Page last updated: 2024-09-27

Familial Dysalbuminemic Hyperthyroxinemia

An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4.

Synonyms(2)

Synonym
Hyperthyroxinemia, Familial Dysalbuminemic
Familial Dysalbuminemic Hyperthyroxinemia

Research Excerpts

Research

Studies (16)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's2 (12.50)18.1394
2010's8 (50.00)28.8240
2020's6 (37.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
thyroxine0medium130
triiodothyronine0low30
isoleucine0low10
arginine0low10
methimazole0low10
thyronines0low10
triiodothyronine, reverse0low10

Protein Targets (156)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase2002
phosphopantetheinyl transferase2002
NFKB1 protein, partial1001
GLS protein1001
thyroid stimulating hormone receptor1001
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 23003
cytochrome P450 2C19 precursor1001
chromobox protein homolog 12002
flap endonuclease 11001
DNA polymerase iota isoform a (long)1001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Cytochrome P450 3A40001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase1001
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
acetylcholinesterase1001
GLI family zinc finger 32002
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
TDP1 protein3003
AR protein2002
aldehyde dehydrogenase 1 family, member A11001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
retinoic acid nuclear receptor alpha variant 11001
retinoid X nuclear receptor alpha1001
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha3003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x1001
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 13003
nuclear receptor ROR-gamma isoform 11001
survival motor neuron protein isoform d1001
lamin isoform A-delta103003
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Polyphenol oxidase 20203
Bile salt export pump0101
Bile salt export pump0202
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
Canalicular multispecific organic anion transporter 10101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
RAR-related orphan receptor gamma1001
USP1 protein, partial2002
apical membrane antigen 1, AMA12002
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein1001
G1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma2002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 22002
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Rap guanine nucleotide exchange factor 31001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0103
Cellular tumor antigen p532002
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
cytochrome P450 2C9, partial1001
glp-1 receptor, partial1001
glucocorticoid receptor [Homo sapiens]1001
glucocerebrosidase1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
geminin1001
peripheral myelin protein 221001
muscleblind-like protein 1 isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10011
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-60011
Adenosine receptor A10202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-20011
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
GABA theta subunit0011
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Gamma-aminobutyric acid receptor subunit epsilon0011
Solute carrier organic anion transporter family member 1B30001
Gamma-aminobutyric acid receptor subunit theta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]