Page last updated: 2024-09-27

Eastern Equine Encephalitis

A form of arboviral encephalitis (primarily affecting equines) endemic to eastern regions of North America. The causative organism (ENCEPHALOMYELITIS VIRUS, EASTERN EQUINE) may be transmitted to humans via the bite of AEDES mosquitoes. Clinical manifestations include the acute onset of fever, HEADACHE, altered mentation, and SEIZURES followed by coma. The condition is fatal in up to 50% of cases. Recovery may be marked by residual neurologic deficits and EPILEPSY. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)

Synonyms(4)

Synonym
Encephalomyelitis, Eastern Equine
Eastern Equine Encephalomyelitis
Eastern Equine Encephalitis
Eastern Equine Encephalomyelitis Virus Infection

Research

Studies (10)

TimeframeStudies, This Condition (%)All Conditions %
pre-19906 (60.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's4 (40.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetone0low10
quinacrine0low10
hydrogen carbonate0low10
phenytoin0low10
chloramphenicol0low10
histidine0low10
acridines0low10
streptomycin0low10
trypan red0low10
cortisone0low10
cystine0low10
ro13-99040low10
agar0low10
acyclovir0low10

Protein Targets (332)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
TDP1 protein7007
glucocorticoid receptor [Homo sapiens]2002
estrogen-related nuclear receptor alpha3003
thyroid hormone receptor beta isoform 22002
lamin isoform A-delta103003
Chain A, Ferritin light chain2002
thioredoxin reductase5005
Microtubule-associated protein tau2002
Smad32002
aldehyde dehydrogenase 1 family, member A15005
alpha-galactosidase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
flap endonuclease 15005
DNA polymerase iota isoform a (long)3003
DNA topoisomerase 2-alpha0001
Acetylcholinesterase0202
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Thymidine kinase 0101
phosphopantetheinyl transferase1001
GLS protein3003
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein2002
arylsulfatase A3003
euchromatic histone-lysine N-methyltransferase 26006
activating transcription factor 62002
Histone H2A.x1001
Bloom syndrome protein isoform 12002
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Solute carrier family 22 member 1 0001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Solute carrier family 22 member 60001
Bile salt export pump0202
Bile salt export pump0505
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0202
Cytochrome P450 2J20101
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60001
Thymidine kinase 0101
Solute carrier family 22 member 80001
Canalicular multispecific organic anion transporter 10101
Thymidine kinase0101
interleukin 81001
GLI family zinc finger 33003
AR protein3003
retinoic acid nuclear receptor alpha variant 13003
farnesoid X nuclear receptor1001
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha3003
G2002
cytochrome P450 2D61001
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
aryl hydrocarbon receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 13003
geminin3003
streptokinase A precursor0011
lethal factor (plasmid)1001
Dihydroxyacetone phosphate acyltransferase0001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cellular tumor antigen p531001
Cytochrome P450 3A40101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Inositol hexakisphosphate kinase 12002
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial2002
endonuclease IV2002
dopamine D1 receptor2002
pregnane X receptor1001
RAR-related orphan receptor gamma1001
progesterone receptor1001
regulator of G-protein signaling 43003
retinoid X nuclear receptor alpha1001
peroxisome proliferator-activated receptor delta1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
peripheral myelin protein 22 isoform 12002
chromobox protein homolog 13003
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi2103
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Gamma-aminobutyric acid receptor subunit beta-12103
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Glycine receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit gamma-32103
Gamma-aminobutyric acid receptor subunit alpha-62103
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 431001
GABA theta subunit2103
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon2103
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
ATAD5 protein, partial2002
histone acetyltransferase KAT2A isoform 12002
Carbonic anhydrase 120001
Carbonic anhydrase 10103
Carbonic anhydrase 20103
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40102
Carbonic anhydrase 60001
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0102
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Carbonic anhydrase 40001
Carbonic anhydrase 150102
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Gamma-aminobutyric acid 0101
nuclear receptor subfamily 1, group I, member 31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
cytochrome P450 2C9 precursor1001
thyroid hormone receptor beta isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
transcriptional regulator ERG isoform 31001
nuclear receptor ROR-gamma isoform 11001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Dihydrofolate reductase 0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
N0101
Fumarate hydratase1001
USP1 protein, partial1001
NPYLR7B0011
polyprotein1001
67.9K protein1001
IDH11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
cystic fibrosis transmembrane conductance regulator0101
D(1A) dopamine receptor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
tumor susceptibility gene 101 protein1001
DNA polymerase kappa isoform 11001
Glutathione reductase, mitochondrial0101
Riboflavin-binding protein0112
Major prion protein0011
Major prion protein0101
Histidine-rich protein PFHRP-II0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10011
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
DNA-directed RNA polymerase subunit alpha0101
DNA-directed RNA polymerase subunit omega0101
DNA-directed RNA polymerase subunit beta'0101
DNA-directed RNA polymerase subunit beta0101
Replicase polyprotein 1ab0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Phospholipase A2, membrane associated0101
Phospholipase A2, membrane associated0101
Acidic phospholipase A2 20101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
Trypanothione reductase0202
D(3) dopamine receptor0202
D(1A) dopamine receptor1001
Aldehyde oxidase 10101
Cholinesterase0101
Aldehyde oxidase0101
Cyclic GMP-AMP synthase0101
Ataxin-21001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
vitamin D3 receptor isoform VDRA1001
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Protein-arginine deiminase type-40202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]