Congenital Mesoblastic Nephroma

A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.

Synonym
Congenital Mesoblastic Nephroma
Mesoblastic Nephroma
Nephroma, Mesoblastic

Excerpt	Reference
"Mesoblastic nephroma is by far the most frequent intrarenal fetal tumor."	( Allal, H; Forgues, D; Galifer, RB; Garnier, S; Guibal, MP; Haouy, S; Kalfa, N; Maillet, O; Sabatier, E; Saguintaah, M; Serre, I, 2012)
"Congenital mesoblastic nephroma is a rare pediatric renal tumor and has been reported in patients presenting with palpable abdominal mass, arterial hypertension, hematuria, polyuria, or hypercalcemia."	( Bacchetta, J; Bordet, F; Dijoud, F; Duncan, A; Mure, PY; Pracros, JP; Tanné, C, 2022)

Excerpt	Reference
"Congenital mesoblastic nephroma was diagnosed, and the patient received postoperative chemotherapy."	( Boldrini, R; Caione, P; De Pasquale, MD; Diomedi-Camassei, F; Inserra, A; Jenkner, A; Serra, A, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	4 (20.00)	12.5806
2000's	5 (25.00)	18.1394
2010's	6 (30.00)	28.8240
2020's	5 (25.00)	9.53

Drug	Relationship Strength	Studies
normetanephrine	low	1
vanilmandelic acid	low	1
furosemide	low	1
ifosfamide	low	1
pamidronate	low	1
aldosterone	low	1
9,10-dimethyl-1,2-benzanthracene	low	1
dimethylnitrosamine	low	1
azacitidine	low	1
pseudouridine	low	1
tetradecanoylphorbol acetate	low	1
etoposide	low	1
fluorodeoxyglucose f18	low	1
diethylstilbestrol	low	1
decitabine	low	1
dactinomycin	low	1
bromochloroacetic acid	low	2
leuprolide	low	1
cyclin d1	low	3
technetium tc 99m dimercaptosuccinic acid	low	1

Protein Targets (315)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	5	0	0	5
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, Cruzipain	3	0	0	3
Luciferase	2	0	0	2
acid sphingomyelinase	1	0	0	1
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	8	0	0	8
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	4	0	0	4
SMAD family member 3	2	0	0	2
TDP1 protein	6	0	0	6
GLI family zinc finger 3	6	0	0	6
AR protein	9	0	0	9
apical membrane antigen 1, AMA1	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	6	0	0	6
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	8	0	0	8
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	6	0	0	6
estrogen nuclear receptor alpha	9	0	0	9
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Caspase-7	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
chromobox protein homolog 1	5	0	0	5
thyroid hormone receptor beta isoform a	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	9	0	0	9
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	9	0	0	9
cytochrome P450 3A4 isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Cellular tumor antigen p53	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Nuclear receptor ROR-gamma	5	0	0	5
Caspase-7	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
GABA theta subunit	3	0	0	3
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	2	0	2
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
interleukin 8	3	0	0	3
glp-1 receptor, partial	3	0	0	3
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
PPM1D protein	1	0	0	1
Thrombopoietin	1	0	0	1
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
polyprotein	1	0	0	1
67.9K protein	4	0	0	4
Parkin	1	0	0	1
arylsulfatase A	2	0	0	2
Bloom syndrome protein isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peripheral myelin protein 22	3	0	0	3
histone acetyltransferase KAT2A isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
lamin isoform A-delta10	4	0	0	4
Interferon beta	3	0	0	3
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Adenosine receptor A3	0	3	0	3
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Adenosine receptor A2a	0	3	0	3
Adenosine receptor A1	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
Spike glycoprotein	5	0	0	5
Multidrug and toxin extrusion protein 1	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
USP1 protein, partial	2	0	0	2
Microtubule-associated protein tau	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
RAD51	0	1	0	1
Histone H2A.x	3	0	0	3
vitamin D3 receptor isoform VDRA	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
ATP-dependent translocase ABCB1	0	2	0	4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
EWS/FLI fusion protein	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	5	0	6
acetylcholinesterase	1	0	0	1
GLS protein	3	0	0	3
regulator of G-protein signaling 4	1	0	0	1
G	1	0	0	1
cytochrome P450 2D6	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	1	0	1
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	3
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	2	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Glycine receptor subunit alpha-2	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Aldehyde oxidase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Estrogen receptor beta	0	2	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Cysteinyl leukotriene receptor 1	0	2	0	2
cytochrome P450 2C9, partial	1	0	0	1
thioredoxin reductase	2	0	0	2
ORF73	0	0	1	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Cytochrome P450 2C9	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Bile salt export pump	0	1	0	1
Albumin	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
GALC protein	1	0	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Congenital Mesoblastic Nephroma

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (20)

Protein Targets (315)

Congenital Mesoblastic Nephroma

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (20)

Drugs Studied (24)

Protein Targets (315)