Diabetes Mellitus, Lipoatrophic

A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).

Synonym
Diabetes Mellitus, Lipoatrophic
Lipoatrophic Diabetes

Excerpt	Reference
"Lipoatrophic diabetes is associated with abnormal central endocrine function but appropriate peripheral target gland secretion."	( Chopra, IJ; Soler, NG; Wortsman, J, 1982)
"Lipoatrophic diabetes mellitus is a rare insulin-resistance syndrome."	( Morse, AN; Whitaker, MD, 2000)
"Lipoatrophic diabetes is caused by a deficiency of adipose tissue and is characterized by severe insulin resistance, hypoleptinemia, and hyperphagia."	( Aizawa-Abe, M; Ebihara, K; Gavrilova, O; Hayashi, T; Hosoda, K; Inoue, G; Masuzaki, H; Miyanaga, F; Nakao, K; Ogawa, Y; Reitman, ML; Shintani, M; Yoshimasa, Y, 2001)
"Lipoatrophic diabetes is characterized by the near absence of adipose tissue and the presence of insulin-resistant diabetes."	( Amâncio, RF; Maranhão, RC; Santomauro, AT; Wajchenberg, BL, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	21 (31.34)	23.3326
1990's	6 (8.96)	12.5806
2000's	34 (50.75)	18.1394
2010's	5 (7.46)	28.8240
2020's	1 (1.49)	9.53

Drug	Relationship Strength	Studies	Trials
glycerol	low	1	0
niacin	low	1	0
palmitic acid	low	1	0
clofibrate	low	1	0
fenofibrate	low	1	0
gemfibrozil	low	1	0
metformin	low	4	0
metyrapone	low	2	0
2,4-thiazolidinedione	low	1	0
tolbutamide	low	1	0
troglitazone	low	2	0
pirinixic acid	low	1	0
corticosterone	low	1	0
thyroxine	low	1	0
aldosterone	low	1	0
prednisone	low	1	0
serine	low	2	0
tyrosine	low	1	0
leucine	low	1	0
asparagine	low	1	0
pyrrolidonecarboxylic acid	low	1	0
thiazoles	low	2	0
fructosamine	low	1	0
cromolyn sodium	low	1	0
bromocriptine	low	1	0
bezafibrate	low	1	0
rosiglitazone	medium	4	1
deoxyglucose	low	1	0
glycogen	low	1	0
oleic acid	low	1	0
tacrolimus	low	1	0
propylthiouracil	low	1	0
emerin	low	2	0
glucagon	low	2	0
insulin detemir	low	1	0
c-peptide	low	1	0
calpain	low	1	0
insulin, isophane	low	1	0
insulin glargine	low	2	0
leptin	low	19	0

Protein Targets (433)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Maltase-glucoamylase, intestinal	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
AR protein	16	0	0	16
glucocorticoid receptor [Homo sapiens]	12	0	0	12
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
geminin	10	0	0	10
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	1	3	4
Androgen receptor	0	4	0	4
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Carbonic anhydrase 1	0	0	0	2
Carbonic anhydrase 2	0	2	0	4
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	2	0	2
Luciferase	6	0	0	6
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	5	0	0	5
RAR-related orphan receptor gamma	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	20	0	0	20
G	9	0	0	9
peroxisome proliferator-activated receptor delta	8	0	0	8
peroxisome proliferator activated receptor gamma	10	0	0	10
D(1A) dopamine receptor	2	0	0	2
chromobox protein homolog 1	8	0	0	8
flap endonuclease 1	1	0	0	1
survival motor neuron protein isoform d	5	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	0	2	2
Glutamate receptor ionotropic, NMDA 3B	0	0	2	2
Bile salt export pump	0	4	0	4
5-hydroxytryptamine receptor 4	0	4	3	7
Bile salt export pump	0	12	0	12
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Fatty acid-binding protein, liver	0	5	2	7
Muscarinic acetylcholine receptor M1	0	0	6	6
Muscarinic acetylcholine receptor M3	0	0	6	6
Muscarinic acetylcholine receptor M4	0	0	6	6
Muscarinic acetylcholine receptor M5	0	0	6	6
Muscarinic acetylcholine receptor M2	0	0	6	6
Fatty acid-binding protein, intestinal	0	3	1	4
Peroxisome proliferator-activated receptor alpha	0	2	5	7
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	6	11	19
Peroxisome proliferator-activated receptor gamma	0	0	6	6
Peroxisome proliferator-activated receptor delta	0	2	3	6
Glutamate receptor ionotropic, NMDA 1	0	0	2	2
Peroxisome proliferator-activated receptor alpha	2	5	9	17
Glutamate receptor ionotropic, NMDA 2A	0	0	2	2
Glutamate receptor ionotropic, NMDA 2B	0	0	2	2
Glutamate receptor ionotropic, NMDA 2C	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	0	2	2
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Genome polyprotein	0	1	1	2
dopamine D1 receptor	1	0	0	1
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	2	0	0	2
GLS protein	1	0	0	1
TDP1 protein	12	0	0	12
regulator of G-protein signaling 4	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
polyprotein	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
vitamin D3 receptor isoform VDRA	3	0	0	3
thyroid hormone receptor beta isoform 2	11	0	0	11
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Cellular tumor antigen p53	10	0	0	10
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	3	2	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
5-hydroxytryptamine receptor 1B	0	2	0	2
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	4	0	4
Alpha-synuclein	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
D(2) dopamine receptor	0	1	1	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Beta-lactamase	1	0	0	1
Chain A, Ferritin light chain	4	0	0	4
GALC protein	3	0	0	3
thyroid stimulating hormone receptor	5	0	0	5
EWS/FLI fusion protein	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	10
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Inositol monophosphatase 1	1	0	0	1
GABA theta subunit	6	0	0	6
Canalicular multispecific organic anion transporter 1	0	7	0	7
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
pregnane X receptor	2	0	0	2
NFKB1 protein, partial	1	0	0	1
GLI family zinc finger 3	9	0	0	9
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
progesterone receptor	5	0	0	5
nonstructural protein 1	2	0	0	2
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
heat shock protein beta-1	4	0	0	4
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
endonuclease IV	1	0	0	1
USP1 protein, partial	7	0	0	7
Microtubule-associated protein tau	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
arylsulfatase A	1	0	0	1
aryl hydrocarbon receptor	3	0	0	3
serine-protein kinase ATM isoform a	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Fatty acid-binding protein, liver	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Glutamate receptor 2	2	0	0	2
Acetylcholinesterase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Cruzipain	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	2	2
Alpha-1A adrenergic receptor	0	4	0	4
Histamine H2 receptor	3	0	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
interleukin 8	2	0	0	2
Smad3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Transthyretin	0	1	1	3
Cytochrome P450 2C8	0	2	1	3
Cannabinoid receptor 2	0	0	3	3
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
glp-1 receptor, partial	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Polyphenol oxidase 2	0	1	0	2
Amyloid-beta precursor protein	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
Cytochrome P450 2C9	0	4	2	6
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
DNA polymerase kappa isoform 1	4	0	0	4
peripheral myelin protein 22	5	0	0	5
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Trypsin	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	4	1	5
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	4	0	4
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein 5	0	3	1	4
Rap guanine nucleotide exchange factor 4	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
acetylcholinesterase	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Acetylcholinesterase	0	2	0	2
Toll-like receptor 2	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
Renin	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	4	4
Retinoic acid receptor RXR-beta	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Retinoic acid receptor RXR-gamma	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	0	1	1
Chloride channel isoform 1	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Cytochrome P450 3A5	0	1	1	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Catechol O-methyltransferase	0	0	1	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Amine oxidase [flavin-containing] B	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	0	1	2
C-C chemokine receptor type 2	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Mu-type opioid receptor	0	1	0	1
ATP-binding cassette sub-family C member 8	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	2	0	2
Sodium/bile acid cotransporter	0	1	0	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
lethal factor (plasmid)	2	0	0	2
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Spike glycoprotein	2	0	0	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Albumin	0	1	1	2
Albumin	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
cytochrome P450 2D6	1	0	0	1
Histone H2A.x	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Forkhead box protein M1	0	2	0	2
Mitogen-activated protein kinase 14	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Diabetes Mellitus, Lipoatrophic

Synonyms(2)

Research Excerpts

Overview

Research

Studies (67)

Protein Targets (433)

Diabetes Mellitus, Lipoatrophic

Synonyms(2)

Research Excerpts

Overview

Research

Studies (67)

Drugs Studied (51)

Protein Targets (433)