Page last updated: 2024-09-27

Cranial Nerve I Diseases

Diseases of the first cranial (olfactory) nerve, which usually feature anosmia or other alterations in the sense of smell and taste. Anosmia may be associated with NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; CRANIOCEREBRAL TRAUMA; inherited conditions; toxins; METABOLIC DISEASES; tobacco abuse; and other conditions. (Adams et al., Principles of Neurology, 6th ed, pp229-31)

Synonyms(4)

Synonym
First Cranial Nerve Diseases
Cranial Nerve I Disorders
Cranial Nerve I Diseases
Olfactory Nerve Diseases

Research

Studies (5)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (20.00)12.5806
2000's1 (20.00)18.1394
2010's3 (60.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
1-butanol0low10
sabinene0low10
gadolinium0low10
phenylephrine hydrochloride0low10
thallium-2010low10

Protein Targets (37)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
aldehyde dehydrogenase 1 family, member A11001
glucocorticoid receptor [Homo sapiens]2002
farnesoid X nuclear receptor1001
estrogen nuclear receptor alpha2002
Voltage-dependent calcium channel gamma-2 subunit1001
Cellular tumor antigen p532002
Glutamate receptor 21001
Choline O-acetyltransferase 0102
Chain A, 2-oxoglutarate Oxygenase1001
glp-1 receptor, partial1001
thioredoxin reductase1001
RAR-related orphan receptor gamma1001
GALC protein1001
TDP1 protein1001
GLI family zinc finger 31001
AR protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen-related nuclear receptor alpha1001
peroxisome proliferator activated receptor gamma1001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
thyroid stimulating hormone receptor1001
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 11001
geminin1001
Vpr1001
peripheral myelin protein 221001
lamin isoform A-delta101001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Spike glycoprotein1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]