Page last updated: 2024-09-28

Coma, Hyperglycemic Hyperosmolar Nonketotic

A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.

Synonyms(8)

Synonym
Coma, Hyperglycemic Hyperosmolar Nonketotic
Hyperosmolar Hyperglycemic Nonketotic Coma
Hyperosmolar Hyperglycemic State
Hyperosmolar Hyperglycemic Syndrome
Hyperosmolar Nonketotic Coma
Hyperglycemic Hyperosmolar Nonketotic Coma
Nonketotic Hyperglycemic Coma
Nonketotic Hyperosmolar Coma

Research Excerpts

Overview

ExcerptReference
"Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose, hyperosmolarity, and little or no ketosis."( Stoner, GD, 2005)
"Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose and hyperosmolarity with little or no ketosis."( Stoner, GD, 2017)

Treatment

ExcerptReference
"Two diabetic children with nonketotic hyperosmolar coma were treated successfully."( Mayama, H; Yamamoto, T; Yamashiro, Y, 1981)
"The patient presented with an atypical hyperosmolar hyperglycemic state and diabetic ketoacidosis but recovered after insulin pump treatment and fluid supplementation."( Chang, CW; Kao, YH; Ku, SJ; Lam, HC; Lu, YC; Tseng, KB; Wang, CT, 2020)

Research

Studies (209)

TimeframeStudies, This Condition (%)All Conditions %
pre-199086 (41.15)23.3326
1990's35 (16.75)12.5806
2000's38 (18.18)18.1394
2010's31 (14.83)28.8240
2020's19 (9.09)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
acetone0low20
chlorine0low20
3-hydroxybutyric acid0low40
creatine0low10
lactic acid0low40
glycine0low40
glycerol0low20
hydrogen carbonate0low130
methanol0low10
urea0low30
chlorocresol0low10
phenytoin0low20
amoxapine0low10
carbamazepine0low10
carbazilquinone0low10
chlorpropamide0low10
chlorthalidone0low10
dantrolene0low20
diazoxide0low30
distigmine0low10
fentanyl0low10
fluorouracil0low10
furosemide0low30
gabapentin0low10
glimepiride0low10
glyburide0low10
haloperidol0low20
hydrochlorothiazide0low30
loxapine0low10
metformin0low40
methadone0low10
metolazone0low10
perphenazine0low10
pirenzepine0low10
potassium chloride0low10
propranolol0low10
sulpiride0low10
tolbutamide0low20
trifluoperazine0low10
prednisolone0low20
thyroxine0low20
aldosterone0low10
prednisone0low30
triiodothyronine0low10
biguanides0low10
tetrabenazine0low10
carbostyril0low10
levodopa0low10
mannitol0low20
lithium carbonate0low10
fructosamine0low20
n-methylaspartate0low10
zidovudine0low10
tobramycin0low10
dobutamine0low10
diltiazem0low10
itraconazole0low10
aripiprazole0low10
capecitabine0low10
potassium phosphate0low10
fibrinogen0low10
aspartame0low10
lithium chloride0low10
glycogen0low10
strychnine0low10
sodium bicarbonate0low20
glycosides0low10
picibanil0low10
arginine vasopressin0low20
methimazole0low10
D-fructopyranose0low10
lithium0low60
naloxone0low10
deamino arginine vasopressin0low30
dextromethorphan0low10
dextrorphan0low10
lurasidone hydrochloride0low10
technetium tc 99m exametazime0low10
pituitrin0low30
atrial natriuretic factor0low10
glucagon0medium61
c-peptide0low30
ro13-99040low10
quetiapine fumarate0low10
exenatide0low10
humulin s0low20
insulin degludec0low10
cyclosporine0low10
levoleucovorin0low10
didanosine0low10
olanzapine0low40
leptin0low10

Protein Targets (828)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase5005
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0002
Carbonic anhydrase 0404
thioredoxin reductase180018
GALC protein4004
GLI family zinc finger 3270027
nuclear receptor subfamily 1, group I, member 3180018
cytochrome P450 family 3 subfamily A polypeptide 4180018
glucocorticoid receptor [Homo sapiens]260026
retinoic acid nuclear receptor alpha variant 1220022
retinoid X nuclear receptor alpha180018
estrogen-related nuclear receptor alpha250025
Carbonic anhydrase 0303
Carbonic anhydrase 0202
arylsulfatase A120012
Carbonic anhydrase0202
euchromatic histone-lysine N-methyltransferase 2280028
Bloom syndrome protein isoform 19009
thyroid hormone receptor beta isoform a130013
nuclear factor erythroid 2-related factor 2 isoform 1230023
geminin290029
peripheral myelin protein 22150015
survival motor neuron protein isoform d110011
muscleblind-like protein 1 isoform 14004
Gamma-aminobutyric acid receptor subunit pi115218
ATP-binding cassette sub-family C member 3028028
Multidrug resistance-associated protein 4028028
Carbonic anhydrase0202
Solute carrier family 22 member 60607
Carbonic anhydrase 1209117
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump037037
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 1014125
Carbonic anhydrase 2016126
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 309114
Cathepsin B0101
Cytochrome P450 3A40709
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0718
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80202
Cytochrome P450 2D60506
Cytochrome P450 2A60101
Cytochrome P450 2C9 016016
5-hydroxytryptamine receptor 2A0617
Androgen receptor0303
Gamma-aminobutyric acid receptor subunit beta-1115218
Translocator protein0112
Gamma-aminobutyric acid receptor subunit delta115218
Gamma-aminobutyric acid receptor subunit gamma-2115319
Gamma-aminobutyric acid receptor subunit alpha-5115218
Gamma-aminobutyric acid receptor subunit alpha-3115218
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60213
Carbonic anhydrase 4012119
Carbonic anhydrase 609116
Gamma-aminobutyric acid receptor subunit gamma-1115218
Gamma-aminobutyric acid receptor subunit alpha-2115218
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10304
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40102
Gamma-aminobutyric acid receptor subunit alpha-4115218
Gamma-aminobutyric acid receptor subunit gamma-3115218
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-6115218
Adenosine receptor A2a0102
5-hydroxytryptamine receptor 2B0516
Sodium-dependent serotonin transporter0303
Delta-type opioid receptor0719
Cytochrome P450 2C190202
Delta-type opioid receptor08210
Mu-type opioid receptor09312
Carbonic anhydrase 5A, mitochondrial011119
Carbonic anhydrase0406
Kappa-type opioid receptor0718
Carbonic anhydrase 709116
Carbonic anhydrase0101
D(1A) dopamine receptor3205
Corticosteroid 11-beta-dehydrogenase isozyme 10202
Carbonic anhydrase0204
D(2) dopamine receptor09110
Gamma-aminobutyric acid receptor subunit alpha-1115319
Gamma-aminobutyric acid receptor subunit beta-3115218
Gamma-aminobutyric acid receptor subunit beta-2115319
Cholinesterase0202
Carbonic anhydrase 0101
Mu-type opioid receptor0718
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Glutamate receptor ionotropic, NMDA 2B09214
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 9011120
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0303
Carbonic anhydrase 0204
Carbonic anhydrase 30101
Carbonic anhydrase0104
Carbonic anhydrase0205
Carbonic anhydrase 0303
Sigma intracellular receptor 20202
Delta carbonic anhydrase0303
Sigma non-opioid intracellular receptor 10819
Renin0101
Carbonic anhydrase 0204
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130416
GABA theta subunit115218
Canalicular multispecific organic anion transporter 1026026
Carbonic anhydrase 40303
Carbonic anhydrase 150508
Acidic mammalian chitinase0101
Carbonic anhydrase 1306012
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon115218
Carbonic anhydrase 0202
Carbonic anhydrase 1408116
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial010118
TDP1 protein270027
thyroid hormone receptor beta isoform 2190019
lamin isoform A-delta10280028
AR protein300030
nuclear factor erythroid 2-related factor 2 isoform 28008
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0303
Mineralocorticoid receptor 0336
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G6006
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, Ferritin light chain7007
endonuclease IV6006
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma200020
Fumarate hydratase6006
USP1 protein, partial120012
NFKB1 protein, partial6006
GLS protein160016
Thrombopoietin5005
aldehyde dehydrogenase 1 family, member A1190019
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
thyroid stimulating hormone receptor190019
progesterone receptor130013
isocitrate dehydrogenase 1, partial1001
EWS/FLI fusion protein160016
estrogen nuclear receptor alpha360036
cytochrome P450 2D6110011
polyprotein6006
67.9K protein7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
activating transcription factor 67007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)140014
cytochrome P450 2D6 isoform 18008
peripheral myelin protein 22 isoform 1100010
cellular tumor antigen p53 isoform a4004
D(1A) dopamine receptor130013
atrial natriuretic peptide receptor 1 precursor5005
vitamin D3 receptor isoform VDRA7007
chromobox protein homolog 1180018
potassium voltage-gated channel subfamily H member 2 isoform d130013
heat shock protein beta-15005
atrial natriuretic peptide receptor 2 precursor4004
ubiquitin carboxyl-terminal hydrolase 2 isoform a6006
serine/threonine-protein kinase mTOR isoform 17007
cytochrome P450 3A4 isoform 1110011
M-phase phosphoprotein 86006
transient receptor potential cation channel subfamily V member 13003
histone acetyltransferase KAT2A isoform 1110011
muscarinic acetylcholine receptor M1140014
neuropeptide S receptor isoform A6006
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
5-hydroxytryptamine receptor 40808
Cellular tumor antigen p53170017
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20718
Muscarinic acetylcholine receptor M40707
5-hydroxytryptamine receptor 1A0628
Muscarinic acetylcholine receptor M50808
Alpha-2A adrenergic receptor09212
Muscarinic acetylcholine receptor M109313
D(2) dopamine receptor016423
Alpha-2B adrenergic receptor08110
Alpha-2C adrenergic receptor08211
Muscarinic acetylcholine receptor M309110
D(1A) dopamine receptor08110
D(4) dopamine receptor011114
Sodium-dependent noradrenaline transporter 0707
Alpha-1D adrenergic receptor09111
5-hydroxytryptamine receptor 2A011112
5-hydroxytryptamine receptor 2C010111
Sodium-dependent serotonin transporter013013
5-hydroxytryptamine receptor 70718
Histamine H1 receptor09110
D(3) dopamine receptor014321
5-hydroxytryptamine receptor 2B09110
Histamine H2 receptor90010
Sulfotransferase 1A10101
5-hydroxytryptamine receptor 609110
Disintegrin and metalloproteinase domain-containing protein 174004
Inositol monophosphatase 17007
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sulfotransferase 2A10101
TAR DNA-binding protein 436006
Ataxin-29009
Histamine H4 receptor0213
ATP-dependent phosphofructokinase130013
glucocerebrosidase7007
DNA polymerase kappa isoform 15005
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0336
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Vasopressin V2 receptor0326
Oxytocin receptor0123
Vasopressin V1a receptor0022
Vasopressin V1a receptor0336
Vasopressin V1b receptor0224
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0203
Oxytocin receptor0101
Vasopressin V2 receptor 0224
Chain A, JmjC domain-containing histone demethylation protein 3A8008
5-hydroxytryptamine receptor 3E0202
acetylcholinesterase9009
SMAD family member 25005
PPM1D protein1001
SMAD family member 35005
Microtubule-associated protein tau9009
estrogen receptor 2 (ER beta)120012
farnesoid X nuclear receptor100010
pregnane X nuclear receptor240024
G100010
peroxisome proliferator-activated receptor delta100010
peroxisome proliferator activated receptor gamma110011
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)5005
thyroid stimulating hormone receptor5005
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10022
transcriptional regulator ERG isoform 35005
nuclear receptor ROR-gamma isoform 1110011
5-hydroxytryptamine receptor 2A0022
Solute carrier family 22 member 20202
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit6006
5-hydroxytryptamine receptor 3B0202
Interferon beta110011
HLA class I histocompatibility antigen, B alpha chain 100010
ATP-dependent translocase ABCB1010012
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Alpha-1B adrenergic receptor0718
D0505
5-hydroxytryptamine receptor 1A09111
Glutamate receptor 26109
D(1B) dopamine receptor0304
Alpha-1D adrenergic receptor0718
D(4) dopamine receptor0505
Histamine H1 receptor0213
5-hydroxytryptamine receptor 7 0303
Alpha-1A adrenergic receptor0528
Alpha-1B adrenergic receptor0315
Alpha-1A adrenergic receptor0718
5-hydroxytryptamine receptor 3A0202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Spike glycoprotein110011
Potassium voltage-gated channel subfamily H member 2017017
5-hydroxytryptamine receptor 3D0202
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0202
Inositol hexakisphosphate kinase 1100010
Multidrug and toxin extrusion protein 10404
Histamine H3 receptor0101
cytochrome P450 2C9, partial100010
aryl hydrocarbon receptor140014
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Liver carboxylesterase 10001
IDH14004
mitogen-activated protein kinase 15005
Vpr3003
Bile salt export pump0909
Albumin0044
Major prion protein0022
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0202
UDP-glucuronosyltransferase 2B70205
Sodium channel protein type 4 subunit alpha0507
Cytochrome P450 2J2011011
Sodium channel protein type 9 subunit alpha0505
Frizzled-80011
P2X purinoceptor 40101
Smad34004
nuclear receptor subfamily 1, group I, member 23003
importin subunit beta-1 isoform 14004
snurportin-14004
DNA polymerase iota isoform a (long)7007
Glycoprotein hormones alpha chain2002
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, serum paraoxonase0101
Neutrophil cytosol factor 10101
Poly [ADP-ribose] polymerase tankyrase-20101
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Nuclear receptor ROR-gamma2002
cytochrome P450 2C19 precursor5005
flap endonuclease 1100010
Albumin0448
Lanosterol 14-alpha demethylase0303
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
dopamine D1 receptor5005
pregnane X receptor3003
regulator of G-protein signaling 4130013
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10707
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Potassium voltage-gated channel subfamily A member 10112
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10303
Solute carrier family 22 member 1 0808
Glutamate receptor ionotropic, NMDA 2D0303
Glutamate receptor ionotropic, NMDA 3B0303
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Muscarinic acetylcholine receptor M20606
Neuronal acetylcholine receptor subunit beta-40101
Cytochrome P450 2D30101
Glutamate receptor ionotropic, NMDA 1 08213
Taste receptor type 2 member 460022
Glutamate receptor ionotropic, NMDA 2A 08213
Glutamate receptor ionotropic, NMDA 2C08213
Glutamate receptor ionotropic, NMDA 10505
Glutamate receptor ionotropic, NMDA 2A0505
Glutamate receptor ionotropic, NMDA 2B0505
Glutamate receptor ionotropic, NMDA 2C0303
Glutamate receptor ionotropic, NMDA 2D08213
Cytochrome P450 2D40101
Glutamate receptor ionotropic, NMDA 3A0303
Glutamate receptor ionotropic, NMDA 3B08213
Sigma non-opioid intracellular receptor 1011011
Sigma non-opioid intracellular receptor 10505
Glutamate receptor ionotropic, NMDA 3A08213
Acetylcholinesterase0202
ATAD5 protein, partial100010
GTP-binding nuclear protein Ran isoform 11001
Coagulation factor VII0101
Tissue factor0101
Glutamate receptor 10103
Glutamate receptor 30103
Glutamate receptor 40103
Nicotinamide phosphoribosyltransferase0011
ATP-binding cassette sub-family C member 80213
ATP-sensitive inward rectifier potassium channel 110213
Reverse transcriptase/RNaseH 0227
huntingtin isoform 23003
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Voltage-dependent L-type calcium channel subunit alpha-1F0404
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Voltage-dependent L-type calcium channel subunit alpha-1D0202
Sodium channel protein type 1 subunit alpha0303
5-hydroxytryptamine receptor 70303
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0505
Sodium channel protein type 5 subunit alpha0404
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0202
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Sodium channel protein type 8 subunit alpha0202
Sodium channel protein type 10 subunit alpha0202
glp-1 receptor, partial7007
phosphopantetheinyl transferase8008
Histone H2A.x4004
Epidermal growth factor receptor0303
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0202
Beta-2 adrenergic receptor0415
Beta-1 adrenergic receptor0415
Polyunsaturated fatty acid lipoxygenase ALOX150303
POU domain, class 2, transcription factor 10001
Sodium-dependent dopamine transporter 0303
Luciferase5005
Nuclear receptor subfamily 1 group I member 20022
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Kappa-type opioid receptor0325
Mu-type opioid receptor09414
Delta-type opioid receptor0629
Kappa-type opioid receptor06310
Mu-type opioid receptor0203
Chain A, Uracil Phosphoribosyltransferase0101
interleukin 81001
Skn7p0001
nonstructural protein 13003
hemoglobin subunit beta1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Solute carrier family 22 member 80001
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
ATPase family AAA domain-containing protein 53003
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
thyrotropin-releasing hormone receptor1001
Glucose-6-phosphate 1-dehydrogenase0202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0202
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10404
thioredoxin glutathione reductase3003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30012
Hsf1 protein0022
bromodomain adjacent to zinc finger domain 2B3003
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10023
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit rho-20012
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50314
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit beta-10112
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit epsilon0303
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60314
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit pi0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30303
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40112
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0303
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
cytochrome P450 2C9 precursor5005
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
Parkin1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
ATP-binding cassette sub-family C member 90101
Solute carrier organic anion transporter family member 2B1 0001
Potassium channel subfamily K member 20235
Chymotrypsinogen A0101
Beta-lactamase0101
ATP synthase subunit beta, mitochondrial0101
ATP synthase subunit delta, mitochondrial0101
ATP synthase subunit gamma, mitochondrial0101
ATP synthase subunit epsilon, mitochondrial0101
Cystic fibrosis transmembrane conductance regulator0101
Cholesteryl ester transfer protein0101
Peroxisome proliferator-activated receptor gamma0145
Malate dehydrogenase, cytoplasmic0101
Solute carrier family 15 member 10101
Solute carrier family 22 member 70102
Solute carrier family 15 member 20101
NACHT, LRR and PYD domains-containing protein 3 0101
NACHT, LRR and PYD domains-containing protein 3 0101
Solute carrier organic anion transporter family member 1B10103
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Glycine receptor subunit alpha-10213
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10303
Serine racemase0101
Olfactory receptor 51E20022
Sodium- and chloride-dependent glycine transporter 20101
15-lipoxygenase, partial3003
caspase 7, apoptosis-related cysteine protease4004
caspase-34004
Adenylate cyclase type 1 0101
lethal factor (plasmid)5005
Cocaine esterase0101
Transient receptor potential cation channel subfamily V member 10101
UDP-glucuronosyltransferase 1A90102
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Muscarinic acetylcholine receptor M10505
Muscarinic acetylcholine receptor M30505
Muscarinic acetylcholine receptor M40505
Muscarinic acetylcholine receptor M50505
Beta-2 adrenergic receptor0405
Angiotensin-converting enzyme0606
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
Beta-1 adrenergic receptor0315
D(3) dopamine receptor0606
Alpha-2B adrenergic receptor0213
D(2) dopamine receptor0202
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0213
UDP-glucuronosyltransferase 1A40104
Alpha-2A adrenergic receptor0213
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0202
D(1B) dopamine receptor0303
Beta-3 adrenergic receptor0303
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
Histamine H1 receptor0303
C-8 sterol isomerase0202
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Transporter0202
Cholecystokinin receptor type A0101
Protease 0314
Adenylyl cyclase 7 0101
D0101
Transient receptor potential cation channel subfamily V member 40101
Transient receptor potential cation channel subfamily V member 20101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Rap guanine nucleotide exchange factor 33003
Integrin beta-33003
Integrin alpha-IIb3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA15005
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 12002
Polyphenol oxidase 20204
Plasma kallikrein0002
Tyrosinase0101
Solute carrier family 15 member 10101
SLC16A10 protein0002
Carbonic anhydrase-like protein, putative0002
Monocarboxylate transporter 100002
phosphoglycerate kinase1001
inositol monophosphatase 11001
Cholecystokinin receptor type A1001
Gastrin/cholecystokinin type B receptor1001
Glycogen synthase kinase-3 beta0112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Dihydrofolate reductase0303
Solute carrier family 22 member 10001
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0202
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
acid sphingomyelinase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Glutamate receptor ionotropic, kainate 10101
Glutamate receptor ionotropic, kainate 20101
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, kainate 40101
Glutamate receptor ionotropic, kainate 50101
Histidine decarboxylase0011
Adenosine receptor A10303
Kappa-type opioid receptor0102
Beta-2 adrenergic receptor0214
UDP-glucuronosyltransferase 1A80001
FAD-linked sulfhydryl oxidase ALR0001
Nuclear receptor subfamily 3 group C member 3 0505
Transporter0101
NADPH oxidase 10202
Snq2p0002
Caspase-72002
NPC intracellular cholesterol transporter 1 precursor2002
caspase-32002
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A2002
protein AF-9 isoform a0001
bcl-2-related protein A10101
DNA repair protein RAD52 homolog isoform a0002
Aldehyde oxidase 10101
Retinal dehydrogenase 10101
Pleiotropic ABC efflux transporter of multiple drugs0204
Aldehyde oxidase0101
Aldehyde oxidase 10101
Rap guanine nucleotide exchange factor 41001
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor DM10101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Androgen receptor0303
Glutamine synthetase0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Beta-1 adrenergic receptor 0113
Adenosine receptor A30112
Beta-3 adrenergic receptor0213
Endothelin-1 receptor0112
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Beta-2 adrenergic receptor0101
Nuclear receptor subfamily 2 group E member 10022
Glycine receptor subunit beta0101
Taste receptor type 2 member 100012
D(2) dopamine receptor0101
DNA polymerase beta1001
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK12002
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0202
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30003
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Protein Rev 0011
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 2B10 0101
Genome polyprotein 0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Ubiquitin carboxyl-terminal hydrolase 10101
Lysozyme C-10101
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Calmodulin-10011
Trypanothione reductase0202
Calmodulin 0011
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
WD repeat-containing protein 480101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
Prothrombin0011
Thyroid hormone receptor beta0101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Phospholipase A-2-activating protein0101
Urease subunit alpha0101
Urease subunit beta0101
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 60001
Solute carrier family 22 member 80001
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]