Page last updated: 2024-09-28

Equine Strongyle Infections

Infection of horses with parasitic nematodes of the superfamily STRONGYLOIDEA. Characteristics include the development of hemorrhagic nodules on the abdominal peritoneum.

Synonyms(4)

Synonym
Strongylosis, Equine
Infections, Equine Strongyle
Equine Strongyle Infections
Strongyle Infections, Equine

Research

Studies (280)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990153 (54.64)23.3326
1990's46 (16.43)12.5806
2000's42 (15.00)18.1394
2010's34 (12.14)28.8240
2020's5 (1.79)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbamates0medium172
hydrochloric acid0low10
hydrogen carbonate0low10
albendazole0low70
dichlorvos0low80
diethylcarbamazine0low10
fenbendazole0medium4911
tetramisole0low10
mebendazole0low120
niclosamide0low10
oxibendazole0medium232
piperazine0low80
praziquantel0medium73
thiabendazole0medium401
benzimidazole0low120
trichlorfon0low150
carbon disulfide0low10
phenothiazine0low20
thiophenes0low10
framycetin0low10
thiazoles0low80
ephedrine0low10
dithiothreitol0low10
fructosamine0low10
parbendazole0low10
levamisole0low20
iodine0low10
phenyl acetate0low10
cambendazole0medium161
amitraz0low10
oxfendazole0medium142
closantel0low20
pergolide0low10
tioxidazole0low10
glucuronic acid0low10
methotrexate0low10
fibrin0low10
elastin0low10
dipyrone0low10
pyrantel0medium233
pyrantel pamoate0medium323
thromboxane b20low10
morantel0low30
selenium0low20
pyrantel tartrate0low10
avermectin b(1)a0medium21
4-toluoyl chloride phenylhydrazone0low10
doramectin0low10
dextrothyroxine0medium9916
tannins0low10
warfarin0low20
caseins0low10
moxidectin0medium2810
febantel0medium101

Protein Targets (515)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase6006
Luciferase120012
glp-1 receptor, partial4004
hypoxia-inducible factor 1 alpha subunit8008
RAR-related orphan receptor gamma140014
ATAD5 protein, partial6006
Fumarate hydratase7007
TDP1 protein160016
GLI family zinc finger 3140014
AR protein220022
caspase 7, apoptosis-related cysteine protease5005
nuclear receptor subfamily 1, group I, member 3150015
progesterone receptor120012
glucocorticoid receptor [Homo sapiens]140014
retinoic acid nuclear receptor alpha variant 1190019
retinoid X nuclear receptor alpha170017
estrogen-related nuclear receptor alpha200020
farnesoid X nuclear receptor140014
pregnane X nuclear receptor190019
estrogen nuclear receptor alpha240024
polyprotein7007
67.9K protein6006
peroxisome proliferator activated receptor gamma110011
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
caspase-35005
IDH15005
euchromatic histone-lysine N-methyltransferase 29009
aryl hydrocarbon receptor140014
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
v-jun sarcoma virus 17 oncogene homolog (avian)100010
nuclear receptor subfamily 1, group I, member 29009
Histone H2A.x7007
cellular tumor antigen p53 isoform a5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 24004
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2190019
histone deacetylase 9 isoform 37007
heat shock protein beta-18008
mitogen-activated protein kinase 15005
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
geminin160016
Vif0001
peripheral myelin protein 22130013
survival motor neuron protein isoform d5005
muscleblind-like protein 1 isoform 16006
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lamin isoform A-delta10150015
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Voltage-dependent calcium channel gamma-2 subunit100010
Bile salt export pump010010
Interferon beta100010
Cellular tumor antigen p53170017
Integrin beta-34004
Integrin alpha-IIb4004
Methionine aminopeptidase0404
Glutamate receptor 2100010
Fatty-acid amide hydrolase 10404
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 10404
ATPase family AAA domain-containing protein 5150015
Ataxin-2150015
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
cytochrome P450 family 3 subfamily A polypeptide 4100010
cytochrome P450 2D69009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
thyroid hormone receptor beta isoform a7007
potassium voltage-gated channel subfamily H member 2 isoform d6006
nuclear factor erythroid 2-related factor 2 isoform 1150015
cytochrome P450 3A4 isoform 19009
Gamma-aminobutyric acid receptor subunit pi9009
Alpha-2A adrenergic receptor0404
Gamma-aminobutyric acid receptor subunit beta-19009
Gamma-aminobutyric acid receptor subunit delta9009
Gamma-aminobutyric acid receptor subunit gamma-29009
Gamma-aminobutyric acid receptor subunit alpha-59009
Gamma-aminobutyric acid receptor subunit alpha-39009
Gamma-aminobutyric acid receptor subunit gamma-19009
Gamma-aminobutyric acid receptor subunit alpha-29009
Gamma-aminobutyric acid receptor subunit alpha-49009
Gamma-aminobutyric acid receptor subunit gamma-39009
Gamma-aminobutyric acid receptor subunit alpha-69009
Gamma-aminobutyric acid receptor subunit alpha-19009
Gamma-aminobutyric acid receptor subunit beta-39009
Gamma-aminobutyric acid receptor subunit beta-29009
Peroxisome proliferator-activated receptor alpha1001
GABA theta subunit9009
Gamma-aminobutyric acid receptor subunit epsilon9009
pregnane X receptor3003
SMAD family member 25005
SMAD family member 35005
estrogen receptor 2 (ER beta)7007
peroxisome proliferator-activated receptor delta100010
activating transcription factor 65005
nuclear factor NF-kappa-B p105 subunit isoform 12002
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Chain A, GTPase KRas, isoform 2B0011
Chain A, GTPase KRas, isoform 2B0011
Membrane primary amine oxidase 0101
Cytochrome P450 2B10102
Cytochrome P450 1A10102
GTPase KRas0011
Polyunsaturated fatty acid 5-lipoxygenase0102
Glutaminyl-peptide cyclotransferase0101
Lanosterol 14-alpha demethylase0101
Membrane primary amine oxidase0101
Glutaminyl-peptide cyclotransferase0101
nuclear receptor ROR-gamma isoform 15005
aldehyde dehydrogenase 1 family, member A18008
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, BCL-2-RELATED PROTEIN A10011
glucose-6-phosphate dehydrogenase0101
SUMO-10101
phosphopantetheinyl transferase3003
USP1 protein, partial6006
TSHR protein2002
Smad32002
PINK12002
regulator of G-protein signaling 44004
G3003
Parkin2002
bromodomain adjacent to zinc finger domain 2B2002
hexokinase0101
Bloom syndrome protein isoform 15005
vitamin D3 receptor isoform VDRA3003
flap endonuclease 14004
serine/threonine-protein kinase PLK11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)4004
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 13003
streptokinase A precursor0011
bcl-2-like protein 11 isoform 10011
Solute carrier family 22 member 1 0101
Long-chain-fatty-acid--AMP ligase FadD320101
Rap guanine nucleotide exchange factor 32002
Epidermal growth factor receptor0202
HLA class I histocompatibility antigen, B alpha chain 3003
Receptor tyrosine-protein kinase erbB-20101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Sporulation initiation phosphotransferase F0101
Neutrophil elastase0101
Cytochrome P450 3A40101
Adenosine receptor A30404
Cytochrome P450 2C9 0303
Alpha-1B adrenergic receptor0404
Sporulation kinase A0101
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0404
Acetylcholinesterase0202
Thromboxane-A synthase 0101
Mitogen-activated protein kinase 10202
Prostaglandin G/H synthase 20202
Alpha-1A adrenergic receptor0404
Spike glycoprotein91010
Guanine nucleotide-binding protein G2002
Sodium-dependent dopamine transporter 0404
Mitogen-activated protein kinase 140202
Chitinase0202
Rap guanine nucleotide exchange factor 42002
Inositol hexakisphosphate kinase 13003
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
cytochrome P450 2C9, partial3003
Chain A, Ferritin light chain4004
Chain A, Cruzipain3003
endonuclease IV2002
thioredoxin reductase6006
Microtubule-associated protein tau7007
nonstructural protein 13003
glucocerebrosidase1001
peripheral myelin protein 22 isoform 12002
DNA polymerase beta3003
M-phase phosphoprotein 84004
interleukin 82002
acetylcholinesterase5005
15-lipoxygenase, partial5005
thyroid stimulating hormone receptor4004
Nuclear receptor ROR-gamma2002
Acetylcholinesterase0101
Chain A, 2-oxoglutarate Oxygenase5005
polyunsaturated fatty acid lipoxygenase ALOX123003
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Histamine H2 receptor5005
Nuclear receptor subfamily 1 group I member 20022
Nuclear receptor subfamily 1 group I member 20022
PPM1D protein7007
EWS/FLI fusion protein9009
thyroid stimulating hormone receptor3003
Caspase-71001
caspase-31001
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Lethal factor0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 10303
Carbonic anhydrase 20314
Carbonic anhydrase 40303
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase0303
Carbonic anhydrase 70101
Carbonic anhydrase 90101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0101
Carbonic anhydrase 130101
Carbonic anhydrase 5B, mitochondrial0101
Carbonic anhydrase 150202
dopamine D1 receptor3003
atrial natriuretic peptide receptor 1 precursor2002
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
ATP-dependent phosphofructokinase4004
GALC protein3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
cytochrome P450 2C9 precursor2002
huntingtin isoform 22002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lethal factor (plasmid)4004
Tyrosine-protein kinase ABL10314
Proto-oncogene tyrosine-protein kinase Src0303
Vascular endothelial growth factor receptor 20202
Disintegrin and metalloproteinase domain-containing protein 171001
Calmodulin-domain protein kinase 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
acid sphingomyelinase1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0202
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0203
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0202
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Thrombopoietin1001
arylsulfatase A2002
pyruvate kinase2002
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Spike glycoprotein0101
Replicase polyprotein 1ab0101
cytochrome P450 2D6 isoform 13003
NPC intracellular cholesterol transporter 1 precursor2002
cytochrome P450 2C19 precursor2002
D(1A) dopamine receptor2002
glucose-6-phosphate 1-dehydrogenase isoform b0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 11001
muscarinic acetylcholine receptor M12002
pyruvate kinase PKM isoform b1001
Aurora kinase A0101
Transmembrane protease serine 20101
3-phosphoinositide-dependent protein kinase 10101
Tyrosine-protein kinase JAK20101
Procathepsin L0101
Tyrosine-protein kinase Lyn0101
Ornithine decarboxylase1001
Platelet-derived growth factor receptor beta0101
Replicase polyprotein 1a0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Mast/stem cell growth factor receptor Kit0101
Fibroblast growth factor receptor 10101
Serine/threonine-protein kinase B-raf0101
Protein kinase C alpha type0101
RAC-alpha serine/threonine-protein kinase0101
Receptor-type tyrosine-protein kinase FLT30101
Alpha-synuclein1304
Signal transducer and activator of transcription 30101
Mitogen-activated protein kinase 80101
Glycogen synthase kinase-3 beta0101
D(1A) dopamine receptor1001
Angiopoietin-1 receptor0101
Anoctamin-10101
Angiotensin-converting enzyme 2 0101
Hematopoietic prostaglandin D synthase0101
Adenosine receptor A2a0202
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
GLS protein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
5-hydroxytryptamine receptor 40404
5-hydroxytryptamine receptor 1A0101
Cytochrome P450 2D60101
D(2) dopamine receptor0213
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
D(2) dopamine receptor0101
D(1A) dopamine receptor0202
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0415
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60202
D(2) dopamine receptor0213
Potassium voltage-gated channel subfamily H member 20101
5-hydroxytryptamine receptor 4 0101
D0101
Sigma non-opioid intracellular receptor 10101
5-hydroxytryptamine receptor 3B0101
apical membrane antigen 1, AMA11001
NADPH oxidase 10101
Snq2p0001
lysosomal alpha-glucosidase preproprotein1001
rac GTPase-activating protein 1 isoform a0101
Cytochrome P450 1A20202
Aldo-keto reductase family 1 member B10202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Amine oxidase [flavin-containing] A0101
Cannabinoid receptor 10202
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Pleiotropic ABC efflux transporter of multiple drugs0102
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
galactokinase1001
Chain A, Methionine aminopeptidase0101
BRCA11001
P531001
Endothelin receptor type B1001
Endothelin-1 receptor1001
Methionine aminopeptidase 20101
Methionine aminopeptidase 10112
Peptidyl-prolyl cis-trans isomerase FKBP1A0011
Reverse transcriptase/RNaseH 0101
Multidrug and toxin extrusion protein 10101
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2A10001
Albumin0011
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]