Page last updated: 2024-09-28

Entrapment Neuropathy, Tarsal Tunnel

Entrapment of the distal branches of the posterior TIBIAL NERVE (which divides into the medial plantar, lateral plantar, and calcanial nerves) in the tarsal tunnel, which lies posterior to the internal malleolus and beneath the retinaculum of the flexor muscles of the foot. Symptoms include ankle pain radiating into the foot which tends to be aggravated by walking. Examination may reveal Tinel's sign (radiating pain following nerve percussion) over the tibial nerve at the ankle, weakness and atrophy of the small foot muscles, or loss of sensation in the foot. (From Foot Ankle 1990;11(1):47-52)

Synonyms(6)

Synonym
Posterior Tibial Nerve Neuralgia
Entrapment Neuropathy, Tarsal Tunnel
Tarsal Tunnel Syndrome
Tibial Neuropathy, Tarsal Tunnel
Tarsal Tunnel Tibial Neuropathy
Tarsal Tunnel Entrapment Neuropathy

Research Excerpts

Overview

ExcerptReference
"Tarsal tunnel syndrome is a rare form of entrapment neuropathy."( Algahtani, H; Broome, RJ; Brown, JD; Watson, BV, 2002)

Research

Studies (42)

TimeframeStudies, This Condition (%)All Conditions %
pre-199020 (47.62)23.3326
1990's7 (16.67)12.5806
2000's5 (11.90)18.1394
2010's8 (19.05)28.8240
2020's2 (4.76)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetazolamide0low10
fentanyl0low10
glyphosate0low10
lidocaine0low10
isoflurane0low10
thyroxine0low10
prednisone0low10
uridine monophosphate0low10
technetium0low10
trolamine salicylate0low10
cortisone0low20
hydrocodone0low10
nitrofurantoin0low10
indocyanine green0low10
vitamin b 120low10
folic acid0low10

Protein Targets (408)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase2002
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase5005
GALC protein1001
GLI family zinc finger 35005
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha6006
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A1001
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 11001
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin3003
peripheral myelin protein 223003
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi3104
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Carbonic anhydrase0101
Solute carrier family 22 member 60202
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0606
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10217
Carbonic anhydrase 20216
Carbonic anhydrase 20202
Cytochrome P450 1A20101
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Cytochrome P450 2A60101
Cytochrome P450 2C9 0101
5-hydroxytryptamine receptor 2A0101
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-13104
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40214
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10202
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-63104
Adenosine receptor A2a0202
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0303
Cytochrome P450 2C190101
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Carbonic anhydrase 5A, mitochondrial0215
Carbonic anhydrase0101
Kappa-type opioid receptor0303
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0303
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90215
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10303
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit3104
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 40202
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon3104
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV1001
dopamine D1 receptor1001
pregnane X receptor2002
RAR-related orphan receptor gamma7007
GLS protein2002
TDP1 protein8008
AR protein7007
aldehyde dehydrogenase 1 family, member A14004
progesterone receptor4004
regulator of G-protein signaling 42002
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 12002
heat shock protein beta-12002
flap endonuclease 12002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
Glucocorticoid receptor0415
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 431001
Multidrug and toxin extrusion protein 10303
Luciferase2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
Solute carrier family 22 member 1 0202
Nuclear receptor subfamily 1 group I member 20022
ATP-dependent translocase ABCB10202
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0314
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0303
Mu-type opioid receptor0101
Potassium voltage-gated channel subfamily H member 20303
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
glp-1 receptor, partial1001
USP1 protein, partial3003
thyroid stimulating hormone receptor2002
glucocerebrosidase3003
alpha-galactosidase1001
activating transcription factor 61001
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 22002
DNA polymerase beta1001
Cellular tumor antigen p536006
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30203
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
phosphopantetheinyl transferase2002
lamin isoform A-delta105005
Mas-related G-protein coupled receptor member X20011
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Cruzipain1001
interleukin 81001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 22002
SMAD family member 32002
Microtubule-associated protein tau3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
estrogen receptor 2 (ER beta)3003
EWS/FLI fusion protein2002
farnesoid X nuclear receptor2002
G2002
67.9K protein1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor3003
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform 23003
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 12002
DNA polymerase kappa isoform 13003
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Voltage-dependent calcium channel gamma-2 subunit2002
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0112
Prostaglandin G/H synthase 10203
Procathepsin L0101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0011
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Glutamate receptor 22002
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20213
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0033
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor1001
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Nuclear receptor ROR-gamma3003
Aldo-keto reductase family 1 member C2 0101
Spike glycoprotein1001
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Inositol hexakisphosphate kinase 12002
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10203
cytochrome P450 2C9, partial2002
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
IDH12002
mitogen-activated protein kinase 11001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
acetylcholinesterase1001
ATAD5 protein, partial1001
thioredoxin glutathione reductase2002
cytochrome P450 2D61001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
streptokinase A precursor0011
lethal factor (plasmid)1001
Bile salt export pump0101
Estrogen receptor0011
Caspase-71001
60 kDa chaperonin 0101
Estrogen receptor beta0011
10 kDa chaperonin 0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
CDGSH iron-sulfur domain-containing protein 10202
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain B, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain B, orotidine monophosphate decarboxylase0101
Chain B, PyrR bifunctional protein0011
Orotidine 5'-phosphate decarboxylase0101
Uridine 5'-monophosphate synthase0101
UMP-CMP kinase 0001
Orotidine 5'-phosphate decarboxylase 0101
Protein cereblon0101
Protein argonaute-20011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]