Page last updated: 2024-09-28

Dissociative Identity Disorder

A dissociative disorder in which the individual adopts two or more distinct personalities. Each personality is a fully integrated and complex unit with memories, behavior patterns and social friendships. Transition from one personality to another is sudden.

Synonyms(5)

Synonym
Dissociative Identity Disorder
Dual Personality
Multiple Identity Disorder
Multiple Personality Disorder
Multiple Personalities

Research Excerpts

Overview

ExcerptReference
"Multiple personality disorder is the classification given a person for whom two or more distinct personalities are diagnosed."( Beer, D; Beer, J, 1994)

Treatment

ExcerptReference
"This psychotherapy is used for treating multiple personality disorders."( Sugiyama, T, 2018)

Research

Studies (74)

TimeframeStudies, This Condition (%)All Conditions %
pre-199032 (43.24)23.3326
1990's20 (27.03)12.5806
2000's13 (17.57)18.1394
2010's9 (12.16)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3,4-methylenedioxyamphetamine0low20
alprazolam0low10
amobarbital0low50
carbamazepine0medium41
ethyl loflazepate0low10
mianserin0low20
mirtazapine0low20
nortriptyline0low10
risperidone0low20
trifluoperazine0low10
thiazoles0low10
sabinene0low10
tranylcypromine0low10
4-methoxyamphetamine0low10
fenoxycarb0low10
sertraline0low10
perospirone0low10
freedom0low10
technetium tc 99m exametazime0low10
id0low10
quetiapine fumarate0low10
olanzapine0low10
eye0low10
ego0low440

Protein Targets (338)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C010313
5-hydroxytryptamine receptor 2A010313
5-hydroxytryptamine receptor 1A08210
Sodium-dependent noradrenaline transporter 09110
Sodium-dependent dopamine transporter0314
5-hydroxytryptamine receptor 1B0729
5-hydroxytryptamine receptor 1D0426
5-hydroxytryptamine receptor 1F0426
5-hydroxytryptamine receptor 2B09312
5-hydroxytryptamine receptor 60224
Sodium-dependent serotonin transporter011314
Sodium-dependent serotonin transporter0516
5-hydroxytryptamine receptor 7 0426
5-hydroxytryptamine receptor 5A0224
5-hydroxytryptamine receptor 5B0224
5-hydroxytryptamine receptor 3A0325
Sodium-dependent dopamine transporter 0617
5-hydroxytryptamine receptor 4 0224
5-hydroxytryptamine receptor 3B0325
TDP1 protein9009
AR protein6006
glucocorticoid receptor [Homo sapiens]3003
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha7007
peroxisome proliferator activated receptor gamma2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
thyroid hormone receptor beta isoform 25005
nuclear receptor ROR-gamma isoform 12002
lamin isoform A-delta107007
Gamma-aminobutyric acid receptor subunit pi3104
Bromodomain-containing protein 40011
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-13104
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Gamma-aminobutyric acid receptor subunit alpha-63104
Cholecystokinin receptor type A0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Cholecystokinin receptor type A0101
GABA theta subunit3104
ATPase family AAA domain-containing protein 51001
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon3104
farnesoid X nuclear receptor1001
Chain A, Beta-lactamase2002
acetylcholinesterase3003
RAR-related orphan receptor gamma2002
USP1 protein, partial3003
thyroid stimulating hormone receptor5005
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha4004
IDH12002
euchromatic histone-lysine N-methyltransferase 25005
thyroid hormone receptor beta isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 21001
mitogen-activated protein kinase 13003
geminin8008
Vpr1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Bile salt export pump0101
Bile salt export pump0909
Albumin0033
Major prion protein0011
Cellular tumor antigen p535005
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0303
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20909
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
Canalicular multispecific organic anion transporter 10505
P2X purinoceptor 40101
Luciferase1001
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit1001
GLI family zinc finger 33003
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor2002
retinoid X nuclear receptor alpha1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear factor erythroid 2-related factor 2 isoform 12002
Voltage-dependent calcium channel gamma-2 subunit2002
Glutamate receptor 22002
5-hydroxytryptamine receptor 3E0202
phosphopantetheinyl transferase3003
ATAD5 protein, partial4004
Fumarate hydratase2002
GLS protein3003
aldehyde dehydrogenase 1 family, member A12002
regulator of G-protein signaling 43003
cytochrome P450 family 3 subfamily A polypeptide 43003
EWS/FLI fusion protein4004
cytochrome P450 2D63003
polyprotein2002
arylsulfatase A2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
D(1A) dopamine receptor4004
vitamin D3 receptor isoform VDRA6006
chromobox protein homolog 13003
potassium voltage-gated channel subfamily H member 2 isoform d2002
huntingtin isoform 22002
ras-related protein Rab-9A4004
5-hydroxytryptamine receptor 4010010
5-hydroxytryptamine receptor 3B0202
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20808
Muscarinic acetylcholine receptor M40909
5-hydroxytryptamine receptor 1A05510
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50909
Alpha-2A adrenergic receptor012012
Muscarinic acetylcholine receptor M10819
D(2) dopamine receptor0707
Alpha-1B adrenergic receptor0718
Alpha-2B adrenergic receptor011011
Alpha-2C adrenergic receptor012012
D0505
D(3) dopamine receptor0404
Alpha-2B adrenergic receptor0415
Muscarinic acetylcholine receptor M30808
Endothelin receptor type B0101
D(1A) dopamine receptor0808
D(4) dopamine receptor0505
Alpha-2C adrenergic receptor0415
Alpha-2A adrenergic receptor0415
Alpha-1D adrenergic receptor0718
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Histamine H2 receptor0606
Alpha-1D adrenergic receptor0808
Endothelin-1 receptor0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 2A011011
5-hydroxytryptamine receptor 2C011011
Histamine H1 receptor0202
5-hydroxytryptamine receptor 70505
Alpha-1A adrenergic receptor0505
Type-2 angiotensin II receptor0303
Histamine H1 receptor09110
D(3) dopamine receptor0909
5-hydroxytryptamine receptor 2B010010
Alpha-1A adrenergic receptor0819
5-hydroxytryptamine receptor 3A0303
Histamine H2 receptor4208
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 60708
Spike glycoprotein5005
D(2) dopamine receptor09110
Inositol monophosphatase 14004
5-hydroxytryptamine receptor 3D0202
5-hydroxytryptamine receptor 3C0202
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
Transporter0707
ATP-dependent phosphofructokinase1001
glp-1 receptor, partial3003
cytochrome P450 2D6 isoform 15005
cytochrome P450 2C19 precursor5005
cytochrome P450 2C9 precursor2002
TAR DNA-binding protein 431001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
dopamine D1 receptor1001
Thrombopoietin2002
67.9K protein3003
NPC intracellular cholesterol transporter 1 precursor3003
cellular tumor antigen p53 isoform a2002
atrial natriuretic peptide receptor 2 precursor3003
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 13003
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 13003
muscarinic acetylcholine receptor M14004
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Integrin beta-32002
Integrin alpha-IIb2002
Cytochrome P450 2C80202
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D60404
Cytochrome P450 2D30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2C190303
D(1A) dopamine receptor2002
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Cytochrome P450 2D40101
peroxisome proliferator-activated receptor delta1001
aryl hydrocarbon receptor1001
lysosomal alpha-glucosidase preproprotein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
FAD-linked sulfhydryl oxidase ALR0001
ATP-dependent translocase ABCB10305
Cytochrome P450 3A40404
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0707
UDP-glucuronosyltransferase 1A40001
Adenosine receptor A10101
D(4) dopamine receptor0202
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Disintegrin and metalloproteinase domain-containing protein 171001
Sigma non-opioid intracellular receptor 10202
Transporter0202
Nuclear receptor subfamily 3 group C member 3 0707
Chain A, JmjC domain-containing histone demethylation protein 3A2002
thioredoxin reductase1001
Smad33003
thyroid stimulating hormone receptor1001
peripheral myelin protein 22 isoform 11001
transcriptional regulator ERG isoform 31001
survival motor neuron protein isoform d2002
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
PPM1D protein1001
nonstructural protein 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Interferon beta1001
Transcriptional activator protein LuxR0101
D(1B) dopamine receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
Envelope glycoprotein0011
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Lysine-specific histone demethylase 1A0203
Cytochrome P450 1A10101
Cytochrome P450 1A20101
Cytochrome P450 2E10101
Cytochrome P450 2A60101
Cytochrome P450 4B10101
Amine oxidase [flavin-containing] B0101
Cytochrome P450 3A50101
Cytochrome P450 2A70101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0203
Cytochrome P450 3A70101
Cytochrome P450 2F10101
Amine oxidase [flavin-containing] B0203
Cytochrome P450 2C180101
Cytochrome P450 4F20101
Cytochrome P450 4F80101
Cytochrome P450 4A110101
Cytochrome P450 4F30101
Cytochrome P450 1B10101
Cytochrome P450 2A130101
Cytochrome P450 4A220101
Vitamin D 25-hydroxylase0101
Cytochrome P450 2U10101
Cytochrome P450 2W10101
Trace amine-associated receptor 10011
Cytochrome P450 2S10101
Cytochrome P450 3A43 0101
REST corepressor 30101
Genome polyprotein 0101
15-lipoxygenase, partial1001
NFKB1 protein, partial1001
Microtubule-associated protein tau1001
apical membrane antigen 1, AMA11001
NADPH oxidase 10101
glucocerebrosidase1001
Snq2p0001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
DNA repair protein RAD52 homolog isoform a0001
lethal factor (plasmid)1001
Ubiquitin carboxyl-terminal hydrolase 10101
Lysozyme C-10101
Glycoprotein hormones alpha chain1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Calmodulin-10011
Trypanothione reductase0202
C-8 sterol isomerase0101
Pleiotropic ABC efflux transporter of multiple drugs0102
Calmodulin 0011
Guanine nucleotide-binding protein G1001
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
WD repeat-containing protein 480101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]