Chronic Progressive External Ophthalmoplegia

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)

Synonym
Graefe Disease
Ophthalmoplegia, Progressive External
Ocular Myopathy of Von Graefe-Fuchs
Graefe's Disease
Ocular Muscular Dystrophy
Ophthalmoplegia, Chronic Progressive External
Mitochondrial Ocular Myopathy
CPEO
Chronic Progressive External Ophthalmoplegia
Progressive External Ophthalmoplegia

Excerpt	Reference
"Autosomal dominant progressive external ophthalmoplegia is a mitochondrial disorder characterized by multiple large deletions of mitochondrial DNA."	( Fukazawa, T; Goto, Y; Houzen, H; Komaki, H; Nonaka, I; Yoshida, K, 2002)
"Autosomal recessive progressive external ophthalmoplegia is a mitochondrial disease characterized by accumulation of multiple large-scale deletions of mitochondrial DNA."	( Ceuterick, C; De Jonghe, P; Dehaene, I; Dermaut, B; Löfgren, A; Martin, JJ; Moonen, M; Tack, P; Van Broeckhoven, C; Van Goethem, G; Van Zandijcke, M; Ververken, D; Wibail, A, 2003)
"Autosomal dominant progressive external ophthalmoplegia is a common neurological presentation of mitochondrial disease and is characterised by multiple deletions of mitochondrial DNA in muscle."	( Blakely, EL; Deschauer, M; He, L; Kiefer, R; Taylor, RW; Turnbull, DM; Zierz, S, 2003)
"Chronic progressive external ophthalmoplegia is a mitochondrial disease, which is accompanied by accumulation of mitochondrial DNA (mtDNA) deletions caused by mutations in nuclear-encoded genes such as POLG (mtDNA polymerase)."	( Kasahara, T; Kato, T; Kubota, M; Miyauchi, T; Mouri, A; Nabeshima, T; Noda, Y, 2006)
"CPEO is associated with minimal EOM volume reduction despite clinically severe weakness."	( Bhola, R; Demer, JL; Ortube, MC, 2006)
"Chronic progressive external ophthalmoplegia is one of mitochondrial disorders, characterized by ptosis, limitation of eye movement, variably severe bulbar muscle weakness and proximal limb weakness."	( Chen, T; Cong, L; Fei, L; Liu, J; Luo, H; Pu, C; Shi, Q; Tang, W; Wang, Q; Yu, S, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (2.53)	23.3326
1990's	17 (21.52)	12.5806
2000's	43 (54.43)	18.1394
2010's	13 (16.46)	28.8240
2020's	4 (5.06)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	3	0
carnitine	medium	3	1
octanoic acid	low	1	0
malic acid	low	1	0
cytosine	low	1	0
lactic acid	medium	5	1
glycine	low	2	0
hydrogen	low	1	0
pyruvic acid	low	1	0
thiamine	low	2	0
thymine	low	1	0
acetazolamide	medium	1	1
bupivacaine	low	1	0
carbamazepine	low	1	0
chloral hydrate	low	1	0
valproic acid	low	1	0
ethidium	low	1	0
ethylmaleimide	low	1	0
propofol	low	1	0
corticosterone	low	1	0
prednisolone	low	2	0
prednisone	low	1	0
alanine	low	3	0
serine	low	1	0
aspartic acid	low	3	0
lysine	low	2	0
adenosine diphosphate	medium	3	1
uridine	low	2	0
levodopa	low	3	0
tyrosine	low	2	0
threonine	low	2	0
tryptophan	low	2	0
isoleucine	low	1	0
arginine	low	3	0
potassium cyanide	low	1	0
lithium carbonate	low	1	0
acetylcysteine	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
s-adenosylmethionine	low	1	0
propiconazole	low	1	0
remifentanil	low	1	0
thymidine 5'-triphosphate	low	1	0
fluorodeoxyglucose f18	medium	1	1
5,6-dihydrouridine	low	1	0
caprylates	low	1	0
proline	low	1	0
glycogen	low	1	0
acetyl coenzyme a	low	1	0
nadp	low	1	0
rottlerin	low	1	0
coenzyme q10	low	4	0
4-hydroxy-2-nonenal	low	1	0
cysteine	low	1	0
phosphorus	low	1	0
i(3)so3-galactosylceramide	low	1	0
beta-escin	low	1	0
phosphocreatine	medium	3	1
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	2	0
cytochrome c-t	low	2	0
humanin	low	1	0
ubiquinone	low	5	0
piperidines	low	1	0
tetracycline	medium	2	1
cyclosporine	low	1	0
digitonin	low	1	0
deoxyguanosine	low	4	0
guanine	low	3	0
didanosine	low	1	0
8-hydroxy-2'-deoxyguanosine	low	4	0
eye	low	7	0

Protein Targets (714)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent dopamine transporter	0	1	0	1
Microtubule-associated protein tau	6	0	0	6
vitamin D3 receptor isoform VDRA	5	0	0	5
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cytidine deaminase	0	2	0	2
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	7	0	0	7
GALC protein	2	0	0	2
GLI family zinc finger 3	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
glucocorticoid receptor [Homo sapiens]	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	16	0	0	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	6	0	0	6
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
Bloom syndrome protein isoform 1	9	0	0	9
thyroid hormone receptor beta isoform a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
geminin	10	0	0	10
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	2	1	5
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	9	0	9
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	4	1	14
Carbonic anhydrase 2	0	4	1	13
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	2	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	3
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	2	2	1	5
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	2	2	1	5
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	2	1	7
Carbonic anhydrase 6	0	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	2	2	1	5
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	2	2	1	5
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	2	2	1	5
Adenosine receptor A2a	0	1	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	1	8
Carbonic anhydrase	0	1	0	4
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	2	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-3	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-2	2	2	1	5
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	4	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	2	2	1	5
Canalicular multispecific organic anion transporter 1	0	6	0	6
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	1	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	8
N-alpha-acetyltransferase 50	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	4	0	0	4
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	8	0	0	8
RAR-related orphan receptor gamma	8	0	0	8
USP1 protein, partial	4	0	0	4
NFKB1 protein, partial	3	0	0	3
Thrombopoietin	3	0	0	3
AR protein	11	0	0	11
regulator of G-protein signaling 4	4	0	0	4
farnesoid X nuclear receptor	6	0	0	6
estrogen nuclear receptor alpha	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
D(1A) dopamine receptor	2	0	0	2
thyroid hormone receptor beta isoform 2	7	0	0	7
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	7	0	0	7
muscarinic acetylcholine receptor M1	5	0	0	5
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	7	0	0	7
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	10	0	0	10
pregnane X nuclear receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	2	1	4
Glutamate receptor 2	3	0	0	3
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	9
Proton-coupled amino acid transporter 1	0	5	0	5
Adenosine deaminase	0	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	7	0	0	7
DNA polymerase iota isoform a (long)	8	0	0	8
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
IDH1	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
Vpr	1	0	0	1
Bile salt export pump	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Cellular tumor antigen p53	9	0	0	9
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
progesterone receptor	6	0	0	6
nonstructural protein 1	4	0	0	4
G	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Inositol hexakisphosphate kinase 1	2	0	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
cytochrome P450 2C9, partial	2	0	0	2
Deoxycytidine kinase	0	0	0	1
67.9K protein	3	0	0	3
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
EWS/FLI fusion protein	3	0	0	3
cytochrome P450 2D6	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
activating transcription factor 6	3	0	0	3
Albumin	0	0	1	1
Reverse transcriptase/RNaseH	0	3	1	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Smad3	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
neuropeptide S receptor isoform A	2	0	0	2
Ghrelin O-acyltransferase	0	1	0	1
Monoglyceride lipase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Phosphatidylcholine-sterol acyltransferase	0	0	1	1
G-protein coupled receptor 1	0	0	1	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Luciferase	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Polyphenol oxidase 2	0	1	0	3
Epidermal growth factor receptor	0	1	0	1
Plasma kallikrein	0	0	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	1	0	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Glutathione reductase, mitochondrial	0	2	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
G-protein coupled receptor 84	0	1	1	2
Solute carrier family 22 member 11	0	1	0	2
luciferase	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	4	2	11
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	2	0	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
glp-1 receptor, partial	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
peroxisome proliferator activated receptor gamma	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Histone H2A.x	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, Cruzipain	1	0	0	1
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	1	0	0	1
DNA polymerase III, partial	1	0	0	1
polyprotein	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Eukaryotic elongation factor 2 kinase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Chymotrypsinogen B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
MAP kinase-activated protein kinase 2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Protein kinase C delta type	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
RuvB-like 1	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN	0	0	1	1
Chain A, ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN	0	0	1	1
Chain A, Deoxynucleoside kinase	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Protein cereblon	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Cocaine esterase	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Chronic Progressive External Ophthalmoplegia

Synonyms(10)

Research Excerpts

Overview

Research

Studies (79)

Protein Targets (714)

Chronic Progressive External Ophthalmoplegia

Synonyms(10)

Research Excerpts

Overview

Research

Studies (79)

Drugs Studied (77)

Protein Targets (714)