Page last updated: 2024-09-28

Cor Triatriatum

A malformation of the heart in which the embryonic common PULMONARY VEIN was not incorporated into the LEFT ATRIUM leaving behind a perforated fibromuscular membrane bisecting the left atrium, a three-atrium heart. The opening between the two left atrium sections determines the degree of obstruction to pulmonary venous return, pulmonary venous and pulmonary arterial hypertension.

Synonyms(4)

Synonym
Subdivided Left Atrium
Cor Triatriatum
Cor Triatriatum Sinistrum
Triatrial Heart

Research Excerpts

Overview

ExcerptReference
"Cor triatriatum is another rare congenital cardiac anomaly due to faulty incorporation of the common pulmonary vein into the left atrium."( Jayranganath, M; Manjunath, CN; Subramanian, A, 2011)

Research

Studies (13)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (7.69)23.3326
1990's2 (15.38)12.5806
2000's3 (23.08)18.1394
2010's7 (53.85)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aspirin0low10
enflurane0low10
fentanyl0low10
furosemide0low10
isoflurane0low10
propofol0low10
spironolactone0low10
technetium0low10
dobutamine0low10
levobupivacaine0low10
bosentan anhydrous0low10
methotrexate0low10
benazepril0low10
cardiovascular agents0low10
hyaluronoglucosaminidase0low20
eye0low10

Protein Targets (393)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
thioredoxin reductase3003
GLS protein3003
AR protein8008
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor3003
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 46006
EWS/FLI fusion protein5005
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha6006
estrogen nuclear receptor alpha8008
cytochrome P450 2D62002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH14004
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 24004
Bloom syndrome protein isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0606
Epidermal growth factor receptor0202
Carbonic anhydrase 10506
Carbonic anhydrase 20517
Fatty acid-binding protein, liver0101
Integrin beta-32103
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2114
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12215
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Canalicular multispecific organic anion transporter 10303
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10112
Fumarate hydratase2002
polyprotein2002
Angiotensin-converting enzyme 0101
Angiotensin-converting enzyme0101
Liver carboxylesterase 10001
Angiotensin-converting enzyme0101
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma6006
GLI family zinc finger 35005
estrogen receptor 2 (ER beta)6006
progesterone receptor5005
pregnane X nuclear receptor5005
G2002
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)3003
vitamin D3 receptor isoform VDRA2002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 15005
nuclear receptor ROR-gamma isoform 12002
Bile salt export pump0404
Nuclear receptor subfamily 1 group I member 20022
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Endothelin receptor type B0101
Endothelin receptor type B0213
Endothelin-1 receptor0202
Endothelin-1 receptor0213
Endothelin receptor type B0011
Deoxyhypusine synthase0101
Sodium/bile acid cotransporter0202
Endothelin-1 receptor0101
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, Beta-lactamase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
PAX80001
SMAD family member 22002
ATAD5 protein, partial2002
PPM1D protein1001
SMAD family member 32002
TDP1 protein5005
STAT3, partial0101
thioredoxin glutathione reductase1001
Smad32002
nuclear receptor subfamily 1, group I, member 33003
regulator of G-protein signaling 41001
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor5005
67.9K protein3003
alpha-galactosidase2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a2002
tumor necrosis factor1001
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 22002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
thyroid hormone receptor beta isoform 26006
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
geminin5005
lamin isoform A-delta104004
Solute carrier organic anion transporter family member 1A40102
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p536006
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10304
Cytochrome P450 3A40101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Glutamate receptor 23003
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 53003
Ataxin-24004
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30102
Solute carrier organic anion transporter family member 1B10101
dopamine D1 receptor2002
glp-1 receptor, partial2002
GALC protein1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
Histone H2A.x4004
D(1A) dopamine receptor2002
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 12002
huntingtin isoform 21001
5-hydroxytryptamine receptor 2A0011
Solute carrier family 22 member 1 0202
Carbonic anhydrase 120203
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30202
Beta-2 adrenergic receptor0202
Aldo-keto reductase family 1 member B10404
Beta-1 adrenergic receptor0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor0202
Carbonic anhydrase 40203
Carbonic anhydrase 60203
Sodium-dependent noradrenaline transporter 0404
Alpha-1D adrenergic receptor0202
Sodium-dependent serotonin transporter0202
Carbonic anhydrase 5A, mitochondrial0203
D(3) dopamine receptor0303
Carbonic anhydrase 70203
Spike glycoprotein5005
Sodium-dependent dopamine transporter 0202
Carbonic anhydrase 90203
Carbonic anhydrase 130101
Carbonic anhydrase 150101
Carbonic anhydrase 140203
Carbonic anhydrase 5B, mitochondrial0203
peripheral myelin protein 222002
Luciferase1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Kappa-type opioid receptor0202
Histamine H1 receptor0101
Mu-type opioid receptor0213
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20202
Sigma non-opioid intracellular receptor 10202
thyrotropin-releasing hormone receptor1001
Albumin0101
Glucose-6-phosphate 1-dehydrogenase0202
Cytochrome P450 2C9 0101
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0202
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Multidrug and toxin extrusion protein 10202
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
cytochrome P450 2D6 isoform 11001
cytochrome P450 3A4 isoform 12002
histone acetyltransferase KAT2A isoform 12002
Gamma-aminobutyric acid receptor subunit pi2114
Cytochrome P450 2D60101
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-22114
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
Inositol monophosphatase 11001
GABA theta subunit2114
Gamma-aminobutyric acid receptor subunit epsilon2114
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial1001
USP1 protein, partial2002
Microtubule-associated protein tau1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
survival motor neuron protein isoform d1001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
ATP-dependent phosphofructokinase1001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
caspase-31001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
pregnane X receptor1001
Vpr1001
Estrogen receptor0213
Glucocorticoid receptor0213
Progesterone receptor0213
Glycine receptor subunit alpha-10202
Mineralocorticoid receptor 0203
Androgen receptor0213
Androgen receptor0203
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Sodium-dependent serotonin transporter0101
Cytochrome P450 2C190101
Estrogen receptor beta0112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]