Analgesia, Congenital

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)

Synonym
Congenital Analgesia
Analgesia, Congenital
Congenital Insensitivity To Pain
Congenital Pain Insensitivity
Congenital Pain Indifference
Channelopathy-Associated Insensitivity To Pain
Pain Indifference, Congenital
Pain Insensitivity, Congenital
Insensitivity, Congenital Pain
Insensitivity To Pain, Congenital
Congenital Indifference to Pain

Excerpt	Reference
"Congenital analgesia is a rare genetic disorder."	( Li, M; Lu, CZ; Ma, L; Pei, G; Peng, YQ; Ren, XH; Wang, YP; Wu, DC; Wu, YL; Wu, YQ; Yin, DL; Zhou, TH, 1997)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	48 (61.54)	23.3326
1990's	5 (6.41)	12.5806
2000's	15 (19.23)	18.1394
2010's	5 (6.41)	28.8240
2020's	5 (6.41)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
chlorine	low	1	0
formaldehyde	low	1	0
histamine	low	4	0
iodine	low	2	0
nitrous oxide	low	2	0
uric acid	low	1	0
phenytoin	low	1	0
aspirin	low	1	0
enflurane	low	1	0
fentanyl	medium	4	2
hydralazine	low	1	0
imipramine	low	1	0
isoflurane	low	1	0
ketamine	low	1	0
midazolam	low	3	0
propofol	low	3	0
sevoflurane	low	1	0
levodopa	low	1	0
tyrosine	low	3	0
leucine	low	1	0
tryptophan	low	2	0
framycetin	low	1	0
ozone	low	2	0
trolamine salicylate	low	4	0
vecuronium bromide	low	1	0
fomesafen	medium	11	2
proline	low	1	0
3-(2-carboxyindol-3-yl)propionic acid	low	2	0
atropine	low	1	0
inositol 3-phosphate	low	3	0
enkephalin, leucine	low	4	0
capsaicin	low	3	0
thiopental	low	2	0
anandamide	low	1	0
naloxone	medium	16	4
morphine	low	4	0
beta-endorphin	low	2	0
exudates	low	1	0
prolyl-glycyl-proline	low	1	0
ego	low	1	0
preproenkephalin	low	1	0

Protein Targets (595)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
Glutamate receptor ionotropic, NMDA 1	0	5	0	9
Glutamate receptor ionotropic, NMDA 2A	0	4	0	8
Glutamate receptor ionotropic, NMDA 2B	0	4	0	8
Glutamate receptor ionotropic, NMDA 2C	0	4	0	8
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	4	0	8
Glutamate receptor ionotropic, NMDA 3B	0	4	0	8
Glutamate receptor ionotropic, NMDA 3A	0	4	0	8
estrogen nuclear receptor alpha	13	0	0	13
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
phosphopantetheinyl transferase	6	0	0	6
Bloom syndrome protein isoform 1	6	0	0	6
vitamin D3 receptor isoform VDRA	1	0	0	1
DNA polymerase kappa isoform 1	4	0	0	4
Fatty-acid amide hydrolase 1	0	3	0	3
Fatty-acid amide hydrolase 1	0	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	0	1	1
Glutamate receptor 2	2	0	1	3
Glutamate receptor 3	0	0	1	1
Glutamate receptor 4	0	0	1	1
Cannabinoid receptor 1	0	1	1	2
Cannabinoid receptor 1	0	2	0	3
Cannabinoid receptor 2	0	2	0	3
Alpha-1A adrenergic receptor	0	3	0	3
Cannabinoid receptor 1	0	1	0	1
Histamine H2 receptor	3	1	1	6
Cannabinoid receptor 2	0	1	0	1
Fatty-acid amide hydrolase 1	0	4	0	5
Fatty acid-binding protein 5	0	0	1	1
Corticotropin-releasing factor receptor 2	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	2	6
Cannabinoid receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	6	0	0	6
GLS protein	8	0	0	8
AR protein	9	0	0	9
thyroid stimulating hormone receptor	4	0	0	4
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	3	0	0	3
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
estrogen-related nuclear receptor alpha	8	0	0	8
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	1	0	0	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	13	0	13
Epidermal growth factor receptor	0	2	0	2
Carbonic anhydrase 1	0	4	0	8
Carbonic anhydrase 2	0	4	0	9
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	1	0	4
Adenosine receptor A2a	0	1	0	4
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	5	1	9
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	3	1	4
GLI family zinc finger 3	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
retinoid X nuclear receptor alpha	4	0	0	4
pregnane X nuclear receptor	10	0	0	10
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	5	0	6
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	4	1	7
Muscarinic acetylcholine receptor M3	0	4	1	7
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M1	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	5	0	5
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
regulator of G-protein signaling 4	4	0	0	4
histone acetyltransferase KAT2A isoform 1	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
RAR-related orphan receptor gamma	7	0	0	7
TDP1 protein	4	0	0	4
Microtubule-associated protein tau	4	0	0	4
estrogen receptor 2 (ER beta)	2	0	0	2
progesterone receptor	5	0	0	5
67.9K protein	1	0	0	1
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	6	0	0	6
mitogen-activated protein kinase 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
nuclear receptor ROR-gamma isoform 1	3	0	0	3
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
lamin isoform A-delta10	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	3	4	1	8
Transient receptor potential cation channel subfamily V member 1	0	2	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Cytochrome P450 1A2	0	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	4	1	8
Gamma-aminobutyric acid receptor subunit delta	3	4	1	8
Gamma-aminobutyric acid receptor subunit gamma-2	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-3	3	4	1	8
Acetylcholinesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-2	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	3	4	1	8
Gamma-aminobutyric acid receptor subunit gamma-3	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-6	3	4	1	8
Spike glycoprotein	4	0	0	4
D(2) dopamine receptor	0	1	2	3
Gamma-aminobutyric acid receptor subunit beta-3	3	4	1	8
Gamma-aminobutyric acid receptor subunit beta-2	3	4	1	8
Inositol monophosphatase 1	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
GABA theta subunit	3	4	1	8
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	3	4	1	8
ATP-dependent phosphofructokinase	4	0	0	4
Carbonic anhydrase 4	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 15	0	1	0	5
Opioid receptor, delta 1b	0	2	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	7	2	12
Delta-type opioid receptor	0	7	3	11
Kappa-type opioid receptor	0	4	1	7
Mu-type opioid receptor	0	7	4	14
Kappa-type opioid receptor	0	5	3	9
Mu-type opioid receptor	0	8	4	14
Delta-type opioid receptor	0	7	3	12
Kappa-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	7	4	13
Mu-type opioid receptor	0	5	1	9
Mu-type opioid receptor	0	8	1	9
Mu-type opioid receptor	0	2	0	2
Luciferase	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	3	0	3
D(2) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Histamine H1 receptor	0	5	2	7
D(3) dopamine receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	3	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Histone H2A.x	3	0	0	3
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
USP1 protein, partial	4	0	0	4
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Carbonic anhydrase 12	0	0	0	4
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	4
Carbonic anhydrase 3	0	0	0	4
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	0	0	4
Histamine H2 receptor	0	1	2	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	3	1	4
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	4
Carbonic anhydrase 7	0	0	0	4
Carbonic anhydrase	0	0	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	4
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase-like protein, putative	0	0	0	4
Carbonic anhydrase	0	0	0	5
Carbonic anhydrase	0	0	0	5
Solute carrier family 22 member 1	0	2	0	3
Carbonic anhydrase	0	0	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Carbonic anhydrase 14	0	0	0	4
Carbonic anhydrase 5B, mitochondrial	0	0	0	4
Histamine H3 receptor	0	1	2	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
ATAD5 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
Parkin	1	0	0	1
arylsulfatase A	4	0	0	4
pyruvate kinase	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Ataxin-2	2	0	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Snq2p	0	0	0	1
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Major prion protein	0	0	1	1
Cellular tumor antigen p53	3	0	0	3
Cytochrome P450 3A4	0	2	1	4
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2C19	0	0	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transporter	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
acetylcholinesterase	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
geminin	4	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	4	0	4
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	2	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
snurportin-1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Polyphenol oxidase 2	0	0	0	2
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	1	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Alpha-2A adrenergic receptor	0	0	1	1
Histidine decarboxylase	0	0	2	2
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	2	2
Adenosine receptor A1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Gamma-aminobutyric acid	0	1	0	1
endonuclease IV	1	0	0	1
G	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
farnesoid X nuclear receptor	2	0	0	2
caspase-3	1	0	0	1
heat shock protein beta-1	2	0	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(11)

Research Excerpts

Overview

Research

Studies (78)

Protein Targets (595)

Analgesia, Congenital

Synonyms(11)

Research Excerpts

Overview

Research

Studies (78)

Drugs Studied (60)

Protein Targets (595)