Page last updated: 2024-09-27

Corneal Dystrophy, Juvenile Epithelial of Meesmann

An autosomal dominant form of hereditary corneal dystrophy due to a defect in cornea-specific KERATIN formation. Mutations in the genes that encode KERATIN-3 and KERATIN-12 have been linked to this disorder.

Synonyms(7)

Synonym
Corneal Dystrophy, Juvenile Epithelial of Meesmann
Meesmann Epithelial Corneal Dystrophy
Corneal Dystrophy, Meesmann Epithelial
Meesmann Corneal Epithelial Dystrophy
Corneal Dystrophy, Meesmann
Meesmann Corneal Dystrophy
Juvenile Hereditary Epithelial Dystrophy

Research

Studies (6)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's2 (33.33)18.1394
2010's3 (50.00)28.8240
2020's1 (16.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
mitomycin0low20
arginine0low10
fluorescein0low10
proline0low10
bromochloroacetic acid0low10
transforming growth factor beta0low10

Protein Targets (93)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase1001
phosphopantetheinyl transferase1001
NFKB1 protein, partial1001
GLS protein1001
thyroid stimulating hormone receptor1001
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 22002
cytochrome P450 2C19 precursor1001
chromobox protein homolog 11001
flap endonuclease 11001
DNA polymerase iota isoform a (long)2002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Cytochrome P450 3A40001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase1001
RAR-related orphan receptor gamma2002
AR protein3003
aldehyde dehydrogenase 1 family, member A11001
nuclear receptor subfamily 1, group I, member 32002
retinoic acid nuclear receptor alpha variant 13003
thyroid stimulating hormone receptor1001
nuclear factor erythroid 2-related factor 2 isoform 12002
Cellular tumor antigen p533003
Nuclear receptor ROR-gamma1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit2002
SMAD family member 21001
SMAD family member 31001
Microtubule-associated protein tau1001
estrogen receptor 2 (ER beta)2002
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]2002
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha2002
farnesoid X nuclear receptor2002
pregnane X nuclear receptor1001
estrogen nuclear receptor alpha2002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
aryl hydrocarbon receptor2002
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Bloom syndrome protein isoform 11001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-11001
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 11001
Fumarate hydratase1001
TDP1 protein1001
GLI family zinc finger 31001
caspase 7, apoptosis-related cysteine protease1001
cytochrome P450 family 3 subfamily A polypeptide 41001
EWS/FLI fusion protein1001
cytochrome P450 2D61001
polyprotein1001
67.9K protein1001
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x1001
nuclear factor erythroid 2-related factor 2 isoform 21001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin1001
Voltage-dependent calcium channel gamma-2 subunit1001
Indoleamine 2,3-dioxygenase 10101
Glutamate receptor 21001
Spike glycoprotein1001
lamin isoform A-delta101001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Glutamate receptor ionotropic, NMDA 1 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]