Page last updated: 2024-09-28

Eosinophilic Leukemia, Acute

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.

Synonyms(2)

Synonym
Eosinophilic Leukemia, Acute
Leukemia, Eosinophilic, Acute

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (5.00)23.3326
1990's16 (80.00)12.5806
2000's1 (5.00)18.1394
2010's2 (10.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
azelastine0low10
1-(5-isoquinolinesulfonyl)-2-methylpiperazine0low30
hydroxyurea0low10
ketotifen0low10
prednisolone0low10
prednisone0low10
methylprednisolone0low10
pyrazines0low20
luminol0low10
tetradecanoylphorbol acetate0low40
1-hexadecyl-2-acetyl-glycero-3-phosphocholine0low60
imatinib mesylate0low20
l 0120low10
n-formylmethionine leucyl-phenylalanine0low30
tretinoin0low10
arachidonic acid0low10
calcimycin0low20
phosphatidylcholines0low10
bucladesine0low30
transforming growth factor beta0low20
transforming growth factor alpha0low10
2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one0low20

Protein Targets (379)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
thioredoxin reductase8008
ATAD5 protein, partial3003
GLS protein6006
TDP1 protein9009
regulator of G-protein signaling 45005
67.9K protein2002
Parkin3003
bromodomain adjacent to zinc finger domain 2B3003
IDH14004
euchromatic histone-lysine N-methyltransferase 26006
nuclear factor erythroid 2-related factor 2 isoform 26006
huntingtin isoform 22002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 13003
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
survival motor neuron protein isoform d3003
D(1A) dopamine receptor2002
Ataxin-27007
ATP-dependent phosphofructokinase6006
Chain A, Cruzipain4004
Platelet-activating factor receptor0202
Inositol monophosphatase 13003
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Beta-lactamase3003
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
15-lipoxygenase, partial1001
phosphopantetheinyl transferase3003
USP1 protein, partial3003
Microtubule-associated protein tau4004
thioredoxin glutathione reductase4004
aldehyde dehydrogenase 1 family, member A15005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
Bloom syndrome protein isoform 14004
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA5005
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear receptor ROR-gamma isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 13003
cytochrome P450 3A4 isoform 14004
histone acetyltransferase KAT2A isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
caspase-1 isoform alpha precursor1001
lamin isoform A-delta104004
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit pi4004
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Prostaglandin G/H synthase 1 0001
Trypsin0101
Coagulation factor VII0101
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Aromatase0101
Tissue factor0101
Fatty acid-binding protein, adipocyte0112
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Prostaglandin G/H synthase 20113
Nuclear receptor subfamily 4 group A member 20011
Histamine H2 receptor2002
10 kDa heat shock protein, mitochondrial0202
Calmodulin 0001
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20001
Solute carrier organic anion transporter family member 2A10001
Fatty acid-binding protein 50101
Fatty acid-binding protein 50011
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
GABA theta subunit4004
Gamma-aminobutyric acid receptor subunit epsilon4004
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Transient receptor potential cation channel subfamily V member 20101
Solute carrier organic anion transporter family member 1B10202
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
NFKB1 protein, partial2002
thyroid stimulating hormone receptor4004
alpha-galactosidase1001
cytochrome P450 2C19 precursor2002
chromobox protein homolog 15005
flap endonuclease 12002
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Cytochrome P450 3A40114
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Fumarate hydratase3003
EWS/FLI fusion protein3003
polyprotein3003
ATP-dependent translocase ABCB10101
Cytochrome P450 2D60213
Muscarinic acetylcholine receptor M10303
5-hydroxytryptamine receptor 2C0303
Alpha-1A adrenergic receptor0101
Histamine H1 receptor0314
Alpha-1B adrenergic receptor0101
5-hydroxytryptamine receptor 2B0505
Alpha-1A adrenergic receptor0303
Potassium voltage-gated channel subfamily H member 20101
Histamine H3 receptor0101
glp-1 receptor, partial3003
vasopressin V1b receptor1001
cAMP-dependent protein kinase type I-alpha regulatory subunit0011
cAMP-dependent protein kinase type II-beta regulatory subunit0011
cAMP-dependent protein kinase catalytic subunit beta isoform 10011
geminin6006
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
neuropeptide S receptor isoform A2002
cAMP-dependent protein kinase catalytic subunit beta isoform 30011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
endonuclease IV1001
ClpP1001
electroneutral potassium-chloride cotransporter KCC20011
TSHR protein1001
Smad31001
apical membrane antigen 1, AMA11001
nonstructural protein 13003
estrogen-related nuclear receptor alpha8008
glucocerebrosidase1001
arylsulfatase A2002
LacZ protein (plasmid)0011
XBP10101
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 12002
type-1 angiotensin II receptor0101
D(1A) dopamine receptor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
glucokinase regulatory protein1001
mitogen-activated protein kinase 11001
serine/threonine-protein kinase PLK11001
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20001
DNA damage-inducible transcript 3 protein0101
Vpr1001
streptokinase A precursor0011
Rap guanine nucleotide exchange factor 31001
Amyloid-beta precursor protein1102
Alpha-synuclein1102
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
heat shock protein 90, putative0001
Phosphodiesterase 0101
Multidrug resistance-associated protein 40405
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
acetylcholinesterase4004
AR protein8008
retinoic acid nuclear receptor alpha variant 16006
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha7007
Histone H2A.x2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
ATP-binding cassette sub-family C member 30404
Bile salt export pump0505
Carbonic anhydrase 20102
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Carbonic anhydrase 40101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Carbonic anhydrase 5A, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Carbonic anhydrase 90102
Gamma-aminobutyric acid receptor subunit gamma-10101
Canalicular multispecific organic anion transporter 10404
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Luciferase2002
SMAD family member 21001
SMAD family member 31001
GLI family zinc finger 36006
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]5005
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor2002
peroxisome proliferator-activated receptor delta2002
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
thyroid stimulating hormone receptor2002
thyroid hormone receptor beta isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 14004
DNA repair protein RAD52 homolog isoform a0001
Voltage-dependent calcium channel gamma-2 subunit3003
Tyrosine-protein kinase ABL10112
Cytochrome P450 2C80001
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0011
Platelet-derived growth factor receptor alpha0112
Glutamate receptor 23003
Cytochrome P450 3A50001
Spike glycoprotein2002
ATPase family AAA domain-containing protein 54004
RAR-related orphan receptor gamma3003
cytochrome P450 2D61001
peroxisome proliferator activated receptor gamma2002
cytochrome P450 2D6 isoform 11001
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
atrial natriuretic peptide receptor 2 precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
peripheral myelin protein 222002
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Glutathione reductase, mitochondrial0101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0303
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 1B0202
D(3) dopamine receptor0202
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 60202
6-phosphogluconate dehydrogenase, decarboxylating0101
tumor necrosis factor1001
importin subunit beta-1 isoform 11001
NEDD8-activating enzyme E1 regulatory subunit isoform a0101
NEDD8-conjugating enzyme Ubc120101
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Queuine tRNA-ribosyltransferase0101
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
G2002
nuclear receptor subfamily 1, group I, member 22002
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Inositol hexakisphosphate kinase 12002
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial2002
Formyl peptide receptor-related sequence 10011
fMet-Leu-Phe receptor0224
N-formyl peptide receptor 20022
FML2_HUMAN 0011
luciferase0001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Cellular tumor antigen p533003
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0112
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
pregnane X receptor2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Nuclear receptor ROR-gamma1113
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Luciferin 4-monooxygenase0011
Protein kinase C alpha type0112
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
Chain A, Nuclear Receptor ROR-beta0101
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
Caspase-71001
thyroid hormone receptor beta isoform a1001
caspase-31001
heat shock protein beta-11001
M-phase phosphoprotein 81001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Ornithine decarboxylase0001
Adenosine receptor A30202
Retinoic acid receptor alpha0227
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]