Page last updated: 2024-09-27

Collagenous Sprue

A malabsorption syndrome characterized by collagenous mucosal lesions of the SMALL INTESTINE, atrophy of MICROVILLI, severe malabsorption, diarrhea, and MALNUTRITION often refractory to a gluten-free diet.

Synonyms(1)

Synonym
Collagenous Sprue

Research Excerpts

Overview

ExcerptReference
"Collagenous sprue is a rare clinicopathological condition of the small bowel."( Nielsen, OH; Riis, LB; Soendergaard, C, 2014)

Research

Studies (8)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's7 (87.50)28.8240
2020's1 (12.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
prednisolone0low10
olmesartan medoxomil0low10
olmesartan0low50
pulmicort0low10

Protein Targets (109)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase2002
euchromatic histone-lysine N-methyltransferase 22002
Cytochrome P450 2C9 0202
Cytochrome P450 2J20202
Spike glycoprotein1001
Platelet glycoprotein VI0011
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Cruzipain1001
TDP1 protein3003
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Bile salt export pump0303
Albumin0001
Cellular tumor antigen p533003
Gamma-aminobutyric acid receptor subunit beta-12002
UDP-glucuronosyltransferase 2B70001
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
luciferase0001
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma2002
GLI family zinc finger 32002
AR protein2002
progesterone receptor2002
cytochrome P450 family 3 subfamily A polypeptide 42002
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 12002
estrogen-related nuclear receptor alpha2002
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha2002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
nuclear receptor subfamily 1, group I, member 22002
nuclear factor erythroid 2-related factor 2 isoform 21001
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta2002
Fatty acid-binding protein, liver0101
Estrogen receptor0303
Glucocorticoid receptor04211
Progesterone receptor0304
Glucocorticoid receptor0213
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0325
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0303
Glutamate receptor 22002
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0303
Canalicular multispecific organic anion transporter 10202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
glp-1 receptor, partial1001
SMAD family member 21001
NFKB1 protein, partial1001
GLS protein1001
SMAD family member 31001
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen receptor 2 (ER beta)1001
retinoid X nuclear receptor alpha1001
G1001
cytochrome P450 2D61001
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
thyroid hormone receptor beta isoform 21001
nuclear factor erythroid 2-related factor 2 isoform 11001
nuclear receptor ROR-gamma isoform 11001
geminin1001
survival motor neuron protein isoform d1001
HLA class I histocompatibility antigen, B alpha chain 1001
Interleukin-50101
Interleukin-50101
Matrix metalloproteinase-90101
Interleukin-5 receptor subunit alpha0101
Sodium-dependent serotonin transporter0101
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]