Page last updated: 2024-09-28

Double Tooth

Two teeth united during development by the union of their tooth germs; the teeth may be joined by the enamel of their crowns, by their root dentin, or by both.

Synonyms(5)

Synonym
Fused Mandibular Incisors
Double Tooth
Fused Teeth
Teeth, Fused
Incisors, Fused Mandibular

Research

Studies (10)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (10.00)23.3326
1990's1 (10.00)12.5806
2000's2 (20.00)18.1394
2010's6 (60.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nitric acid0low10
nitrous oxide0low10
haloperidol0low20
methyl salicylate0low10
bromodeoxyuridine0low10
zirconium0low10
5-bromo-4-chloro-3-indolyl beta-galactoside0low10
inositol 3-phosphate0low10
phenylephrine hydrochloride0low10
sodium hypochlorite0low10
salicylates0low10
exudates0low10

Protein Targets (292)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 81001
pregnane X receptor1001
RAR-related orphan receptor gamma4004
ATAD5 protein, partial2002
TDP1 protein3003
Microtubule-associated protein tau1001
AR protein4004
aldehyde dehydrogenase 1 family, member A11001
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha4004
bromodomain adjacent to zinc finger domain 2B1001
arylsulfatase A2002
IDH12002
euchromatic histone-lysine N-methyltransferase 23003
nuclear receptor subfamily 1, group I, member 21001
cellular tumor antigen p53 isoform a1001
Nuclear hormone receptor family member daf-120011
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 23003
serine/threonine-protein kinase mTOR isoform 12002
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin3003
peripheral myelin protein 223003
survival motor neuron protein isoform d1001
muscarinic acetylcholine receptor M12002
Voltage-dependent calcium channel gamma-2 subunit2002
Thymidine kinase, cytosolic0101
Glutamate receptor 22002
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma2002
Spike glycoprotein3003
Thymidine kinase0001
Thymidylate kinase0101
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
acetylcholinesterase1001
glp-1 receptor, partial2002
thioredoxin reductase2002
15-lipoxygenase, partial1001
Fumarate hydratase1001
NFKB1 protein, partial1001
GLI family zinc finger 33003
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 41001
cytochrome P450 family 3 subfamily A polypeptide 41001
EWS/FLI fusion protein1001
nonstructural protein 11001
farnesoid X nuclear receptor1001
cytochrome P450 2D61001
polyprotein1001
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-31001
Adenylate cyclase type 1 0101
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear factor erythroid 2-related factor 2 isoform 12002
nuclear receptor ROR-gamma isoform 11001
cytochrome P450 3A4 isoform 11001
transient receptor potential cation channel subfamily V member 11001
lethal factor (plasmid)1001
Cocaine esterase0101
Gamma-aminobutyric acid receptor subunit pi1001
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20101
Bile salt export pump0101
Albumin0011
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10203
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40102
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10202
Cytochrome P450 2C9 0101
Angiotensin-converting enzyme0101
Integrin alpha-40101
D(2) dopamine receptor0215
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0202
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30101
D(1A) dopamine receptor0203
D(4) dopamine receptor0215
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0202
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
Gamma-aminobutyric acid receptor subunit alpha-61001
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
C-8 sterol isomerase0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Kappa-type opioid receptor0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
Mu-type opioid receptor0213
Glutamate receptor ionotropic, NMDA 1 0101
D(3) dopamine receptor0215
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1002
5-hydroxytryptamine receptor 2A0101
D(1A) dopamine receptor1102
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0202
AP-2 complex subunit sigma0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
Potassium voltage-gated channel subfamily H member 20202
TAR DNA-binding protein 431001
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
GABA theta subunit1001
Canalicular multispecific organic anion transporter 10101
D0101
Sodium channel protein type 2 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
Transient receptor potential cation channel subfamily V member 40101
Gamma-aminobutyric acid receptor subunit epsilon1001
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
ATP-dependent phosphofructokinase1001
Luciferase2002
estrogen receptor 2 (ER beta)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
histone deacetylase 9 isoform 31001
lamin isoform A-delta102002
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase0101
Carbonic anhydrase 70101
Carbonic anhydrase 90101
Carbonic anhydrase0101
Carbonic anhydrase 130101
Carbonic anhydrase 5B, mitochondrial0101
Chain A, 2-oxoglutarate Oxygenase1001
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
peroxisome proliferator activated receptor gamma1001
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Cellular tumor antigen p531001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
mitogen-activated protein kinase 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]