Fibrillary Chorea

Successive and rapid contractions of motor units associated with chronic nerve injury. The discharges arise from the peripheral aspects of regenerating nerves, and clinically impart a nearly continuous undulation of the body surface overlying the muscle. (Adams et al., Principles of Neurology, 6th ed, p1491)

Synonyms(7)

Synonym
Myokymia, Generalized
Fibrillary Chorea
Myokymia
Morvan's Fibrillary Chorea
Morvan's Chorea
Kymatism
Morvan Chorea

Research Excerpts

Overview

Excerpt	Reference
"Myokymia is a vermiform motion of muscle that can be found in conditions in which there is pathology to the peripheral nerve to that muscle."	( Keebler, P; Kinnett, D, 2001)
"Superior oblique myokymia is a rare movement disorder thought to be caused by vascular compression of the trochlear nerve."	( Dieterich, M; Naidich, TP; Schmid, UD; Yousry, I; Yousry, TA, 2002)
"Eyelid myokymia is an underreported side-effect of topiramate in patients with migraine, of unknown cause, so that in future, further studies are need to examine whether patients with migraine are predisposed or not to this adverse effect."	( Fernández-Izquierdo, S; Francés-Pont, I; Mallada-Frechin, J; Medrano-Martínez, V; Moltó-Jordá, JM; Pérez-Sempere, A; Piqueras-Rodríguez, L, 2015)
"Focal myokymia is an unusual EMG finding that is usually seen in demyelinating disorders, after radiation, or in neoplastic/inflammatory conditions."	( Baehring, JM; Bower, AS; Fisayo, A; Roy, B, 2022)

Context

Excerpt	Reference
"Palatolingual myokymia has only been reported in one human being."	( Bavegems, V; Bhatti, SF; Gielen, IM; Polis, I; Van Ham, LM; Van Soens, I; Vanhaesebrouck, AE; Vercauteren, G, 2010)

Treatment

Excerpt	Reference
"Eight presented eyelid myokymia after beginning treatment with topiramate (5,7%)."	( Fernández-Izquierdo, S; Francés-Pont, I; Mallada-Frechin, J; Medrano-Martínez, V; Moltó-Jordá, JM; Pérez-Sempere, A; Piqueras-Rodríguez, L, 2015)

Research

Studies (46)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	1 (2.17)	12.5806
2000's	21 (45.65)	18.1394
2010's	16 (34.78)	28.8240
2020's	8 (17.39)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
melatonin	low	2	0
phenytoin	low	3	0
acetazolamide	low	3	0
azathioprine	low	1	0
baclofen	medium	2	1
carbamazepine	low	5	0
diazepam	low	1	0
gabapentin	low	1	0
haloperidol	low	1	0
lorazepam	low	1	0
memantine	low	1	0
modafinil	low	1	0
propranolol	low	1	0
riluzole	low	1	0
prednisone	low	4	0
alanine	low	1	0
serine	low	1	0
phenylalanine	low	1	0
valine	low	1	0
threonine	low	1	0
methylprednisolone	low	2	0
2-methylpentane	low	1	0
n-hexane	low	1	0
ethylnitrosourea	low	1	0
phenyl acetate	low	1	0
oxcarbazepine	low	2	0
levobunolol	low	1	0
simvastatin	low	1	0
tiagabine	low	1	0
fluorodeoxyglucose f18	low	2	0
lacosamide	low	1	0
cannabidiol	low	1	0
flunarizine	low	1	0
D-fructopyranose	low	1	0
quinine	low	1	0
topiramate	low	1	0
cysteine	low	1	0
gadolinium dtpa	low	1	0
er-086526	low	2	0
jaw	low	1	0
cyclosporine	low	1	0

Protein Targets (654)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	14	0	0	14
pregnane X nuclear receptor	12	0	0	12
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	10	0	0	10
GALC protein	2	0	0	2
GLI family zinc finger 3	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
glucocorticoid receptor [Homo sapiens]	14	0	0	14
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	7	0	0	7
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	9	0	0	9
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
geminin	13	0	0	13
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	6	7	2	15
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	15
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	1	9
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	18	0	18
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	13
Carbonic anhydrase 2	0	5	2	13
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	5	0	5
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	0	7
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	7	0	7
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	8	0	8
5-hydroxytryptamine receptor 2A	0	3	1	4
Androgen receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	6	7	2	15
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit delta	6	7	2	15
Gamma-aminobutyric acid receptor subunit gamma-2	6	7	4	17
Gamma-aminobutyric acid receptor subunit alpha-5	6	7	2	15
Gamma-aminobutyric acid receptor subunit alpha-3	6	7	2	15
Cannabinoid receptor 1	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 4	0	4	1	8
Carbonic anhydrase 6	0	4	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	6	7	2	15
Gamma-aminobutyric acid receptor subunit alpha-2	6	7	2	15
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	2	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	7	2	15
Gamma-aminobutyric acid receptor subunit gamma-3	6	7	2	15
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	6	7	2	15
Adenosine receptor A2a	0	1	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	3	0	3
Cytochrome P450 2C19	0	6	0	6
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	2	10
Carbonic anhydrase	0	2	0	3
Kappa-type opioid receptor	0	2	0	2
Carbonic anhydrase 7	0	4	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	2	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
D(2) dopamine receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	6	7	4	17
Gamma-aminobutyric acid receptor subunit beta-3	6	7	2	15
Gamma-aminobutyric acid receptor subunit beta-2	6	7	4	17
Cholinesterase	0	4	0	4
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	5	0	6
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	6	7	2	15
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	6
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	6	7	2	15
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	4	0	5
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
Chain A, Ferritin light chain	3	0	0	3
interleukin 8	3	0	0	3
acetylcholinesterase	4	0	0	4
phosphopantetheinyl transferase	6	0	0	6
RAR-related orphan receptor gamma	7	0	0	7
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	12	0	0	12
Microtubule-associated protein tau	4	0	0	4
AR protein	14	0	0	14
thioredoxin glutathione reductase	4	0	0	4
EWS/FLI fusion protein	6	0	0	6
farnesoid X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	16	0	0	16
G	7	0	0	7
polyprotein	2	0	0	2
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	5	0	0	5
IDH1	5	0	0	5
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	3	0	0	3
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	3	0	0	3
DNA polymerase iota isoform a (long)	1	0	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	6	0	0	6
lamin isoform A-delta10	12	0	0	12
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	8	0	0	8
Glutamate receptor 2	4	0	0	4
Nuclear receptor ROR-gamma	3	0	0	3
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	8	0	0	8
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	7	0	0	7
NFKB1 protein, partial	3	0	0	3
regulator of G-protein signaling 4	8	0	0	8
67.9K protein	1	0	0	1
D(1A) dopamine receptor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
ATP-dependent phosphofructokinase	7	0	0	7
PPM1D protein	2	0	0	2
Acetylcholinesterase	0	3	0	3
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 2C11	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	1	4
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-2B adrenergic receptor	0	5	1	7
Alpha-2C adrenergic receptor	0	6	2	9
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	3	0	4
D(1A) dopamine receptor	0	6	1	8
Cytochrome P450 3A7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	7	1	8
Caspase-1	0	0	1	1
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	6	2	8
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Spike glycoprotein	5	0	0	5
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
USP1 protein, partial	5	0	0	5
thyroid stimulating hormone receptor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
mitogen-activated protein kinase 1	2	0	0	2
Vpr	1	0	0	1
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	6	0	6
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	5
Cytochrome P450 2J2	0	5	0	5
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Gamma-aminobutyric acid	0	2	1	3
glp-1 receptor, partial	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	3	4
ATP-dependent translocase ABCB1	0	7	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
5-hydroxytryptamine receptor 1A	0	11	2	14
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Translocator protein	0	1	0	1
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
pregnane X receptor	2	0	0	2
lethal factor (plasmid)	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
cytochrome P450 2D6	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
chromobox protein homolog 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
5-hydroxytryptamine receptor 4	0	6	0	6
Potassium channel subfamily K member 2	0	2	2	4
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	5	2	8
Adenosine receptor A3	0	3	1	4
Muscarinic acetylcholine receptor M1	0	5	1	6
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	6	2	10
Alpha-1B adrenergic receptor	0	5	1	6
Muscarinic acetylcholine receptor M3	0	4	1	5
Sodium-dependent noradrenaline transporter	0	7	0	7
Alpha-1D adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 1B	0	7	0	7
Sodium-dependent serotonin transporter	0	9	0	9
Histamine H1 receptor	0	4	0	4
D(3) dopamine receptor	0	5	1	8
5-hydroxytryptamine receptor 2B	0	6	1	7
Alpha-1A adrenergic receptor	0	6	1	7
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	8	0	8
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Histone deacetylase 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	3	1	6
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	4	0	0	4
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
Thrombopoietin	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
nonstructural protein 1	4	0	0	4
glucocerebrosidase	1	0	0	1
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Solute carrier family 22 member 1	0	5	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Beta-2 adrenergic receptor	0	4	0	5
Muscarinic acetylcholine receptor M2	0	2	0	2
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	3	1	5
D	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	1	1	2
D(2) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	3	1	6
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	1	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	3	1	4
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	3	0	3
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	0	1
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	1	3
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	2	5
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	1	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
Histamine H2 receptor	3	0	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 6	0	3	1	4
5-hydroxytryptamine receptor 7	0	4	0	4
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	4
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	4
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	4
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Beta-2 adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	4	1	5
Beta-3 adrenergic receptor	0	4	1	5
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
ClpP	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
huntingtin isoform 2	1	0	0	1
Solute carrier family 22 member 2	0	1	0	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Transporter	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
polyadenylate-binding protein 1	0	1	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	2	0	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Luciferase	2	0	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	3
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
endonuclease IV	1	0	0	1
GLS protein	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Parkin	2	0	0	2
pyruvate kinase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Ornithine decarboxylase	1	0	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Alpha-synuclein	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Pteridine reductase 1	0	2	0	2
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Smad3	1	0	0	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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