Collagenous Fibroma

An extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)

Synonym
Desmoplastic Fibroblastoma
Collagenous Fibroma
Fibroma, Desmoplastic

Excerpt	Reference
"Skeletal desmoplastic fibroma is an intraosseous neoplasm that is recognized as a very scare benign tumor."	( Chen, YG; Lu, QN; Peng, LL; Qiao, JG; Sun, YH; Zhao, Y, 2008)

Excerpt	Reference
"We present a case of desmoplastic fibroma (DF) arising from the right scapula that was incidentally identified by fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging performed to evaluate the presence of metastasis due to a history of surgical treatment for endometrioid adenocarcinoma."	( Akaike, K; Kaneko, K; Okubo, T; Saito, T; Suehara, Y; Takagi, T; Torigoe, T; Yao, T, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	4 (26.67)	12.5806
2000's	7 (46.67)	18.1394
2010's	2 (13.33)	28.8240
2020's	2 (13.33)	9.53

Drug	Relationship Strength	Studies
albendazole	low	1
khellin	low	1
titanium	low	2
gadolinium	low	1
camptothecin	low	1
buserelin	low	1
irinotecan	low	1
fluorodeoxyglucose f18	low	4
tamoxifen	low	2
goserelin	low	1
technetium tc 99m medronate	low	2

Protein Targets (321)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	2	0	0	2
Luciferase	2	0	0	2
glp-1 receptor, partial	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	3	0	0	3
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	4	0	0	4
TDP1 protein	6	0	0	6
GLI family zinc finger 3	4	0	0	4
AR protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	3	0	0	3
estrogen nuclear receptor alpha	2	0	0	2
polyprotein	4	0	0	4
67.9K protein	4	0	0	4
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
caspase-3	2	0	0	2
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Histone H2A.x	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
chromobox protein homolog 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	4	0	0	4
Vif	0	0	0	1
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	4	0	4
Interferon beta	6	0	0	6
Cellular tumor antigen p53	4	0	0	4
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Chain A, Cruzipain	1	0	0	1
DNA topoisomerase	0	1	0	1
thioredoxin reductase	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
PPM1D protein	3	0	0	3
Thrombopoietin	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
EWS/FLI fusion protein	3	0	0	3
glucocerebrosidase	2	0	0	2
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	7
DNA topoisomerase 2-alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Histone deacetylase 4	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
Histone deacetylase 7	0	1	0	1
GABA theta subunit	4	0	0	4
Histone deacetylase 2	0	1	0	1
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	4	0	4
Cytochrome P450 3A4	0	3	0	3
Alpha-2C adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
USP1 protein, partial	2	0	0	2
GALC protein	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, CES1 protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
acetylcholinesterase	2	0	0	2
phosphopantetheinyl transferase	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
arylsulfatase A	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
streptokinase A precursor	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Spike glycoprotein	0	0	1	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Cytochrome P450 2B1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (15)

Protein Targets (321)

Collagenous Fibroma

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (15)

Drugs Studied (13)

Protein Targets (321)