A rare heart defect that occurs when the HEART VENTRICLES and attached valves, the MITRAL VALVE and the TRICUSPID VALVE are reversed so that the AORTA and the PULMONARY ARTERY are connected to the wrong ventricle. Although the heart valves and the two great arteries, the PULMONARY ARTERY and the AORTA are transposed, the blood flows to the correct place because the ventricles are also reversed and therefore corrects the transposition. It often occurs with other structural heart abnormalities.
| Synonym |
|---|
| Congenitally Corrected Transposition of the Great Arteries |
| Congenitally Corrected Transposition of the Great Vessels |
| Congenitally Corrected Transposition |
| Excerpt | Reference |
|---|---|
| "Patients with congenitally corrected transposition were more likely to receive pharmacological treatment than patients after atrial switch operation." | ( Bauer, U; Bülow, T; Diller, GP; Gerhardus, M; Helm, P; Kerst, G; Lammers, AE; Lebherz, C; Marx, N; Tutarel, O, 2022) |
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|---|---|
| pre-1990 | 0 (0.00) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 0 (0.00) | 18.1394 |
| 2010's | 4 (57.14) | 28.8240 |
| 2020's | 3 (42.86) | 9.53 |
| Drug | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| valsartan | 0 | low | 2 | 0 |
| sacubitril | 0 | low | 3 | 0 |
| cardiovascular agents | 0 | low | 1 | 0 |
| natriuretic peptide, brain | 0 | medium | 4 | 1 |
| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|---|---|---|---|
| Atrial natriuretic peptide receptor 1 | 0 | 1 | 0 | 1 |
| Luciferase | 1 | 0 | 0 | 1 |
| ATP-binding cassette sub-family C member 3 | 0 | 1 | 0 | 1 |
| Multidrug resistance-associated protein 4 | 0 | 1 | 0 | 1 |
| Bile salt export pump | 0 | 1 | 0 | 1 |
| Thromboxane A2 receptor | 0 | 0 | 0 | 1 |
| Type-1A angiotensin II receptor | 0 | 1 | 1 | 2 |
| Type-1B angiotensin II receptor | 0 | 1 | 0 | 1 |
| Type-1 angiotensin II receptor | 0 | 2 | 1 | 4 |
| Type-1 angiotensin II receptor | 0 | 1 | 0 | 1 |
| Type-2 angiotensin II receptor | 0 | 1 | 0 | 1 |
| Spike glycoprotein | 1 | 0 | 0 | 1 |
| Squalene synthase | 0 | 1 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 1 | 0 | 1 |
| Platelet glycoprotein VI | 0 | 0 | 1 | 1 |
| Leukotriene B4 receptor 2 | 0 | 0 | 1 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | ||||