Direct Hyperbilirubinemia, Neonatal

Accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin.

Synonym
Direct Hyperbilirubinemia, Neonatal
Hyperbilirubinemia, Neonatal
Hyperbilirubinemia During Infancy
Indirect Hyperbilirubinemia, Neonatal
Neonatal Hyperbilirubinemia

Excerpt	Reference
"Neonatal hyperbilirubinemia is a common clinical condition caused mainly by the increased production and decreased excretion of bilirubin."	( Jin, YX; Li, CE; Li, YZ; Shi, Y; Xia, ZW; Xu, LQ; Yu, SC; Zhang, ZL; Zhong, WW, 2007)
"Severe neonatal hyperbilirubinemia is associated with chronic bilirubin encephalopathy (kernicterus)."	( Chung, M; Ip, S; Lau, J; Trikalinos, TA, 2009)
"Neonatal hyperbilirubinemia is associated with various clinical comorbidities."	( M Abo El Fotoh, WM; Rizk, MS, 2016)
"Neonatal hyperbilirubinemia is frequently seen condition in the NICU."	( Farahbakhsh, N; Sharma, D; Sharma, P; Shastri, S, 2017)
"Neonatal hyperbilirubinemia is a frequently encountered problem."	( Abdel Aziz, RA; El-Mazary, AM; Saidii, AA, 2018)
"Suspected neonatal hyperbilirubinemia is a common reason for contact with the healthcare system."	( Ebbesen, F; Kristensen, SR; Krøgholt, T; Munkholm, SB; Szecsi, PB, 2018)
"Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates."	( Cayabyab, R; Ramanathan, R, 2019)
"Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due to infection, ischemia, and hypoxia."	( Fang, J; Krishtal, O; Lai, K; Li, CY; Li, WP; Li, XY; Maximyuk, O; Ni, K; Qi, X; Shi, HB; Shi, HS; Song, XL; Wang, F; Wang, LY; Xu, TL; Yin, SK, 2020)
"Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries."	( Aye, NSS; Htun, Y; Itoh, S; Kusaka, T; Oo, AK; Oo, H; Sin, KS; Suzuki, H; Yasuda, S; Yu, KZ, 2020)
"Neonatal hyperbilirubinemia is a common condition that frequently requires treatment with phototherapy and less commonly by exchange transfusion, especially in preterm infants."	( Miletin, J; O'Sullivan, A; Raba, AA, 2020)
"Neonatal hyperbilirubinemia is a common medical emergency in early neonatal period."	( Agrawal, A; Choubey, BP; Dubey, P; Shrivastava, J; Thakur, V, 2021)
"Early recognition of neonatal hyperbilirubinemia is essential for prevention of bilirubin neurotoxicity and its long-term sequelae."	( Ezeaka, VC; Farouk, ZL; Musa, BM; Okolo, A; Usman, F, 2021)
"Neonatal hyperbilirubinemia is a serious neonatal problem which has hazardous effects on the neonates when the level of indirect bilirubin is increased to the levels that could cause kernicterus."	( Abu-Risha, S; Al-Ashmawy, GM; Elfarargy, MS; Khattab, H, 2021)
"Neonatal hyperbilirubinemia is observed in most newborns, and 5-15% of neonates require phototherapy."	( Kiviranta, P; Kuitunen, I; Renko, M; Sankilampi, U, 2022)
"Neonatal hyperbilirubinemia is one of the most common conditions for neonate inpatients."	( Ahmad, JM; Angelica, D; Ayuningtyas, W; Etika, R; Handayani, KD; Hendrarto, TW; Kaban, RK; Liem, KD; Oktaviana, N; Pratama, DC; Putra, AJE; Rohsiswatmo, R; Sampurna, MTA; Utomo, MT; Visuddho, V; Wandita, S; Zakiyah, R, 2022)

Excerpt	Reference
"Neonatal hyperbilirubinemia has traditionally been screened by either total serum bilirubin or transcutaneous bilirubin."	( Albert, AY; Basso, M; Hadad, K; Jung, B; Lyon, ME; Wang, L, 2017)

Excerpt	Reference
"Early detection and treatment of neonatal hyperbilirubinemia is important in the prevention of bilirubin-induced encephalopathy."	( Birchwood, G; Hegyi, T; Mehta, R; Ostfeld, B; Petrova, A, 2006)
"Diagnosis and treatment of neonatal hyperbilirubinemia uses population and hour-based norms for total serum bilirubin and assessment of risk factors."	( Bennett, SR; Bernstein, HH; Brennan, B, 2007)
"Sequelae of severe neonatal hyperbilirubinemia constitute a substantial disease burden in areas where effective conventional phototherapy is unavailable."	( Brearley, AM; Emokpae, AA; Lund, TC; Olusanya, BO; Slusher, TM; Stevenson, DK; Vaucher, YE; Vreman, HJ; Wong, RJ, 2015)
"Phototherapy is the main treatment for neonatal hyperbilirubinemia."	( Hansen, TW, 2016)
"Whether neonatal hyperbilirubinemia and/or phototherapy increase the risk of autism spectrum disorder (ASD) is unclear."	( Croen, L; Kuzniewicz, MW; McCulloch, CE; Newman, TB; Walsh, EM; Wu, YW, 2016)
"Infants readmitted for neonatal hyperbilirubinemia requiring phototherapy are less likely to exclusively breastfeed than infants who are not readmitted for phototherapy."	( Cowperthwaite, M; Kovaric, K; McDaniel, CE; Thompson, G, 2020)
"To investigate the incidence of severe neonatal hyperbilirubinemia and the management on the treatment and follow-up of this disease in Jiangsu Province, China."	( Deng, XY; Dong, XY; Gao, Y; Han, SP; Hu, YH; Li, QQ; Li, SS; Lu, HY; Pan, ZJ; Qiao, Y; Wan, J; Wang, FD; Wang, J; Wang, JX; Wang, WY; Wu, MF; Xu, Y; Yan, JM; Yang, L; Yin, YJ; Yu, ZB; Zhou, JJ; Zhu, RP, 2020)
"The effectiveness of phototherapy for neonatal hyperbilirubinemia based on Danish clinical trials is presented."	( Donneborg, ML; Ebbesen, F; Vandborg, PK, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	13 (1.98)	23.3326
1990's	0 (0.00)	12.5806
2000's	153 (23.29)	18.1394
2010's	332 (50.53)	28.8240
2020's	159 (24.20)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
benzyl alcohol	low	1	0
carbon monoxide	medium	11	1
choline	low	1	0
salicylic acid	low	1	0
glycine	low	3	0
glycerol	medium	2	2
melatonin	low	1	0
taurine	low	1	0
acetaminophen	low	2	0
bupivacaine	low	1	0
clofibrate	medium	8	3
fenofibrate	medium	1	1
flurbiprofen	low	1	0
ibuprofen	low	2	0
isoflurane	low	1	0
metformin	medium	2	1
methadone	low	1	0
apnea	low	3	0
phenobarbital	medium	6	2
risperidone	low	1	0
sevoflurane	low	1	0
sulfadimethoxine	low	1	0
sulfisoxazole	low	1	0
thyroxine	low	2	0
aspartic acid	low	1	0
galactose	low	1	0
edetic acid	low	1	0
sodium citrate, anhydrous	low	1	0
mannitol	low	1	0
histidine	low	1	0
tryptophan	low	1	0
arginine	low	3	0
methylprednisolone	low	1	0
pregnenolone	low	1	0
isoxazoles	low	1	0
betamethasone	low	2	0
limestone	low	1	0
chenodeoxycholic acid	low	1	0
malondialdehyde	medium	7	1
fructosamine	low	1	0
zinc sulfate	medium	3	2
fludrocortisone	low	1	0
ursodeoxycholic acid	medium	6	1
glutamic acid	low	4	0
n-acetylaspartic acid	low	1	0
fibrinogen	low	1	0
homocysteine	low	1	0
levobupivacaine	low	1	0
5-pregnene-3,20-diol	low	1	0
glucuronic acid	low	1	0
u 73122	low	1	0
atazanavir sulfate	low	2	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
ritonavir	low	1	0
oxytocin	low	1	0
casein hydrolysate	low	1	0
estradiol-3-glucuronide	low	1	0
obeticholic acid	low	1	0
sodium bicarbonate	low	1	0
nitrogen dioxide	low	2	0
zinc protoporphyrin ix	low	2	0
bilirubin	medium	575	55
vitamin k semiquinone radical	low	1	0
cholecalciferol	medium	1	1
bilirubin diglucuronide	low	1	0
misoprostol	low	1	0
morphine	medium	4	2
lysophosphatidylcholines	low	1	0
biliverdine	low	1	0
aluminum	low	1	0
verlukast	low	1	0
gw 4064	low	1	0
lactulose	low	1	0
technetium tc 99m mebrofenin	low	1	0
losartan potassium	low	1	0
tin mesoporphyrin	medium	3	2
c-peptide	medium	1	1
phosphatidylcholines	low	1	0
sodium oxybate	low	2	0
heme	low	1	0
minocycline	low	1	0
rome	low	1	0
caseins	low	1	0
vitamin b 12	low	1	0
exudates	low	7	0
deoxyguanosine	low	1	0
folic acid	low	1	0
ganciclovir	low	1	0
olanzapine	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
lumirubin	medium	1	1
maltodextrin	medium	1	1

Protein Targets (734)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
RAR-related orphan receptor gamma	12	0	0	12
ATAD5 protein, partial	6	0	0	6
GLS protein	10	0	0	10
Microtubule-associated protein tau	9	0	0	9
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
thyroid stimulating hormone receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	11	0	0	11
EWS/FLI fusion protein	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	16	0	0	16
estrogen-related nuclear receptor alpha	20	0	0	20
estrogen nuclear receptor alpha	32	0	0	32
peroxisome proliferator activated receptor gamma	11	0	0	11
aryl hydrocarbon receptor	12	0	0	12
chromobox protein homolog 1	13	0	0	13
thyroid hormone receptor beta isoform 2	12	0	0	12
peripheral myelin protein 22	5	0	0	5
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	0	0	10
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	16	0	17
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Bile salt export pump	0	26	0	26
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	9
Carbonic anhydrase 2	0	5	0	10
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	2	0	3
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 3	0	2	0	4
Cytochrome P450 3A4	0	6	2	10
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	6	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	10	0	0	10
Sulfotransferase 1A1	0	0	0	2
Gamma-aminobutyric acid receptor subunit delta	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	0	10
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	6	2	1	9
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	0	10
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Carbonic anhydrase 4	0	4	0	6
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 6	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	0	10
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	2	0	4
Nuclear receptor ROR-gamma	4	0	0	4
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-2	10	0	0	10
Carbonic anhydrase 9	0	4	0	6
GABA theta subunit	10	0	0	10
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 15	0	2	0	4
Carbonic anhydrase 13	0	2	0	4
Gamma-aminobutyric acid receptor subunit epsilon	10	0	0	10
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	5
toxin B	0	0	0	1
thioredoxin reductase	13	0	0	13
TDP1 protein	20	0	0	20
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Bloom syndrome protein isoform 1	8	0	0	8
D(1A) dopamine receptor	1	0	0	1
lamin isoform A-delta10	16	0	0	16
neuropeptide S receptor isoform A	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	3	0	0	3
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	6	0	0	6
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	4	0	0	4
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	3	0	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Ferritin light chain	9	0	0	9
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	2	9
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	9
Glutamate receptor ionotropic, NMDA 2B	0	5	2	9
Glutamate receptor ionotropic, NMDA 2C	0	5	2	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	5	2	9
Glutamate receptor ionotropic, NMDA 3B	0	5	2	9
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	5	2	9
acetylcholinesterase	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
Cellular tumor antigen p53	20	0	0	20
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Spike glycoprotein	5	0	0	5
pregnane X receptor	4	0	0	4
GLI family zinc finger 3	17	0	0	17
AR protein	26	0	0	26
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	16	0	0	16
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	15	0	0	15
IDH1	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	10	3	18
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, Cruzipain	7	0	0	7
USP1 protein, partial	10	0	0	10
vitamin D3 receptor isoform VDRA	8	0	0	8
DNA polymerase kappa isoform 1	9	0	0	9
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	6	0	9
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Luciferase	7	0	0	7
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
peroxisome proliferator-activated receptor delta	11	0	0	11
caspase-3	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Alpha-2A adrenergic receptor	0	4	3	7
Vitamin D3 receptor	0	4	3	9
Alpha-2B adrenergic receptor	0	4	2	6
Alpha-2C adrenergic receptor	0	4	2	6
Retinoic acid receptor RXR-alpha	0	0	1	1
Guanine nucleotide-binding protein G	3	0	0	3
Ileal sodium/bile acid cotransporter	0	2	0	2
TAR DNA-binding protein 43	6	0	0	6
Bile acid receptor	0	0	2	2
G-protein coupled bile acid receptor 1	0	0	3	3
Bile acid receptor	0	2	4	7
interleukin 8	4	0	0	4
15-lipoxygenase, partial	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	17	0	0	17
survival motor neuron protein isoform d	6	0	0	6
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glycine receptor subunit alpha-1	0	0	3	3
Vitamin D3 receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	3	0	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	5	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Chain A, Beta-lactamase	5	0	0	5
Fumarate hydratase	3	0	0	3
GALC protein	3	0	0	3
regulator of G-protein signaling 4	5	0	0	5
polyprotein	3	0	0	3
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
M-phase phosphoprotein 8	5	0	0	5
5-hydroxytryptamine receptor 4	0	6	2	8
Fatty acid-binding protein, liver	0	5	2	7
Muscarinic acetylcholine receptor M1	0	1	2	3
Muscarinic acetylcholine receptor M3	0	1	2	3
Muscarinic acetylcholine receptor M4	0	1	2	3
Muscarinic acetylcholine receptor M5	0	1	2	3
Muscarinic acetylcholine receptor M2	0	1	2	3
Peroxisome proliferator-activated receptor alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	1	4	5
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor alpha	0	1	2	3
endonuclease IV	3	0	0	3
dopamine D1 receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	2	0	0	2
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	4	0	4
67.9K protein	4	0	0	4
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
Histone H2A.x	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	5	0	0	5
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
nonstructural protein 1	3	0	0	3
G	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Fatty acid-binding protein, liver	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Fatty acid-binding protein, intestinal	0	3	1	4
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	5	0	5
Sodium-dependent noradrenaline transporter	0	3	0	3
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	6	0	6
D(3) dopamine receptor	0	7	0	7
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Alpha-1A adrenergic receptor	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Inositol hexakisphosphate kinase 1	5	0	0	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
cytochrome P450 2C9, partial	5	0	0	5
glp-1 receptor, partial	4	0	0	4
PPM1D protein	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
Acid-sensing ion channel 3	0	2	0	2
Albumin	0	3	3	8
UDP-glucuronosyltransferase 2B7	0	0	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Acid-sensing ion channel 1	0	2	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Solute carrier family 22 member 6	0	3	0	4
Prostaglandin G/H synthase 1	0	2	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	2	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A1	0	2	0	3
Adenosine receptor A2a	0	1	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
muscleblind-like protein 1 isoform 1	2	0	0	2
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Epidermal growth factor receptor	0	1	0	1
Albumin	0	1	0	1
Albumin	0	0	2	2
Cholinesterase	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	2	0	2
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	4	1	8
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	5
D(2) dopamine receptor	0	5	0	5
Cytochrome P450 2B6	0	1	1	2
D(4) dopamine receptor	0	4	0	4
Mu-type opioid receptor	0	6	1	8
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	5	1	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	2	2
Aldehyde oxidase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Androgen receptor	0	3	0	3
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Stromelysin-1	0	2	1	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
thioredoxin glutathione reductase	4	0	0	4
cytochrome P450 2D6	3	0	0	3
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Acyl-CoA desaturase 1	0	1	0	1
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	3	0	3
5-hydroxytryptamine receptor 1A	0	2	3	5
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M5	0	3	0	3
Muscarinic acetylcholine receptor M1	0	2	1	3
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Angiotensin-converting enzyme	0	3	0	3
5-hydroxytryptamine receptor 2A	0	4	0	4
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	4	0	4
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H1 receptor	0	2	1	3
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H1 receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 6	0	5	0	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	3	0	3
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	4	1	5
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	2	0	2
Protease	0	1	1	4
Plasmepsin V	0	1	0	1
Protease	0	2	1	3
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Endothelin-1 receptor	0	2	0	2
Endothelin-1 receptor	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Direct Hyperbilirubinemia, Neonatal

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (657)

Protein Targets (734)

Direct Hyperbilirubinemia, Neonatal

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (657)

Drugs Studied (113)

Protein Targets (734)