Benign Familial Infantile Convulsions

A condition marked by recurrent seizures that occur during the first 4-6 weeks of life despite an otherwise benign neonatal course. Autosomal dominant familial and sporadic forms have been identified. Seizures generally consist of brief episodes of tonic posturing and other movements, apnea, eye deviations, and blood pressure fluctuations. These tend to remit after the 6th week of life. The risk of developing epilepsy at an older age is moderately increased in the familial form of this disorder. (Neurologia 1996 Feb;11(2):51-5)

Synonym
Benign Familial Infantile Convulsions Syndrome
Benign Familial Neonatal Convulsions
Benign Familial Neonatal Epilepsy
Benign Familial Neonatal-Infantile Seizures
Benign Infantile Familial Convulsions
Benign Neonatal Convulsions
Benign Neonatal Epilepsy
Benign Neonatal Epilepsy, Nonfamilial
Benign Neonatal Non-Familial Convulsions
Benign Neonatal Nonfamilial Epilepsy
Benign Non-Familial Neonatal Convulsions
Familial Benign Neonatal Epilepsy
Familial Benign Neonatal Convulsions
Non-Familial Benign Neonatal Convulsions
Non-Familial Benign Neonatal Epilepsy
Epilepsy, Benign Neonatal
Epilepsy, Benign Neonatal-Infantile
Epilepsy, Benign Neonatal, Familial
Epilepsy, Benign Neonatal, Non-Familial
Seizures, Benign Familial Neonatal-Infantile
Seizures, Benign Familial Infantile, 3
Epilepsy, Benign Neonatal, Nonfamilial
Neonatal Convulsions, Benign
Convulsions, Benign Neonatal, Non-Familial
Seizures, Benign Familial Infantile, 1
Convulsions, Benign Neonatal, Familial
Convulsions, Benign Familial Infantile, 3
Convulsions, Benign Familial Infantile, 1
Convulsions Benign Familial Neonatal
Benign Familial Infantile Convulsions

Excerpt	Reference
"Benign familial neonatal convulsions is a rare idiopathic, generalized epilepsy syndrome."	( Cooper, EC; Jan, LY, 2003)
"Benign familial neonatal convulsions are a rare, autosomal-dominant form of neonatal epileptic syndrome."	( Chen, JY; Chen, YJ; Lee, IC; Su, PH; Yu, JS, 2009)

Excerpt	Reference
"To evaluate treatment responses in benign familial neonatal epilepsy (BFNE)."	( Bakken, EH; Balestri, M; Bellini, G; Cilio, MR; Danhaive, O; Holmes, GL; Mulkey, SB; Oldham, MS; Sands, TT; Taglialatela, M; Vigevano, F, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	2 (3.45)	12.5806
2000's	35 (60.34)	18.1394
2010's	17 (29.31)	28.8240
2020's	4 (6.90)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	3	0
carbamates	low	6	0
chlorine	low	1	0
pyridoxal phosphate	low	2	0
pyridoxine 5-phosphate	low	1	0
phenytoin	low	2	0
bumetanide	low	2	0
carbamazepine	medium	4	1
celecoxib	low	1	0
diazoxide	low	1	0
linopirdine	low	3	0
mepivacaine	low	1	0
midazolam	medium	2	1
phenobarbital	medium	12	4
vigabatrin	low	1	0
zonisamide	low	2	0
pentylenetetrazole	low	2	0
alanine	low	1	0
glutamine	low	2	0
valine	low	1	0
tryptophan	low	2	0
arginine	low	5	0
quinoxalines	low	2	0
isoxazoles	low	2	0
pyrimidine	low	1	0
flurothyl	low	1	0
bicuculline	low	2	0
alpha-aminopyridine	low	1	0
glutamic acid	low	3	0
oxcarbazepine	low	1	0
paroxetine	low	1	0
flupirtine	low	1	0
ezogabine	low	6	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
bms204352	low	1	0
xe 991, anthracenone	low	1	0
fg 9041	low	2	0
levetiracetam	medium	1	1
cysteine	low	1	0
technetium tc 99m exametazime	low	1	0
pituitrin	low	1	0
clove	low	1	0
vitamin b 12	low	1	0
flavin mononucleotide	low	1	0

Protein Targets (569)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Carbonic anhydrase 1	0	6	0	12
Carbonic anhydrase 2	0	6	1	13
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	1	8
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	2	0	3
AR protein	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Glutamate receptor 2	3	3	1	10
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Kappa-type opioid receptor	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	13	0	0	13
phosphopantetheinyl transferase	4	0	0	4
NFKB1 protein, partial	2	0	0	2
GLS protein	10	0	0	10
thyroid stimulating hormone receptor	9	0	0	9
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	9	0	0	9
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Cytochrome P450 3A4	0	1	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
geminin	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	10
Potassium voltage-gated channel subfamily KQT member 3	0	0	3	6
Potassium voltage-gated channel subfamily KQT member 2	0	1	3	7
Bile salt export pump	0	13	0	13
UDP-glucuronosyltransferase 2B7	0	1	1	4
Potassium voltage-gated channel subfamily KQT member 4	0	0	2	3
Calcium-activated potassium channel subunit alpha-1	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	9	0	9
Potassium voltage-gated channel subfamily KQT member 5	0	0	2	4
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
Luciferase	1	0	0	1
ATAD5 protein, partial	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
glucocorticoid receptor [Homo sapiens]	5	0	0	5
IDH1	3	0	0	3
Bloom syndrome protein isoform 1	9	0	0	9
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	0	7
Carbonic anhydrase 3	0	4	0	5
Carbonic anhydrase 4	0	5	0	8
Carbonic anhydrase 6	0	4	0	7
Carbonic anhydrase 5A, mitochondrial	0	4	1	8
Carbonic anhydrase 7	0	4	0	7
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase 9	0	5	0	8
Carbonic anhydrase 13	0	1	0	4
Carbonic anhydrase 14	0	4	0	7
Carbonic anhydrase 5B, mitochondrial	0	4	0	7
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	1	0	0	1
RAR-related orphan receptor gamma	3	0	0	3
USP1 protein, partial	5	0	0	5
TDP1 protein	9	0	0	9
estrogen-related nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid hormone receptor beta isoform a	5	0	0	5
mitogen-activated protein kinase 1	2	0	0	2
Vpr	1	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Cellular tumor antigen p53	4	0	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	1	3
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	2	0	4
Cytochrome P450 2J2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	1	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
SMAD family member 2	1	0	0	1
PPM1D protein	1	0	0	1
SMAD family member 3	1	0	0	1
GLI family zinc finger 3	5	0	0	5
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
progesterone receptor	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
EWS/FLI fusion protein	5	0	0	5
retinoid X nuclear receptor alpha	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
G	5	0	0	5
cytochrome P450 2D6	4	0	0	4
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
67.9K protein	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Carbonic anhydrase	0	2	0	2
Rac1 protein	0	0	1	1
caspase-3	1	0	0	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
activating transcription factor 6	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
caspase-3	1	0	0	1
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	4	0	11
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	2	0	2
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	2	0	2
Adenosine receptor A3	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	7	4	0	11
Alpha-1B adrenergic receptor	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	7	4	0	11
Gamma-aminobutyric acid receptor subunit gamma-2	7	4	1	12
5-hydroxytryptamine receptor 1A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	7	4	0	11
Gamma-aminobutyric acid receptor subunit alpha-3	7	4	0	11
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	7	4	0	11
Gamma-aminobutyric acid receptor subunit alpha-2	7	4	0	11
Sodium-dependent noradrenaline transporter	0	4	1	5
Adenosine receptor A1	0	1	0	1
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	4	0	11
Gamma-aminobutyric acid receptor subunit gamma-3	7	4	0	11
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	4	0	11
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	2	2	4
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	2	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	2	0	3
Alpha-1A adrenergic receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Carbonic anhydrase	0	2	0	3
Histone deacetylase 4	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	7	5	1	13
Gamma-aminobutyric acid receptor subunit beta-3	7	4	0	11
Gamma-aminobutyric acid receptor subunit beta-2	7	4	1	12
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Sodium-dependent dopamine transporter	0	4	1	5
Prostaglandin G/H synthase 2	0	1	0	1
Histone deacetylase 1	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	3	0	3
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	7	4	0	11
Inositol hexakisphosphate kinase 1	5	0	0	5
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	3	0	0	3
Carbonic anhydrase 15	0	3	0	4
Histone deacetylase 8	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	4	0	11
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
cytochrome P450 2C9, partial	5	0	0	5
regulator of G-protein signaling 4	6	0	0	6
cytochrome P450 2D6 isoform 1	3	0	0	3
D(1A) dopamine receptor	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	0	3	1	7
Glutamate receptor 3	0	3	1	7
Glutamate receptor 4	0	3	1	7
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
UDP-glucuronosyltransferase 1A9	0	0	1	1
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	1	1	2
UDP-glucuronosyltransferase 1A1	0	1	1	3
UDP-glucuronosyltransferase 1A4	0	1	1	3
UDP-glucuronosyltransferase 1A3	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	1	2
UDP-glucuronosyltransferase 2B15	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	2	0	2
Chain A, Glutamate Receptor Subunit 2	0	2	0	2
Chain B, Glutamate Receptor Subunit 2	0	2	0	2
Microtubule-associated protein tau	5	0	0	5
glucocerebrosidase	1	0	0	1
arylsulfatase A	7	0	0	7
fatty acid synthase	0	1	0	1
M-phase phosphoprotein 8	3	0	0	3
Glycoprotein hormones alpha chain	1	0	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	4
Glutamate receptor ionotropic, kainate 2	0	2	1	4
Glutamate receptor 1	0	4	1	5
Glutamate receptor 2	0	4	1	5
Glutamate receptor 3	0	3	1	4
Glutamate receptor ionotropic, kainate 3	0	2	0	3
Glutamate receptor 4	0	4	1	5
Guanine nucleotide-binding protein G	1	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	7
Glutamate receptor ionotropic, NMDA 2B	0	4	1	7
Glutamate receptor ionotropic, NMDA 2C	0	4	1	7
Glutamate receptor ionotropic, kainate 4	0	2	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	1	7
Glutamate receptor ionotropic, kainate 5	0	2	0	3
Glutamate receptor ionotropic, NMDA 3B	0	4	1	7
Glutamate receptor ionotropic, NMDA 3A	0	4	1	7
15-lipoxygenase, partial	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
vitamin D3 receptor isoform VDRA	2	0	0	2
glucokinase regulatory protein	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Histamine H2 receptor	4	0	0	4
Caspase-7	1	0	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
TAR DNA-binding protein 43	1	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	3	0	0	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Thrombopoietin	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Translocator protein	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
GALC protein	1	0	0	1
nonstructural protein 1	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Spike glycoprotein	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Myeloperoxidase	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	0	1	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
P2X purinoceptor 4	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Beta-adrenergic receptor kinase 1	0	0	0	1
Transporter	0	2	0	2
Alpha-synuclein	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
endonuclease IV	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Arginase 1	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Benign Familial Infantile Convulsions

Synonyms(30)

Research Excerpts

Overview

Treatment

Research

Studies (58)

Protein Targets (569)

Benign Familial Infantile Convulsions

Synonyms(30)

Research Excerpts

Overview

Treatment

Research

Studies (58)

Drugs Studied (50)

Protein Targets (569)