Deficiency, Protein S

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

Synonym
Deficiency, Protein S
Protein S Deficiency
Hereditary Thrombophilia Due To Protein S Deficiency

Excerpt	Reference
"Protein S deficiency is an autosomal dominant inherited disease."	( Gerdts, R; Gundersen, T; Odegaard, OR, 1993)
"Protein S deficiency is known to be of clinical significance in patients with deep venous thrombosis or pulmonary emboli and in these patients, treatment is long-term anticoagulation."	( Lagosky, S; Witten, CM, 1993)
"Protein S deficiency is a recognized risk factor for venous thrombosis."	( Bayliss, P; Beauchamp, NJ; Cooper, PC; Daly, ME; Hampton, KK; Leach, M; Makris, M; Miller, GJ; Peake, IR; Preston, FE, 2000)
"Protein S deficiency is an inherited cause of thrombophilia."	( Brown, R; Marron, C; McKay, D, 2006)
"Among these, protein S deficiency is a coagulation disorder associated with recurrent thromboembolic events."	( Aleksic, I; Dietrich, W; Jakob, H; Marggraf, G; Massoudy, P; Müller-Beissenhirtz, H; Thielmann, M, 2006)
"Congenital protein S deficiency is associated with an increased risk of venous thrombosis."	( Dalbasti, T; Oktar, N, 2008)
"Protein S deficiency is strongly correlated to the occurrence of stent thrombosis, a fact that has hitherto not been recognized and needs further evaluation."	( Batra, A; Goel, PK, 2010)
"Postvaricella protein S deficiency is a rare and severe disease."	( De Geyer, A; Fraisse, B; Lucas, G; Marleix, S; Robert, G; Tattevin, P; Violas, P, 2018)
": Hereditary protein S deficiency is an autosomal dominant disorder associated with a high risk of venous thromboembolism (VTE) and usually results from mutations of PROS1."	( Ke, X; Liu, Z; Lou, J; Xu, F; Yin, L; Zhang, L, 2020)
"Hence, even though protein S deficiency is the rare cause of deep vein thrombosis when recurrent should be considered despite its rare occurrence."	( Awal, S; Dhakal, B; Neupane, S; Pudasaini, P; Subedi, B; Thapa, S, 2022)

Excerpt	Reference
"Protein S deficiency has been found to be associated with cerebrovascular occlusion and may possibly warrant long-term anticoagulation in these patients as well."	( Lagosky, S; Witten, CM, 1993)
"Inherited protein S deficiency has been associated with an increased risk of thromboembolic disease."	( Gill, JC; Konkol, RJ; Rich, C; Wernick, S, 1993)
"However, protein S deficiency has not been addressed in this manner."	( O'Brien, AE; Shiach, C; Tate, GM, 1998)

Excerpt	Reference
"All 25 patients developed protein S deficiency during estrogen treatment, which in most girls lasted for 4 weeks after cessation of estrogen administration."	( Delemarre-Van De Waal, HA; Fijnvandraat, K; Peters, M; van Ommen, CH; Vulsma, T, 1999)
"Thrombophilic familial protein S deficiency is known to be amplified by estrogen replacement therapy."	( Cameron, D; Glueck, CJ; Phillips, HG; Wang, P, 2001)
"We present a case of protein S deficiency causing central retinal vein occlusion treated with anticoagulation, which includes heparin followed by oral warfarin therapy."	( Barampouti, F; Yap, YC, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	72 (33.80)	12.5806
2000's	83 (38.97)	18.1394
2010's	49 (23.00)	28.8240
2020's	9 (4.23)	9.53

Drug	Relationship Strength	Studies	Trials
coumarin	low	3	0
cytosine	low	1	0
glycine	low	1	0
dalteparin	low	10	0
aspirin	medium	10	1
bupivacaine	low	1	0
fentanyl	low	1	0
isoflurane	low	1	0
khellin	low	1	0
phenindione	low	1	0
tranexamic acid	low	1	0
prednisolone	low	3	0
thymidine	low	1	0
prednisone	low	5	0
alanine	low	1	0
serine	low	1	0
aspartic acid	low	1	0
glutamine	low	1	0
ethinyl estradiol	low	4	0
tyrosine	low	1	0
leucine	low	1	0
methionine	low	1	0
cytarabine	low	1	0
threonine	low	1	0
arginine	low	5	0
methylprednisolone	low	2	0
thiophenes	low	4	0
thiazoles	low	1	0
chlormadinone acetate	low	1	0
homocystine	low	3	0
hesperidin	low	1	0
dimenhydrinate	low	1	0
gadolinium	low	1	0
levamisole	low	1	0
danazol	low	2	0
daunorubicin	low	1	0
ribavirin	low	1	0
desogestrel	low	2	0
atracurium	low	1	0
castanospermine	low	1	0
tirofiban	low	1	0
oseltamivir	low	1	0
fibrinogen	low	1	0
homocysteine	low	12	0
mci 9038	low	1	0
beta-lactams	low	1	0
proline	low	2	0
docetaxel anhydrous	low	1	0
ertapenem	low	1	0
dabigatran	low	2	0
carboplatin	low	1	0
fibrin	low	3	0
cocaine	low	1	0
thioguanine anhydrous	low	1	0
thiopental	low	1	0
vitamin k semiquinone radical	low	7	0
alprostadil	low	1	0
diosmin	low	1	0
fondaparinux	low	1	0
indinavir sulfate	low	1	0
cysteine	low	2	0
gadolinium dtpa	low	1	0
rivaroxaban	low	11	0
s 5682	low	1	0
apixaban	low	3	0
edoxaban	low	1	0
epoxomicin	low	1	0
losartan potassium	low	2	0
glucagon	low	1	0
dicumarol	medium	3	1
acenocoumarol	low	3	0
warfarin	low	73	0
phenprocoumon	low	3	0
epidermal growth factor	low	4	0
phytoestrogens	low	1	0
thromboplastin	low	8	0
guanosine	low	1	0
folic acid	low	1	0

Protein Targets (743)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Luciferase	8	0	0	8
RAR-related orphan receptor gamma	16	0	0	16
retinoid X nuclear receptor alpha	9	0	0	9
G	12	0	0	12
peroxisome proliferator activated receptor gamma	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
thyroid stimulating hormone receptor	7	0	0	7
chromobox protein homolog 1	8	0	0	8
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
geminin	17	0	0	17
muscleblind-like protein 1 isoform 1	4	0	0	4
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Guanine nucleotide-binding protein G	1	0	0	1
Inositol hexakisphosphate kinase 1	12	0	0	12
cytochrome P450 2C9, partial	12	0	0	12
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Carbonic anhydrase 1	0	3	0	8
Carbonic anhydrase 2	0	3	0	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	1	8
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
TDP1 protein	14	0	0	14
AR protein	22	0	0	22
glucocorticoid receptor [Homo sapiens]	20	0	0	20
estrogen nuclear receptor alpha	24	0	0	24
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Bile salt export pump	0	21	0	21
Cellular tumor antigen p53	19	0	0	19
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	14	0	14
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	10	0	0	10
Coagulation factor X	0	1	0	1
Prothrombin	0	6	1	7
Coagulation factor X	0	10	0	10
Trypsin-1	0	3	0	3
Trypsin-2	0	3	0	3
Trypsin-3	0	3	0	3
Spike glycoprotein	8	0	1	9
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	6	0	0	6
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	1	0	0	1
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	6	0	0	6
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	6	0	0	6
Cytochrome P450 3A4	0	5	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, Ferritin light chain	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	4	0	0	4
lamin isoform A-delta10	12	0	0	12
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	6
Glutamate receptor ionotropic, NMDA 2B	0	4	1	6
Glutamate receptor ionotropic, NMDA 2C	0	4	1	6
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	1	6
Glutamate receptor ionotropic, NMDA 3B	0	4	1	6
Glutamate receptor ionotropic, NMDA 3A	0	4	1	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
estrogen-related nuclear receptor alpha	17	0	0	17
cytochrome P450 2D6	9	0	0	9
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	5	0	0	5
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	2	1	8
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	2	1	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	1	0	2
Adenosine receptor A2a	0	1	0	2
Substance-P receptor	0	2	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	0	9
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	1	1	2
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	1	2
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
USP1 protein, partial	13	0	0	13
thyroid hormone receptor beta isoform 2	13	0	0	13
Lactoperoxidase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
acetylcholinesterase	6	0	0	6
estrogen receptor 2 (ER beta)	7	0	0	7
vitamin D3 receptor isoform VDRA	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
histone acetyltransferase KAT2A isoform 1	8	0	0	8
ATAD5 protein, partial	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
lysosomal alpha-glucosidase preproprotein	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
mitogen-activated protein kinase 1	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Toll-like receptor 4	0	1	0	1
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 1	0	3	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Amyloid-beta precursor protein	0	2	0	2
Beta-2 adrenergic receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	8	0	8
ATP-dependent translocase ABCB1	0	5	0	7
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	6	0	6
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Angiotensin-converting enzyme	0	3	0	3
Beta-3 adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	3
D(1A) dopamine receptor	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	3	0	4
Sodium-dependent noradrenaline transporter	0	10	0	10
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	0	3
Sodium-dependent serotonin transporter	0	8	0	8
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	4	0	4
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Potassium channel subfamily K member 10	0	1	0	1
Sodium-dependent dopamine transporter	0	10	0	10
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Cytochrome P450 1B1	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 1	0	5	0	5
Ataxin-2	8	0	0	8
TAR DNA-binding protein 43	2	0	0	2
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Non-lysosomal glucosylceramidase	0	1	0	1
Chain A, Cruzipain	1	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	15	0	0	15
thioredoxin glutathione reductase	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
progesterone receptor	9	0	0	9
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Glucocorticoid receptor	0	12	2	19
Glycine receptor subunit alpha-1	0	12	0	12
Androgen receptor	0	9	0	9
Glutamate receptor 2	10	0	0	10
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Cytochrome P450 2C19	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
pregnane X receptor	4	0	0	4
GALC protein	2	0	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	3
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	1	0	2
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	1	0	2
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	1	0	3
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
endonuclease IV	2	0	0	2
glp-1 receptor, partial	4	0	0	4
67.9K protein	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	2
Histone H2A.x	8	0	0	8
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	1	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Plasminogen	0	4	1	5
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Multidrug and toxin extrusion protein 2	0	3	0	3
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
heat shock protein beta-1	4	0	0	4
Rap guanine nucleotide exchange factor 3	3	0	0	3
Estrogen receptor	0	6	1	7
Sex hormone-binding globulin	0	0	3	3
Cytochrome P450 1A2	0	3	0	3
Adenosine receptor A3	0	7	0	7
Cytochrome P450 2C9	0	6	0	6
Alpha-1B adrenergic receptor	0	7	0	7
Muscarinic acetylcholine receptor M3	0	4	0	4
Substance-K receptor	0	4	0	4
Mu-type opioid receptor	0	6	1	7
Kappa-type opioid receptor	0	6	0	6
Alpha-1A adrenergic receptor	0	7	0	7
Cytochrome P450 2J2	0	3	0	3
ATPase family AAA domain-containing protein 5	5	0	0	5
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
PPM1D protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
aryl hydrocarbon receptor	5	0	0	5
Caspase-7	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
huntingtin isoform 2	1	0	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	2	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	6	2	0	8
Carbonyl reductase [NADPH] 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	6	2	0	8
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	6	2	0	8
Platelet-activating factor receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	6	2	0	8
Multidrug resistance-associated protein 1	0	2	0	3
Histamine H2 receptor	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-2	6	2	0	8
Inositol monophosphatase 1	2	0	0	2
Histone deacetylase 1	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
GABA theta subunit	6	2	0	8
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	6	2	0	8
Histone deacetylase 6	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Integrase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Cytochrome P450 2D6	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Histamine H1 receptor	0	3	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Lysine-specific histone demethylase 1A	0	2	0	2
Aurora kinase B	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Cathepsin B	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Cathepsin S	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vpr	1	0	0	1
Cytochrome P450 2B1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
Adenosine receptor A2a	0	3	0	3
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	3	1	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Purine nucleoside phosphorylase	0	0	0	1
Adenosylhomocysteinase	0	1	0	4
Neuraminidase	0	3	0	3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Calmodulin-1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Nischarin	0	1	0	1
Substance-K receptor	0	1	0	1
Heparanase	0	0	1	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Albumin	0	0	1	3
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Gag-Pol polyprotein	0	3	0	3
Alpha-1D adrenergic receptor	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Genome polyprotein	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Protease	0	5	1	8
Protease	0	2	1	3
Protease	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
dopamine D1 receptor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Smad3	2	0	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Prothrombin	0	1	0	1
Cationic trypsin	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
nonstructural protein 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Neuraminidase	0	2	0	2
Sialidase	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
NS5	0	0	1	1
Thrombopoietin	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
PAX8	0	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
hemoglobin subunit beta	1	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Apoptosis regulator Bcl-2	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Mitogen-activated protein kinase 3	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Integrin subunit alpha 2b	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	1	0	1
Integrin alpha-5	0	1	0	1
Integrin beta-3	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Urokinase-type plasminogen activator	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Albumin	0	0	1	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (213)

Protein Targets (743)

Deficiency, Protein S

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (213)

Drugs Studied (90)

Protein Targets (743)