Page last updated: 2024-09-27

Cranial Nerve IV Diseases

Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.

Synonyms(11)

Synonym
Trochlear Nerve Palsy
Superior Oblique Palsy, Neurogenic
Fourth Cranial Nerve Diseases
Trochlear Nerve Diseases
Trochlear Nerve Disorders
Fourth Cranial Nerve Palsy
Neurogenic Superior Oblique Palsy
Trochlear Neuropathy
Cranial Nerve IV Diseases
Superior Oblique Myokymia
Fourth Nerve Palsy

Research Excerpts

Overview

ExcerptReference
"Superior oblique myokymia is a relatively poorly known disorder, despite classic pathognomonic symptoms."( Defoort-Dhellemmes, S; Signolles, C; Thoorens, V, 2012)

Treatment

ExcerptReference
"Two adult patients with superior oblique myokymia, refractory to other therapies, were treated with gabapentin orally after informed consent was obtained."( Kosmorsky, GS; Leigh, RJ; Tomsak, RL, 2002)

Research

Studies (64)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (1.56)12.5806
2000's22 (34.38)18.1394
2010's31 (48.44)28.8240
2020's10 (15.63)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium41
phenytoin0low10
apraclonidine0low10
aspirin0low20
bupivacaine0low10
carbamazepine0low30
clonidine0low10
valproic acid0low10
foscarnet0low10
gabapentin0medium41
indomethacin0low20
2-propanol0low10
propranolol0low10
succinylcholine0low10
prednisolone0low40
prednisone0low20
triamcinolone acetonide0low10
methylprednisolone0low20
pyridostigmine bromide0low10
galantamine0low10
gadolinium0low20
phenyl acetate0medium21
carticaine0low10
timolol0low10
etoposide0low10
levobunolol0low10
propiconazole0low140
cabergoline0low10
oseltamivir0low10
methotrexate0low10
atropine0low10
carboplatin0low10
rocuronium0low10
tretinoin0low10
clindamycin0low10
cannabidiol0low10
ergoline0low10
ro13-99040low10
acyclovir0low40
sildenafil citrate0low10
eye0low70
gq1b ganglioside0low10

Protein Targets (695)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit8008
RAR-related orphan receptor gamma120012
GLI family zinc finger 3120012
AR protein190019
aldehyde dehydrogenase 1 family, member A18008
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha100010
estrogen nuclear receptor alpha180018
peroxisome proliferator-activated receptor delta9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x5005
thyroid hormone receptor beta isoform a8008
heat shock protein beta-16006
nuclear factor erythroid 2-related factor 2 isoform 1110011
lamin isoform A-delta10160016
Voltage-dependent calcium channel gamma-2 subunit8008
Glutamate receptor 28008
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain6006
Thymidine kinase 0101
thioredoxin reductase100010
phosphopantetheinyl transferase7007
GLS protein5005
TDP1 protein130013
Smad32002
thyroid stimulating hormone receptor8008
EWS/FLI fusion protein6006
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2160016
Bloom syndrome protein isoform 17007
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Solute carrier family 22 member 1 0406
ATP-binding cassette sub-family C member 3017017
Multidrug resistance-associated protein 4017019
Solute carrier family 22 member 60304
Bile salt export pump0505
Bile salt export pump021021
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0718
Cytochrome P450 2J20404
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60204
Thymidine kinase 0101
Solute carrier family 22 member 80204
Canalicular multispecific organic anion transporter 1018019
Thymidine kinase0101
Chain A, Beta-lactamase6006
Luciferase5005
glp-1 receptor, partial3003
ATAD5 protein, partial4004
Fumarate hydratase1001
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 3110011
progesterone receptor100010
glucocorticoid receptor [Homo sapiens]170017
estrogen-related nuclear receptor alpha160016
farnesoid X nuclear receptor6006
pregnane X nuclear receptor130013
polyprotein1001
67.9K protein4004
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
caspase-32002
IDH16006
aryl hydrocarbon receptor6006
nuclear receptor subfamily 1, group I, member 25005
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
chromobox protein homolog 19009
nuclear factor erythroid 2-related factor 2 isoform 29009
transcriptional regulator ERG isoform 34004
thyroid hormone receptor beta isoform 28008
histone deacetylase 9 isoform 31001
mitogen-activated protein kinase 12002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin100010
Vif0001
peripheral myelin protein 226006
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A3003
Interferon beta9009
Cellular tumor antigen p53120012
Integrin beta-32103
Integrin alpha-IIb2103
Methionine aminopeptidase0101
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 13003
ATPase family AAA domain-containing protein 59009
Ataxin-2100010
NFKB1 protein, partial3003
regulator of G-protein signaling 47007
muscarinic acetylcholine receptor M17007
Alpha-2A adrenergic receptor05410
Alpha-2B adrenergic receptor0438
Alpha-2C adrenergic receptor06411
Alpha-2B adrenergic receptor0314
Alpha-1D adrenergic receptor0539
Adenosine receptor A2b0022
Adenosine receptor A2a0224
Alpha-1A adrenergic receptor0348
Alpha-1B adrenergic receptor0236
ATP-dependent phosphofructokinase8008
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase5005
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 48008
cytochrome P450 2D68008
glucocerebrosidase2002
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase iota isoform a (long)6006
DNA polymerase kappa isoform 15005
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0202
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0203
Epidermal growth factor receptor0202
Carbonic anhydrase 10305
Carbonic anhydrase 20416
Fatty acid-binding protein, liver0202
Myeloperoxidase0101
Prostaglandin G/H synthase 10304
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10202
Substance-P receptor0202
Prostaglandin G/H synthase 20516
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma4116
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-125310
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 40404
Muscarinic acetylcholine receptor M20328
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10328
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30327
5-hydroxytryptamine receptor 2C0516
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor4005
5-hydroxytryptamine receptor 70303
Reverse transcriptase/RNaseH 0113
Muscarinic acetylcholine receptor0112
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
acetylcholinesterase7007
thyroid stimulating hormone receptor3003
5-hydroxytryptamine receptor 2B0527
Spike glycoprotein7007
Histamine H3 receptor0202
PPM1D protein2002
Acetylcholinesterase0303
L-lactate dehydrogenase A chain0101
Cytochrome P450 1A10101
Cytochrome P450 1A20213
Cytochrome P450 2C11 0101
Cytochrome P450 3A40516
5-hydroxytryptamine receptor 1A0213
Cytochrome P450 2D60314
Cytochrome P450 2A60202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Fatty acid-binding protein, liver0101
5-hydroxytryptamine receptor 2A0112
Cannabinoid receptor 10101
Cytochrome P450 2B60112
Cytochrome P450 3A50101
Cannabinoid receptor 10102
D(1A) dopamine receptor0213
Cytochrome P450 3A70101
Caspase-10012
Cytochrome P450 2C190213
Cannabinoid receptor 2 0113
Mu-type opioid receptor0213
Peroxisome proliferator-activated receptor gamma0022
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Cholinesterase0303
N-acylethanolamine-hydrolyzing acid amidase0101
Cytochrome P450 1B10101
Heat sensitive channel TRPV30112
Sigma intracellular receptor 20101
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily V member 10112
Transient receptor potential cation channel subfamily M member 80101
Transient receptor potential cation channel subfamily V member 40112
Transient receptor potential cation channel subfamily V member 20112
G-protein coupled receptor 550011
Diacylglycerol lipase-alpha0101
USP1 protein, partial5005
Vpr1001
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70103
Sodium channel protein type 4 subunit alpha0204
Potassium voltage-gated channel subfamily H member 20404
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
estrogen receptor 2 (ER beta)7007
G6006
vitamin D3 receptor isoform VDRA8008
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
histone acetyltransferase KAT2A isoform 15005
HLA class I histocompatibility antigen, B alpha chain 6006
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
Chain A, JmjC domain-containing histone demethylation protein 3A1001
apical membrane antigen 1, AMA11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Solute carrier family 15 member 10101
Solute carrier family 22 member 110102
Solute carrier family 22 member 80101
Protein-arginine deiminase type-40202
Chain A, Cruzipain3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
Beta-1 adrenergic receptor 0135
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 13003
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor3003
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30202
Alpha-1B adrenergic receptor0415
Alpha-1A adrenergic receptor0112
D0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A010213
Amine oxidase [flavin-containing] A0101
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Alpha-1D adrenergic receptor0314
D(1B) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
5-hydroxytryptamine receptor 1B0808
Alpha-2B adrenergic receptor0001
D(4) dopamine receptor0101
Delta-type opioid receptor0202
Alpha-1A adrenergic receptor0426
D(2) dopamine receptor0101
Mu-type opioid receptor0101
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10202
Nischarin0101
SMAD family member 24004
SMAD family member 34004
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
transactivating tegument protein VP16 [Human herpesvirus 1]0202
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10608
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30405
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0101
Carbonic anhydrase 40102
DNA polymerase delta catalytic subunit0101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 90102
thioredoxin glutathione reductase3003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, ACETYLCHOLINESTERASE0101
Chain A, Acetylcholinesterase0101
Acetylcholinesterase0202
Cholinesterase0202
Vascular endothelial growth factor receptor 1 0101
Acetylcholinesterase0202
Acetylcholinesterase0315
Acetylcholinesterase 0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Acetylcholinesterase0101
Kappa-type opioid receptor0101
Prolyl endopeptidase0101
Small conductance calcium-activated potassium channel protein 30101
Carboxylic ester hydrolase 0202
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B4004
D(1A) dopamine receptor3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi2428
Gamma-aminobutyric acid receptor subunit delta0202
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-12428
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit delta2428
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit gamma-22439
Gamma-aminobutyric acid receptor subunit alpha-52428
Gamma-aminobutyric acid receptor subunit alpha-32428
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit gamma-12428
Gamma-aminobutyric acid receptor subunit alpha-22428
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit alpha-42428
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit gamma-32428
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-62428
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50213
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit beta-10112
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-32428
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit beta-22439
Gamma-aminobutyric acid receptor subunit epsilon0202
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 434004
Histone deacetylase 10303
Gamma-aminobutyric acid receptor subunit alpha-60213
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0112
Histone deacetylase 70303
GABA theta subunit2428
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Gamma-aminobutyric acid receptor subunit gamma-30202
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit epsilon2428
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Gamma-aminobutyric acid receptor subunit theta0202
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, membrane-associated prostaglandin E synthase-20101
Microtubule-associated protein tau4004
Parkin2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
peripheral myelin protein 22 isoform 12002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear receptor ROR-gamma isoform 17007
M-phase phosphoprotein 84004
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Albumin0123
Procathepsin L0101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Thromboxane-A synthase 0101
Indoleamine 2,3-dioxygenase 10202
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Aldo-keto reductase family 1 member C30202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin G/H synthase 1 0101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
Beta-2 adrenergic receptor0617
Beta-1 adrenergic receptor0617
Beta-3 adrenergic receptor0617
Sodium-dependent serotonin transporter0404
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
flap endonuclease 12002
snurportin-11001
DNA polymerase eta isoform 11001
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Broad substrate specificity ATP-binding cassette transporter ABCG20001
nonstructural protein 13003
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Androgen receptor0303
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Nuclear receptor subfamily 1 group I member 20011
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0202
Neuraminidase0101
Neuraminidase0202
Sialidase0101
Acyl-CoA desaturase 10101
Liver carboxylesterase 10102
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0101
Neuraminidase0101
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
endonuclease IV2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Sodium channel protein type 1 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor4004
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
heat shock protein 90, putative0001
Adenosine receptor A30314
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
D(2) dopamine receptor0112
Beta-1 adrenergic receptor0315
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 60213
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0124
Nuclear receptor subfamily 2 group E member 10022
Histamine H4 receptor0101
potassium voltage-gated channel subfamily H member 2 isoform d2002
Carbonic anhydrase 120001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Carbonic anhydrase 30001
Carbonic anhydrase 60001
Carbonic anhydrase 70001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
cytochrome P450 3A4 isoform 12002
Chain A, Nuclear Receptor ROR-beta0101
thyrotropin-releasing hormone receptor1001
Caspase-71001
caspase-31001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Nuclear receptor ROR-alpha0101
Alpha-synuclein0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]