Experimental High Pressure Neurological Syndrome

A syndrome related to increased atmospheric pressure and characterized by tremors, nausea, dizziness, decreased motor and mental performance, and SEIZURES. This condition may occur in those who dive deeply (c. 1000 ft) usually while breathing a mixture of oxygen and helium. The condition is associated with a neuroexcitatory effect of helium.

Synonym
High Pressure Neural Syndrome
HPNS
Experimental High Pressure Neurological Syndrome
High Pressure Neurological Syndrome, Experimental
High Pressure Neurological Syndrome
High Pressure Nervous Syndrome

Excerpt	Reference
"HPNS (high pressure neurological syndrome) is considered to be reversible condition of the nervous system caused by elevated (atmospheric) pressure."	( Mennel, HD; Stumm, G; Wenzel, J, 1997)
"HPNS is characterized by motor and cognitive impairments."	( Grossman, Y; Talpalar, AE, 2003)
"HPNS is characterized by tremor, sleep disorders, electroencephalographic changes, and impairment of cognitive and motor performances."	( Grossman, Y; Mor, A, 2006)
"HPNS is characterized by cognitive and motor decrements associated with sleep disorders, EEG changes, tremor, and convulsions that ultimately may lead to death."	( Grossman, Y; Mor, A, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	24 (27.91)	23.3326
1990's	44 (51.16)	12.5806
2000's	13 (15.12)	18.1394
2010's	5 (5.81)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	5
5-hydroxytryptophan	low	1
2,4-diaminobutyric acid	low	1
3,4-dihydroxyphenylacetic acid	low	3
glycine	low	2
hydrogen	low	4
pipecolic acid	low	2
niacinamide	low	1
nitrous oxide	low	2
2-amino-5-phosphonovalerate	low	9
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	low	1
sk&f-38393	low	1
1-(3-chlorophenyl)piperazine	low	1
homovanillic acid	low	2
phenytoin	low	1
hydroxyindoleacetic acid	low	1
7-chlorokynurenic acid	low	1
baclofen	low	1
carbamazepine	low	1
chlorzoxazone	low	1
diazepam	low	1
valproic acid	low	2
2-amino-7-phosphonoheptanoic acid	low	4
racemetirosine	low	1
gyki 52466	low	1
haloperidol	low	1
halothane	low	1
isoniazid	low	1
isoproterenol	low	1
ketanserin	low	1
kynurenic acid	low	2
lamotrigine	low	1
mephenesin	low	1
methyl parathion	low	1
muscimol	low	1
nipecotic acid	low	2
fenclonine	low	1
phenobarbital	low	1
pindolol	low	1
propranolol	low	1
quipazine	low	1
sulpiride	low	3
vigabatrin	low	1
benzimidazole	low	1
carbachol	low	2
pentylenetetrazole	low	1
alanine	low	1
aspartic acid	low	4
glutamine	low	2
apomorphine	low	1
zoxazolamine	low	1
barbituric acid	low	1
valine	low	1
tryptophan	low	1
gramine	low	1
quinoxalines	low	3
2-chloroadenosine	low	1
ephedrine	low	1
bicuculline	low	1
kainic acid	low	1
allylglycine	low	1
methionine sulfoximine	low	1
amiloride	low	1
n-methylaspartate	low	4
neon	low	1
argon	low	1
helium	medium	35
fluorine	low	1
metergoline	low	1
glutamic acid	low	3
proroxan	low	1
fomesafen	low	1
quinpirole	low	1
adenosine	low	1
abecarnil	low	1
3',4'-dichlorobenzamil	low	1
gamma-glutamylaminomethylsulfonic acid	low	1
heliox	low	5
ly 293558	low	1
proline	low	2
cyanopindolol	low	1
gabaculine	low	1
trimix	low	1
ouabain	low	1
strychnine	low	2
bemesetron	low	1
fg 9041	low	2
barium	low	1
cgp 39551	low	1
2-amino-5-phosphono-3-pentenoic acid	low	1
ergoline	low	1
calcimycin	low	1
picrotoxin	low	1
piperidines	low	1
cgs 12066b	low	1
carbidopa	low	1

Protein Targets (920)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
5-hydroxytryptamine receptor 3E	0	5	2	7
acetylcholinesterase	15	0	0	15
TDP1 protein	32	0	0	32
cytochrome P450 2D6	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
cytochrome P450 2D6 isoform 1	11	0	0	11
cellular tumor antigen p53 isoform a	8	0	0	8
cytochrome P450 2C19 precursor	11	0	0	11
cytochrome P450 2C9 precursor	8	0	0	8
thyroid hormone receptor beta isoform a	10	0	0	10
thyroid hormone receptor beta isoform 2	14	0	0	14
huntingtin isoform 2	5	0	0	5
peripheral myelin protein 22	12	0	0	12
cytochrome P450 3A4 isoform 1	16	0	0	16
muscarinic acetylcholine receptor M1	20	0	0	20
Gamma-aminobutyric acid receptor subunit pi	16	11	2	29
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
5-hydroxytryptamine receptor 3B	0	5	2	7
Bile salt export pump	0	24	0	24
Beta-1 adrenergic receptor	0	8	4	12
5-hydroxytryptamine receptor 1A	0	10	7	18
5-hydroxytryptamine receptor 2C	0	11	1	13
D(2) dopamine receptor	0	14	6	26
5-hydroxytryptamine receptor 2A	0	11	1	12
Gamma-aminobutyric acid receptor subunit beta-1	16	11	2	29
Alpha-1B adrenergic receptor	0	8	2	10
Gamma-aminobutyric acid receptor subunit delta	16	11	2	29
Gamma-aminobutyric acid receptor subunit gamma-2	16	11	4	31
D	0	11	0	12
5-hydroxytryptamine receptor 1A	0	17	2	20
Gamma-aminobutyric acid receptor subunit alpha-5	16	11	2	29
Gamma-aminobutyric acid receptor subunit alpha-3	16	11	2	29
Gamma-aminobutyric acid receptor subunit gamma-1	16	11	2	29
Gamma-aminobutyric acid receptor subunit alpha-2	16	11	2	29
Alpha-1D adrenergic receptor	0	8	2	10
5-hydroxytryptamine receptor 2A	0	12	3	18
5-hydroxytryptamine receptor 2C	0	12	2	15
Gamma-aminobutyric acid receptor subunit alpha-4	16	11	2	29
Gamma-aminobutyric acid receptor subunit gamma-3	16	11	2	29
5-hydroxytryptamine receptor 1B	0	13	0	13
5-hydroxytryptamine receptor 1D	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	16	11	2	29
5-hydroxytryptamine receptor 1F	0	7	0	7
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	10	1	11
Sodium-dependent serotonin transporter	0	9	0	10
5-hydroxytryptamine receptor 7	0	7	0	7
5-hydroxytryptamine receptor 7	0	7	1	9
Alpha-1B adrenergic receptor	0	2	2	7
Glutamate receptor ionotropic, NMDA 1	1	25	5	36
5-hydroxytryptamine receptor 2B	0	9	2	13
Alpha-1A adrenergic receptor	0	9	2	11
5-hydroxytryptamine receptor 3A	0	5	2	8
Histamine H2 receptor	10	0	1	13
5-hydroxytryptamine receptor 6	0	8	1	10
Beta-2 adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	15	6	23
Gamma-aminobutyric acid receptor subunit alpha-1	16	11	4	31
Gamma-aminobutyric acid receptor subunit beta-3	16	11	2	29
Gamma-aminobutyric acid receptor subunit beta-2	16	11	4	31
Glutamate receptor ionotropic, NMDA 2A	0	22	5	32
Glutamate receptor ionotropic, NMDA 2B	0	22	5	32
Glutamate receptor ionotropic, NMDA 2C	0	22	5	32
Glutamate receptor ionotropic, NMDA 2D	0	22	5	32
5-hydroxytryptamine receptor 3D	0	5	2	7
Glutamate receptor ionotropic, NMDA 3B	0	22	5	32
5-hydroxytryptamine receptor 3C	0	5	2	7
GABA theta subunit	16	11	2	29
Canalicular multispecific organic anion transporter 1	0	12	0	12
Gamma-aminobutyric acid receptor subunit epsilon	16	11	2	29
Glutamate receptor ionotropic, NMDA 3A	0	22	5	32
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
Bloom syndrome protein isoform 1	22	0	0	22
peripheral myelin protein 22 isoform 1	12	0	0	12
D(1A) dopamine receptor	13	0	0	13
lamin isoform A-delta10	30	0	0	30
Glutamate receptor 1	0	13	2	18
Glutamate receptor ionotropic, kainate 3	0	11	0	14
ATP-dependent phosphofructokinase	26	0	0	26
thioredoxin reductase	34	0	0	34
nonstructural protein 1	6	0	0	6
arylsulfatase A	22	0	0	22
histone acetyltransferase KAT2A isoform 1	12	0	0	12
neuropeptide S receptor isoform A	6	0	0	6
Chain A, Beta-lactamase	6	0	0	6
glp-1 receptor, partial	8	0	0	8
Smad3	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
NPYLR7B	0	0	3	3
67.9K protein	7	0	0	7
IDH1	10	0	0	10
vasopressin V1b receptor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	15	0	0	15
flap endonuclease 1	10	0	0	10
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	29	0	0	29
survival motor neuron protein isoform d	9	0	0	9
relaxin receptor 1 isoform 1	1	0	0	1
high affinity choline transporter 1 isoform a	0	2	0	2
relaxin receptor 2 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Renin	0	1	0	1
Integrin beta-3	5	0	1	6
Heat shock protein HSP 90-alpha	0	3	2	5
Integrin alpha-IIb	5	0	1	6
Adenosine receptor A3	0	4	4	9
Endoplasmin	0	2	2	4
Adenosine receptor A1	0	5	1	7
Adenosine receptor A1	0	1	0	1
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	5	11
Adenosine receptor A2b	0	1	2	5
Adenosine receptor A2b	0	3	1	6
Adenosine receptor A1	0	3	2	7
Adenosine receptor A2a	0	4	1	7
Adenosine receptor A2a	0	0	1	1
Adenosine receptor A1	0	0	2	2
Adenosine deaminase	0	1	0	2
Adenylate cyclase type 5	0	3	0	3
Ataxin-2	10	0	0	10
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
Sodium- and chloride-dependent GABA transporter 2	0	5	0	5
Sodium- and chloride-dependent GABA transporter 3	0	4	0	4
Sodium- and chloride-dependent betaine transporter	0	4	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
regulator of G-protein signaling 4	19	0	0	19
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
M-phase phosphoprotein 8	8	0	0	8
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, HADH2 protein	13	0	0	13
Chain B, HADH2 protein	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	7	0	0	7
endonuclease IV	10	0	0	10
RGS12	2	0	0	2
phosphopantetheinyl transferase	14	0	0	14
NFKB1 protein, partial	7	0	0	7
GLS protein	24	0	0	24
Microtubule-associated protein tau	16	0	0	16
Thrombopoietin	5	0	0	5
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
thyroid stimulating hormone receptor	19	0	0	19
hypothetical protein, conserved	3	0	0	3
lysosomal alpha-glucosidase preproprotein	6	0	0	6
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	23	0	0	23
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
DNA polymerase beta	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	5	1	7
Zinc finger protein mex-5	0	0	1	1
lethal factor (plasmid)	10	0	0	10
Chain A, Cruzipain	5	0	0	5
RAR-related orphan receptor gamma	14	0	0	14
USP1 protein, partial	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
estrogen receptor 2 (ER beta)	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
glucocorticoid receptor [Homo sapiens]	16	0	0	16
glucocerebrosidase	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
transcriptional regulator ERG isoform 3	3	0	0	3
Potassium channel subfamily K member 2	0	2	1	3
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cellular tumor antigen p53	12	0	0	12
Potassium voltage-gated channel subfamily A member 3	0	0	1	1
Acetylcholinesterase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
Glutamate receptor 2	8	10	2	23
Glutamate receptor 3	0	10	2	15
Glutamate receptor 4	0	10	2	15
Glutamate receptor ionotropic, kainate 1	0	8	2	13
Glutamate receptor ionotropic, kainate 2	0	8	3	14
Glutamate receptor ionotropic, kainate 4	0	8	0	11
Glutamate receptor ionotropic, kainate 5	0	8	0	11
Vesicular glutamate transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	9	6	15
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	4	12
Gamma-aminobutyric acid receptor subunit beta-3	0	9	4	13
Gamma-aminobutyric acid receptor subunit alpha-5	0	9	5	14
Gamma-aminobutyric acid receptor subunit alpha-3	0	9	3	12
Gamma-aminobutyric acid receptor subunit alpha-2	0	9	4	13
Gamma-aminobutyric acid receptor subunit alpha-6	0	9	2	11
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	21	0	0	21
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
retinoid X nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	23	0	0	23
Histone H2A.x	6	0	0	6
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Platelet-derived growth factor receptor beta	0	0	0	1
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine kinase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Carbonic anhydrase 1	0	2	0	8
Carbonic anhydrase 2	0	2	0	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	4
Proton-coupled amino acid transporter 1	0	4	0	4
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	1	0	3
progesterone receptor	10	0	0	10
estrogen-related nuclear receptor alpha	19	0	0	19
pregnane X nuclear receptor	9	0	0	9
G	5	0	0	5
alpha-galactosidase	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Alpha-synuclein	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	8	4	12
Inositol hexakisphosphate kinase 1	5	0	0	5
cytochrome P450 2C9, partial	5	0	0	5
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR	0	1	0	1
acid sphingomyelinase	2	0	0	2
Membrane primary amine oxidase	0	2	0	2
Solute carrier family 22 member 1	0	4	0	5
Prothrombin	0	1	1	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Cationic trypsin	0	1	0	1
Coagulation factor XI	0	1	0	1
Plasma kallikrein	0	1	0	2
Vitamin K-dependent protein C	0	1	0	1
Urokinase-type plasminogen activator	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Sodium/hydrogen exchanger 1	0	2	0	2
Sodium/hydrogen exchanger 3	0	2	0	2
Trypsin-3	0	1	0	1
Amiloride-sensitive sodium channel subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	5	0	5
Sodium/hydrogen exchanger 2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium/hydrogen exchanger 5	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Sodium/hydrogen exchanger	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
GLI family zinc finger 3	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
farnesoid X nuclear receptor	6	0	0	6
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	9	0	0	9
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid stimulating hormone receptor	8	0	0	8
vitamin D3 receptor isoform VDRA	8	0	0	8
Tryptophan 5-hydroxylase 1	0	1	0	1
D(3) dopamine receptor	0	7	1	11
Alpha-2B adrenergic receptor	0	4	2	6
D(2) dopamine receptor	0	5	0	5
D(1A) dopamine receptor	0	11	4	19
D(4) dopamine receptor	0	8	3	16
D(1B) dopamine receptor	0	5	0	7
Alpha-2C adrenergic receptor	0	4	2	6
Alpha-2A adrenergic receptor	0	4	2	6
D(1B) dopamine receptor	0	5	0	5
D(4) dopamine receptor	0	5	1	6
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
D(3) dopamine receptor	0	10	4	19
5-hydroxytryptamine receptor 3A	0	6	1	7
Spike glycoprotein	4	0	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 4	0	3	0	3
D	0	4	0	4
ATPase family AAA domain-containing protein 5	6	0	0	6
Sigma non-opioid intracellular receptor 1	0	6	0	6
5-hydroxytryptamine receptor 3B	0	6	1	7
Chain A, Ferritin light chain	5	0	0	5
Metabotropic glutamate receptor 6	0	1	3	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
ATAD5 protein, partial	9	0	0	9
activating transcription factor 6	8	0	0	8
Gamma-aminobutyric acid type B receptor subunit 2	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Polyphenol oxidase 2	0	2	0	2
15-lipoxygenase, partial	6	0	0	6
GALC protein	4	0	0	4
Inositol monophosphatase 1	2	0	0	2
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	1	0	2
GTPase KRas	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Membrane primary amine oxidase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	8	2	10
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
ClpP	2	0	0	2
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	5	0	0	5
TSHR protein	1	0	0	1
polyprotein	5	0	0	5
Parkin	3	0	0	3
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
hexokinase-4 isoform 1	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
type-1 angiotensin II receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
glucokinase regulatory protein	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
serine/threonine-protein kinase PLK1	1	0	0	1
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	2	0	0	2
streptokinase A precursor	0	0	1	1
Amyloid-beta precursor protein	1	0	0	1
D(1A) dopamine receptor	3	2	0	5
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	4	3	9
Muscarinic acetylcholine receptor M4	0	3	2	7
Muscarinic acetylcholine receptor M1	0	5	1	8
Muscarinic acetylcholine receptor M3	0	4	1	6
Muscarinic acetylcholine receptor M4	0	4	0	5
Muscarinic acetylcholine receptor M5	0	4	0	5
Muscarinic acetylcholine receptor M5	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Muscarinic acetylcholine receptor M2	0	4	0	5
Muscarinic acetylcholine receptor M1	0	5	3	10
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	4	3	9
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Bile salt export pump	0	6	0	6
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2C9	0	6	0	6
UDP-glucuronosyltransferase 2B7	0	3	0	6
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	5	0	8
Cytochrome P450 2J2	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	6	0	6
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
muscleblind-like protein 1 isoform 1	3	0	0	3
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Beta-2 adrenergic receptor	0	7	5	13
Beta-1 adrenergic receptor	0	6	2	11
Gamma-aminobutyric acid	0	2	1	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	2	4
ATP-dependent translocase ABCB1	0	4	0	6
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	2	0	2
Chain A, Glutamate Receptor Subunit 2	0	2	0	2
Chain B, Glutamate Receptor Subunit 2	0	2	0	2
fatty acid synthase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Glutamate receptor 1	0	7	2	10
Glutamate receptor 2	0	8	2	11
Glutamate receptor 3	0	5	2	8
Glutamate receptor 4	0	7	1	9
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	2
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	4	5
Gamma-aminobutyric acid receptor subunit rho-2	0	0	2	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	5	2	8
Metabotropic glutamate receptor 5	0	1	3	5
Metabotropic glutamate receptor 8	0	0	1	1
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	5	2	7
Glutamate receptor ionotropic, kainate 3	0	5	0	5
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Glycine receptor subunit alpha-1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Estrogen receptor beta	0	0	0	1
Estrogen receptor	0	0	0	1
Glutamate receptor 1	0	0	0	1
Glutamate receptor 2	0	0	0	1
Glutamate receptor 4	0	0	0	1
Glutamate receptor 3	0	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
EWS/FLI fusion protein	6	0	0	6
caspase-3	1	0	0	1
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Cocaine esterase	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	3
5-hydroxytryptamine receptor 4	0	7	0	7
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Cytochrome P450 3A4	0	4	0	5
Alpha-2A adrenergic receptor	0	7	2	12
Beta-2 adrenergic receptor	0	6	1	9
Angiotensin-converting enzyme	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Alpha-2B adrenergic receptor	0	4	1	8
Alpha-2C adrenergic receptor	0	6	3	12
Adenylate cyclase type 3	0	1	0	1
Sodium-dependent dopamine transporter	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	0	2
Histamine H2 receptor	0	4	0	5
Alpha-1D adrenergic receptor	0	4	2	9
Beta-3 adrenergic receptor	0	4	1	5
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Kappa-type opioid receptor	0	1	0	2
Alpha-1A adrenergic receptor	0	2	3	8
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	5	0	6
Mu-type opioid receptor	0	3	2	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	2	0	2
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	4	0	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
Solute carrier family 22 member 8	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Beta-1 adrenergic receptor	0	1	2	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Beta-3 adrenergic receptor	0	5	3	8
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	2	2
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	5
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	2	3
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
DNA polymerase kappa isoform 1	4	0	0	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
dopamine D1 receptor	4	0	0	4
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
5-hydroxytryptamine receptor 1B	0	4	1	6
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	2
Synaptic vesicular amine transporter	0	2	0	2
Mitogen-activated protein kinase 13	0	1	0	1
Aryl hydrocarbon receptor	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	2	1	3
Histamine H3 receptor	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
pyruvate kinase	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Cytochrome P450 2D6	0	2	0	2
Endothelin receptor type B	0	1	0	1
Substance-K receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 1E	0	0	0	1
Prostaglandin E2 receptor EP4 subtype	0	0	0	1
Delta-type opioid receptor	0	1	1	3
Prostaglandin E2 receptor EP3 subtype	0	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Histamine H4 receptor	0	0	0	1
Heparanase	0	0	1	1
heat shock protein beta-1	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
D-amino-acid oxidase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
PPM1D protein	1	0	0	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Peroxisomal sarcosine oxidase	0	0	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
interferon gamma precursor	0	0	0	1
Dipeptidyl peptidase 4	0	0	1	1
Dipeptidyl peptidase 4	0	0	1	1
Mu-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Neutrophil cytosol factor 1	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Glycine receptor subunit alpha-1	0	1	0	1
Glycine receptor subunit beta	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Carbonic anhydrase 3	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 9	0	1	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 4	0	0	0	1
Substance-P receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Arginase 1	0	1	0	1
pregnane X receptor	1	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Mitogen-activated protein kinase 1	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Experimental High Pressure Neurological Syndrome

Synonyms(6)

Research Excerpts

Overview

Research

Studies (86)

Protein Targets (920)

Experimental High Pressure Neurological Syndrome

Synonyms(6)

Research Excerpts

Overview

Research

Studies (86)

Drugs Studied (111)

Protein Targets (920)