Page last updated: 2024-09-27

De Morsier Syndrome

A condition resulting from congenital malformations involving the brain. The syndrome of septo-optic dysplasia combines hypoplasia or agenesis of the SEPTUM PELLUCIDUM; CORPUS CALLOSUM and the OPTIC NERVE. The extent of the abnormalities can vary. Septo-optic dysplasia is often associated with abnormalities of the HYPOTHALAMUS and other diencephalic structures, and HYPOPITUITARISM.

Synonyms(4)

Synonym
Septooptic Dysplasia
Septo-Optic Dysplasia
Septo-Optic Dysplasia with Growth Hormone Deficiency
De Morsier Syndrome

Research Excerpts

Research

Studies (25)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's12 (48.00)18.1394
2010's11 (44.00)28.8240
2020's2 (8.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3-hydroxybutyric acid0low10
melatonin0medium11
carbamazepine0low10
valproic acid0low20
sevoflurane0low10
thyroxine0low10
arginine0low10
propiconazole0low10
remifentanil0low10
inositol 3-phosphate0low10
arginine vasopressin0low20
leukotriene e40low10
deamino arginine vasopressin0low10
cysteine0low10
pituitrin0low10
hes1 protein, human0low70
glucagon0low10
c-peptide0low10
piperidines0low10
olanzapine0low10

Protein Targets (296)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase3003
phosphopantetheinyl transferase3003
NFKB1 protein, partial1001
GLS protein2002
thyroid stimulating hormone receptor2002
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 24004
cytochrome P450 2C19 precursor1001
chromobox protein homolog 13003
flap endonuclease 11001
DNA polymerase iota isoform a (long)2002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Cytochrome P450 3A40203
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase2002
vitamin D3 receptor isoform VDRA3003
peripheral myelin protein 221001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0505
Translocator protein0011
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0022
Vasopressin V1a receptor0224
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0101
Vasopressin V2 receptor 0224
Canalicular multispecific organic anion transporter 10404
Chain A, Beta-lactamase2002
acetylcholinesterase1001
RAR-related orphan receptor gamma4004
USP1 protein, partial2002
TDP1 protein4004
AR protein3003
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 14004
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha5005
IDH11001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 21001
mitogen-activated protein kinase 12002
geminin3003
Vpr1001
lamin isoform A-delta104004
Bile salt export pump0202
Albumin0011
Major prion protein0011
Cellular tumor antigen p536006
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0101
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20101
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
histone acetyltransferase KAT2A isoform 11001
Canalicular multispecific organic anion transporter 10101
P2Y purinoceptor 120011
Cysteinyl leukotriene receptor 20011
Cysteinyl leukotriene receptor 10011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
interleukin 81001
ClpP1001
ATAD5 protein, partial1001
GLI family zinc finger 33003
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A11001
nuclear receptor subfamily 1, group I, member 35005
regulator of G-protein signaling 41001
EWS/FLI fusion protein2002
caspase-31001
aryl hydrocarbon receptor4004
Bloom syndrome protein isoform 11001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
ras-related protein Rab-9A1001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
Gamma-aminobutyric acid receptor subunit pi1001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cholinesterase0101
Cytochrome P450 2C11 0101
Cytochrome P450 2D60101
Aromatase0101
Gamma-aminobutyric acid receptor subunit beta-11001
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Acetylcholinesterase0101
Metabotropic glutamate receptor 10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Acetylcholinesterase 0101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Mu-type opioid receptor0202
Nociceptin receptor0101
Alpha-1A adrenergic receptor0202
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
5-hydroxytryptamine receptor 3E0101
peroxisome proliferator-activated receptor delta3003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
lysosomal alpha-glucosidase preproprotein1001
thyroid hormone receptor beta isoform 23003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 40202
5-hydroxytryptamine receptor 3B0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10001
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M10112
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0101
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
Alpha-2B adrenergic receptor0101
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent noradrenaline transporter 0101
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
Histamine H1 receptor0213
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein2002
D(2) dopamine receptor0202
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Sigma non-opioid intracellular receptor 10303
Transporter0101
Nuclear receptor subfamily 3 group C member 3 0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Transporter0101
Chain A, Ferritin light chain1001
glp-1 receptor, partial1001
pregnane X receptor2002
SMAD family member 21001
SMAD family member 31001
estrogen receptor 2 (ER beta)1001
progesterone receptor1001
nonstructural protein 11001
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor2002
peroxisome proliferator activated receptor gamma3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
nuclear factor erythroid 2-related factor 2 isoform 13003
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent calcium channel gamma-2 subunit1001
Glutamate receptor 21001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
heat shock protein 90, putative0001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
cytochrome P450 family 3 subfamily A polypeptide 41001
G1001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
cytochrome P450 2C9, partial1001
Luciferase1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]