| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| Adenosylhomocysteinase | 0 | 2 | 0 | 5 |
| Histone-lysine N-methyltransferase EZH2 | 0 | 1 | 0 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 3 | 0 | 0 | 3 |
| Chain A, MTA/SAH nucleosidase | 0 | 1 | 0 | 1 |
| Chain A, Ribosome-inactivating protein alpha-trichosanthin | 0 | 0 | 1 | 1 |
| Chain A, Ricin A chain | 0 | 0 | 1 | 1 |
| Chain A, Ribosome-inactivating protein 3 | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Phenylethanolamine N-methyltransferase | 0 | 0 | 1 | 1 |
| RAR-related orphan receptor gamma | 2 | 0 | 0 | 2 |
| TDP1 protein | 3 | 0 | 0 | 3 |
| AR protein | 3 | 0 | 0 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | 2 | 0 | 0 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | 2 | 0 | 0 | 2 |
| glucocorticoid receptor [Homo sapiens] | 2 | 0 | 0 | 2 |
| estrogen-related nuclear receptor alpha | 3 | 0 | 0 | 3 |
| pregnane X nuclear receptor | 2 | 0 | 0 | 2 |
| estrogen nuclear receptor alpha | 4 | 0 | 0 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 2 | 0 | 0 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | 2 | 0 | 0 | 2 |
| heat shock protein beta-1 | 1 | 0 | 0 | 1 |
| importin subunit beta-1 isoform 1 | 1 | 0 | 0 | 1 |
| snurportin-1 | 1 | 0 | 0 | 1 |
| tumor susceptibility gene 101 protein | 1 | 0 | 0 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 3 | 0 | 0 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | 3 | 0 | 0 | 3 |
| Bile salt export pump | 0 | 4 | 0 | 4 |
| Cyclin-dependent kinase 1 | 0 | 1 | 0 | 1 |
| Heat shock protein HSP 90-beta | 0 | 1 | 0 | 1 |
| Glutamate receptor 2 | 3 | 0 | 0 | 3 |
| Xanthine dehydrogenase/oxidase | 0 | 1 | 0 | 1 |
| TAR DNA-binding protein 43 | 1 | 0 | 0 | 1 |
| Protein mono-ADP-ribosyltransferase PARP15 | 0 | 1 | 0 | 1 |
| Leucine-rich repeat serine/threonine-protein kinase 2 | 0 | 2 | 0 | 2 |
| ATPase family AAA domain-containing protein 5 | 1 | 0 | 0 | 1 |
| Ataxin-2 | 3 | 0 | 0 | 3 |
| Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
| Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
| Chain A, Membrane lipoprotein tmpC | 0 | 0 | 1 | 1 |
| Chain A, Structure of PAE2307 in complex with adenosine | 0 | 0 | 1 | 1 |
| Chain B, Structure of PAE2307 in complex with adenosine | 0 | 0 | 1 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | 0 | 1 | 0 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | 0 | 1 | 0 | 1 |
| Chain A, tRNA (guanine-N(1)-)-methyltransferase | 0 | 0 | 1 | 1 |
| Chain A, Uncharacterized protein MJ0883 | 0 | 0 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | 1 | 0 | 0 | 1 |
| regulator of G-protein signaling 4 | 2 | 0 | 0 | 2 |
| retinoid X nuclear receptor alpha | 1 | 0 | 0 | 1 |
| NPYLR7B | 0 | 0 | 1 | 1 |
| arylsulfatase A | 3 | 0 | 0 | 3 |
| IDH1 | 1 | 0 | 0 | 1 |
| Histone H2A.x | 2 | 0 | 0 | 2 |
| glycogen synthase kinase-3 beta isoform 1 | 0 | 0 | 2 | 2 |
| mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
| flap endonuclease 1 | 2 | 0 | 0 | 2 |
| nuclear receptor ROR-gamma isoform 1 | 1 | 0 | 0 | 1 |
| peripheral myelin protein 22 | 1 | 0 | 0 | 1 |
| survival motor neuron protein isoform d | 3 | 0 | 0 | 3 |
| high affinity choline transporter 1 isoform a | 0 | 1 | 0 | 1 |
| Sodium/nucleoside cotransporter 1 | 0 | 2 | 0 | 2 |
| Calcium dependent protein kinase | 0 | 1 | 0 | 1 |
| Mitogen-activated protein kinase kinase kinase 7 | 0 | 0 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | 0 | 2 | 0 | 2 |
| Rap guanine nucleotide exchange factor 3 | 2 | 0 | 0 | 2 |
| Purine nucleoside phosphorylase | 0 | 2 | 0 | 2 |
| Epidermal growth factor receptor | 0 | 1 | 0 | 1 |
| Phosphoglycerate kinase 1 | 0 | 1 | 0 | 1 |
| Adenosine deaminase | 0 | 0 | 0 | 1 |
| Avidin | 0 | 0 | 1 | 1 |
| Adenosine deaminase | 0 | 0 | 0 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | 0 | 2 | 0 | 2 |
| Receptor tyrosine-protein kinase erbB-2 | 0 | 1 | 0 | 1 |
| Insulin receptor | 0 | 0 | 0 | 1 |
| Phosphoglycerate kinase 2 | 0 | 1 | 0 | 1 |
| Heat shock protein HSP 90-alpha | 0 | 1 | 1 | 2 |
| Platelet-derived growth factor receptor beta | 0 | 0 | 0 | 1 |
| Adenosine receptor A3 | 0 | 3 | 2 | 6 |
| Heat shock 70 kDa protein 1A | 0 | 1 | 0 | 1 |
| Heat shock cognate 71 kDa protein | 0 | 0 | 1 | 1 |
| Fibroblast growth factor receptor 1 | 0 | 0 | 0 | 1 |
| Inosine-5'-monophosphate dehydrogenase 2 | 0 | 1 | 0 | 1 |
| Endoplasmin | 0 | 1 | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase 1 | 0 | 1 | 0 | 1 |
| Fibroblast growth factor receptor 2 | 0 | 0 | 0 | 1 |
| Fibroblast growth factor receptor 4 | 0 | 0 | 0 | 1 |
| Fibroblast growth factor receptor 3 | 0 | 0 | 0 | 1 |
| Streptavidin | 0 | 0 | 1 | 1 |
| Adenosine receptor A1 | 0 | 1 | 1 | 2 |
| Adenosine receptor A3 | 0 | 1 | 0 | 1 |
| Adenosine receptor A2a | 0 | 2 | 2 | 5 |
| Adenosine receptor A2b | 0 | 1 | 1 | 3 |
| Adenosine receptor A2b | 0 | 1 | 1 | 2 |
| Adenylate kinase 2, mitochondrial | 0 | 1 | 0 | 1 |
| Adenosine receptor A1 | 0 | 3 | 2 | 6 |
| Adenosine receptor A2a | 0 | 1 | 1 | 2 |
| Adenylate kinase isoenzyme 1 | 0 | 1 | 0 | 1 |
| Phosphatidylinositol 4-kinase alpha | 0 | 2 | 0 | 3 |
| Adenosine receptor A1 | 0 | 0 | 1 | 1 |
| Adenosine kinase | 0 | 0 | 0 | 1 |
| Adenosine deaminase | 0 | 0 | 0 | 1 |
| Equilibrative nucleoside transporter 2 | 0 | 2 | 0 | 2 |
| Phosphatidylinositol 4-kinase type 2-beta | 0 | 2 | 0 | 3 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific | 0 | 1 | 0 | 1 |
| Equilibrative nucleoside transporter 1 | 0 | 2 | 0 | 2 |
| Phosphatidylinositol 4-kinase type 2-alpha | 0 | 2 | 0 | 3 |
| Solute carrier family 28 member 3 | 0 | 2 | 0 | 2 |
| Adenosine kinase | 0 | 1 | 0 | 2 |
| Phosphatidylinositol 4-kinase beta | 0 | 2 | 0 | 3 |
| 5-methylthioadenosine/S-adenosylhomocysteine deaminase | 0 | 0 | 0 | 1 |
| Adenosine transporter 1 | 0 | 0 | 0 | 1 |
| thioredoxin reductase | 2 | 0 | 0 | 2 |
| PPM1D protein | 1 | 0 | 0 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0 | 1 | 0 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | 2 | 0 | 0 | 2 |
| Spike glycoprotein | 0 | 1 | 2 | 3 |
| Replicase polyprotein 1ab | 0 | 1 | 2 | 3 |
| glucose-6-phosphate 1-dehydrogenase isoform b | 0 | 1 | 0 | 1 |
| Transmembrane protease serine 2 | 0 | 1 | 2 | 3 |
| ATP-binding cassette sub-family C member 3 | 0 | 3 | 0 | 3 |
| Multidrug resistance-associated protein 4 | 0 | 3 | 0 | 3 |
| Dihydrofolate reductase | 0 | 1 | 0 | 1 |
| DNA ligase | 0 | 1 | 0 | 1 |
| Interferon beta | 1 | 0 | 0 | 1 |
| Riboflavin-binding protein | 0 | 0 | 1 | 1 |
| Major prion protein | 0 | 0 | 1 | 1 |
| Amyloid-beta precursor protein | 0 | 1 | 0 | 1 |
| Histidine-rich protein PFHRP-II | 0 | 1 | 0 | 2 |
| Procathepsin L | 0 | 1 | 2 | 3 |
| Muscarinic acetylcholine receptor M2 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M4 | 0 | 1 | 0 | 1 |
| Cytochrome P450 3A4 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M5 | 0 | 1 | 0 | 1 |
| Alpha-2A adrenergic receptor | 0 | 1 | 0 | 1 |
| Replicase polyprotein 1a | 0 | 1 | 2 | 3 |
| Replicase polyprotein 1ab | 0 | 1 | 2 | 3 |
| Replicase polyprotein 1ab | 0 | 1 | 2 | 3 |
| Spike glycoprotein | 0 | 1 | 0 | 1 |
| Replicase polyprotein 1ab | 0 | 1 | 2 | 3 |
| Muscarinic acetylcholine receptor M1 | 0 | 1 | 0 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | 0 | 1 | 0 | 1 |
| Alpha-2B adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-2C adrenergic receptor | 0 | 1 | 0 | 1 |
| DNA ligase 1 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M3 | 0 | 1 | 0 | 1 |
| Serine/threonine-protein kinase mTOR | 0 | 1 | 0 | 1 |
| Nuclear receptor subfamily 4 group A member 2 | 0 | 0 | 1 | 1 |
| Beta-secretase 1 | 0 | 1 | 0 | 1 |
| Spike glycoprotein | 1 | 1 | 2 | 4 |
| Calcium-dependent protein kinase 1 | 0 | 0 | 1 | 1 |
| MO15-related protein kinase Pfmrk | 0 | 1 | 0 | 1 |
| DNA ligase A | 0 | 1 | 0 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | 0 | 2 | 0 | 2 |
| Sigma intracellular receptor 2 | 0 | 1 | 0 | 1 |
| Phosphoethanolamine N-methyltransferase | 0 | 1 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 3 | 0 | 3 |
| Sigma non-opioid intracellular receptor 1 | 0 | 1 | 0 | 1 |
| Angiotensin-converting enzyme 2 | 0 | 1 | 2 | 3 |
| Cysteine proteinase falcipain 2a | 0 | 1 | 0 | 1 |
| Cysteine proteinase falcipain 2a | 0 | 1 | 0 | 1 |
| Purine nucleoside phosphorylase | 0 | 1 | 0 | 1 |
| Luciferase | 1 | 0 | 0 | 1 |
| endonuclease IV | 1 | 0 | 0 | 1 |
| dopamine D1 receptor | 1 | 0 | 0 | 1 |
| ATAD5 protein, partial | 1 | 0 | 0 | 1 |
| NFKB1 protein, partial | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 2 | 0 | 0 | 2 |
| peripheral myelin protein 22 isoform 1 | 2 | 0 | 0 | 2 |
| vasopressin V1b receptor | 1 | 0 | 0 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | 1 | 0 | 0 | 1 |
| DNA polymerase iota isoform a (long) | 1 | 0 | 0 | 1 |
| histone acetyltransferase KAT2A isoform 1 | 1 | 0 | 0 | 1 |
| relaxin receptor 1 isoform 1 | 1 | 0 | 0 | 1 |
| muscarinic acetylcholine receptor M1 | 2 | 0 | 0 | 2 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | 0 | 1 | 0 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | 0 | 1 | 0 | 1 |
| Tumor necrosis factor | 0 | 1 | 0 | 1 |
| Cholinesterase | 0 | 1 | 0 | 1 |
| Acetylcholinesterase | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 0 | 1 | 0 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | 1 | 0 | 0 | 1 |
| Inositol monophosphatase 1 | 1 | 0 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 0 | 1 | 0 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 0 | 1 | 0 | 1 |
| Chitotriosidase-1 | 0 | 2 | 1 | 3 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | 0 | 1 | 0 | 1 |
| Endochitinase B1 | 0 | 2 | 1 | 3 |
| NS5 | 0 | 0 | 1 | 1 |
| interleukin 8 | 1 | 0 | 0 | 1 |
| Thrombopoietin | 1 | 0 | 0 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | 1 | 0 | 0 | 1 |
| farnesoid X nuclear receptor | 1 | 0 | 0 | 1 |
| peroxisome proliferator activated receptor gamma | 1 | 0 | 0 | 1 |
| alpha-galactosidase | 1 | 0 | 0 | 1 |
| chromobox protein homolog 1 | 1 | 0 | 0 | 1 |
| thyroid hormone receptor beta isoform 2 | 1 | 0 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 1 | 0 | 0 | 1 |
| urokinase-type plasminogen activator precursor | 1 | 0 | 0 | 1 |
| plasminogen precursor | 1 | 0 | 0 | 1 |
| urokinase plasminogen activator surface receptor precursor | 1 | 0 | 0 | 1 |
| geminin | 1 | 0 | 0 | 1 |
| cytochrome P450 3A4 isoform 1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | 1 | 0 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | 0 | 1 | 0 | 1 |
| Polymerase basic protein 2 | 0 | 0 | 1 | 1 |
| RNA-directed RNA polymerase catalytic subunit | 0 | 0 | 1 | 1 |
| Polymerase acidic protein | 0 | 0 | 1 | 1 |
| Cellular tumor antigen p53 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | 1 | 0 | 0 | 1 |
| Nuclear receptor ROR-gamma | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | 1 | 0 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | 0 | 1 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | 0 | 1 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | 0 | 1 | 0 | 1 |
| Adenosine receptor A1 | 0 | 1 | 0 | 1 |
| Genome polyprotein | 0 | 0 | 1 | 1 |
| GABA theta subunit | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | 1 | 0 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |