmune neuropathy characterized by ataxia, areflexia and ophthalmoplegia, and in the majority of cases the presence of high titres of anti-GQ1b ganglioside antibodies."	( Chakrabarti, M; Conner, J; Goodyear, CS; Molenaar, PC; Morrison, I; O'Hanlon, GM; Plomp, JJ; Rowan, EG; Stewart, S; Trapp, BD; Wagner, ER; Willison, HJ; Yin, X, 2001)
"Miller Fisher syndrome is characterized by a triad of ataxia, ophthalmoplegia, and reduced or absent tendon reflexes, with minimal if any limb weakness."	( Büyükavci, M; Caner, I; Deniz, O; Tan, H, 2003)
"Miller-Fisher syndrome is characterised by the clinical triad of ophthalmoplegia, ataxia and areflexia and is considered a variant form of Guillain-Barré syndrome."	( Jørgensen, L; Vedeler, CA, 2005)
"Miller Fisher syndrome is an autoimmune neuropathy characterised by ataxia, areflexia and ophthalmoplegia, with minimal if any limb weakness, and in the majority of cases by high titres of IgG anti-GQ1b ganglioside antibodies."	( Borghetti, D; Cafforio, G; Domenici, L; Murri, L; Orlandi, G; Sartucci, F, 2005)
"Miller Fisher syndrome is a localized variant of Guillain-Barré syndrome, characterized by ophthalmoplegia, areflexia and ataxia."	( Overell, JR; Willison, HJ, 2005)
"Miller Fisher Syndrome is an unusual condition seen in ophthalmologic clinical practice."	( Blanco-Marchite, CI; Buznego-Suárez, L; Fagúndez-Vargas, MA; Méndez-Llatas, M; Pozo-Martos, P, 2008)
"Fisher syndrome is a subtype of Guillain-Barré syndrome that is characterized by the three chief symptoms of acute-onset external ophthalmoplegia, ataxia, and loss of tendon reflexes."	( Funakoshi, K; Inoue, H; Ishida, H; Kokan, N; Nibu, K, 2008)
"Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia."	( Lee, KY, 2012)
"Miller-Fisher syndrome is defined as ophthalmoplegia, ataxia and areflexia."	( Agard, E; Camarasa, C; Dot, C; Drouet, A; Guilloton, L; Tondeur, G, 2014)
"Miller Fisher syndrome is defined by a triad of symptoms, namely areflexia, ataxia, and ophthalmoparesis."	( Ehler, E; Latta, J, 2014)
"Miller Fisher syndrome is a variant of Guillain-Barré syndrome caused by autoimmune antibodies specific for epitopes of peripheral axon terminals."	( Bergamin, E; Jalink, K; Montecucco, C; Negro, S; Rigoni, M; Rodella, U; Scorzeto, M; Yuki, N, 2017)

Excerpt	Reference
"Fisher syndrome has been regarded peculiar inflammatory neuropathy with ophthalmoplegia, ataxia, and areflexia, whereas Bickerstaff brainstem encephalitis has been considered pure central nervous system disease characterized with ophthalmoplegia, ataxia, and consciousness disturbance."	( Kuwabara, S, 2013)
"Fisher syndrome has been regarded as a peculiar inflammatory neuropathy with ophthalmoplegia, ataxia, and areflexia, whereas Bickerstaff brainstem encephalitis has been considered a pure central nervous system disease characterized by ophthalmoplegia, ataxia, and consciousness disturbance."	( Kuwabara, S, 2015)
"The Miller-Fisher syndrome has a prevalence of 0."	( Almonacid García, EY; Amadi, MA; Brogiolo, O; Goldaracena, PX; Orlandi, M; Pérez, FE, 2020)

Excerpt	Reference
"Three patients with Fisher syndrome and with a high serum IgG anti-GQ1b antibody titer underwent four to nine sessions of immunoadsorption therapy with a tryptophan-immobilized column."	( Nakamura, Y; Ohtsuka, K; Tagawa, Y; Yuki, N, 1998)
"Treatment for Miller Fisher syndrome (MFS) is controversial, and even the natural history and prognosis are not fully understood."	( Fukudome, T; Goto, H; Kambara, C; Matsuo, H; Shibuya, N, 2002)
"He was diagnosed with Fisher syndrome and given intravenous immunoglobulin therapy from day 6 to day 10 after disease onset."	( Hirose, B; Shimizu, M; Shimohama, S; Suzuki, S; Yamada, M; Yamamoto, D, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	34 (14.41)	12.5806
2000's	102 (43.22)	18.1394
2010's	80 (33.90)	28.8240
2020's	20 (8.47)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	1
salicylic acid	low	1
thiamine	low	1
azathioprine	low	1
baclofen	low	1
diazepam	low	1
diclofenac	low	1
edrophonium	low	1
gabapentin	low	1
hydroxychloroquine	low	1
propofol	low	1
prednisolone	low	2
prednisone	low	1
tryptophan	low	3
methylprednisolone	low	6
stavudine	low	1
gadolinium	low	3
diltiazem	low	1
atracurium	low	1
fomesafen	low	2
remifentanil	low	1
valsartan	low	1
cisatracurium	low	1
phosphoramidic acid	low	1
fluorodeoxyglucose f18	low	2
calpeptin	low	1
bendamustine hydrochloride	low	1
methotrexate	low	1
carbapenems	low	1
retinol	low	1
tacrolimus	low	1
methylproamine	low	1
bromochloroacetic acid	low	1
rutin	low	1
ganglioside, gd1b	low	8
trisialoganglioside gt1	low	6
ganglioside, gd2	low	1
asialo gm1 ganglioside	low	2
gadolinium dtpa	low	3
g(m1) ganglioside	low	29
pituitrin	low	1
ganglioside, gd1a	low	1
glycolipids	low	8
piperidines	low	1
interleukin-8	low	1
g(m3) ganglioside	low	1
gq1b ganglioside	low	1
cyclosporine	low	1
exudates	low	2
acyclovir	low	1
eye	low	3
concanavalin a	low	1
gq1b ganglioside	medium	170

Protein Targets (573)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	6	0	0	6
Thymidine kinase	0	1	0	1
thioredoxin reductase	10	0	0	10
phosphopantetheinyl transferase	6	0	0	6
GLS protein	4	0	0	4
TDP1 protein	10	0	0	10
Smad3	2	0	0	2
thyroid stimulating hormone receptor	8	0	0	8
EWS/FLI fusion protein	6	0	0	6
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
activating transcription factor 6	4	0	0	4
Histone H2A.x	7	0	0	7
Bloom syndrome protein isoform 1	9	0	0	9
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	11	0	0	11
Solute carrier family 22 member 1	0	2	0	4
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	12
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	4	0	4
Bile salt export pump	0	14	0	14
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	4	0	5
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	10	0	10
Thymidine kinase	0	1	0	1
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
interleukin 8	3	0	0	3
acetylcholinesterase	4	0	0	4
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	1	0	0	1
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	10	0	0	10
Microtubule-associated protein tau	6	0	0	6
AR protein	10	0	0	10
thioredoxin glutathione reductase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
glucocorticoid receptor [Homo sapiens]	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	13	0	0	13
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	14	0	0	14
G	5	0	0	5
polyprotein	1	0	0	1
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	7	0	0	7
IDH1	3	0	0	3
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
thyroid hormone receptor beta isoform 2	8	0	0	8
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
DNA polymerase iota isoform a (long)	5	0	0	5
geminin	8	0	0	8
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	5	2	12
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Cellular tumor antigen p53	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-1	5	5	2	12
Gamma-aminobutyric acid receptor subunit delta	5	5	2	12
Gamma-aminobutyric acid receptor subunit gamma-2	5	5	4	14
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	5	2	12
Gamma-aminobutyric acid receptor subunit alpha-3	5	5	2	12
Gamma-aminobutyric acid receptor subunit gamma-1	5	5	2	12
Gamma-aminobutyric acid receptor subunit alpha-2	5	5	2	12
Gamma-aminobutyric acid receptor subunit alpha-4	5	5	2	12
Gamma-aminobutyric acid receptor subunit gamma-3	5	5	2	12
Gamma-aminobutyric acid receptor subunit alpha-6	5	5	2	12
Nuclear receptor ROR-gamma	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	5	5	4	14
Gamma-aminobutyric acid receptor subunit beta-3	5	5	2	12
Gamma-aminobutyric acid receptor subunit beta-2	5	5	4	14
GABA theta subunit	5	5	2	12
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	5	5	2	12
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	5	0	0	5
NFKB1 protein, partial	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	2	0	0	2
D(1A) dopamine receptor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
ATP-dependent phosphofructokinase	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
PPM1D protein	2	0	0	2
vitamin D3 receptor isoform VDRA	4	0	0	4
Calpain-9	0	1	0	1
Calpain-1 catalytic subunit	0	2	0	2
Procathepsin L	0	1	1	2
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Cathepsin K	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	1	0	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Fatty acid-binding protein, liver	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	3	6
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	4	8
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
5-hydroxytryptamine receptor 1A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	3	7
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	4	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	5	0	6
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	1	7
Transthyretin	0	0	1	3
Prostaglandin G/H synthase 1	0	1	0	1
Cytochrome P450 3A4	0	5	0	6
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
cytochrome P450 2D6	2	0	0	2
glucocerebrosidase	1	0	0	1
huntingtin isoform 2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Spike glycoprotein	4	0	1	5
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
dopamine D1 receptor	2	0	0	2
Cholinesterase	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	3
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	5	0	0	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Genome polyprotein	0	2	0	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
chromobox protein homolog 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	3	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
flap endonuclease 1	3	0	0	3
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
nonstructural protein 1	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Alpha-synuclein	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Neuraminidase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Polyphenol oxidase 2	0	2	0	3
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Substance-P receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	2
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	2	0	3
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
endonuclease IV	1	0	0	1
Thymidine kinase 2	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Reverse transcriptase/RNaseH	0	1	1	3
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Thromboxane A2 receptor	0	0	0	1
Type-1A angiotensin II receptor	0	1	1	2
Type-1B angiotensin II receptor	0	1	0	1
Type-1 angiotensin II receptor	0	2	1	4
Type-1 angiotensin II receptor	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
Leukotriene B4 receptor 2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Protein Targets (573)

Fisher Syndrome

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Drugs Studied (65)

Protein Targets (573)