Page last updated: 2024-09-27

Choriocarcinoma, Non-gestational

A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.

Synonyms(2)

Synonym
Non-gestational Choriocarcinoma
Choriocarcinoma, Non-gestational

Research

Studies (23)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's9 (39.13)18.1394
2010's12 (52.17)28.8240
2020's2 (8.70)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
hexachlorocyclohexane0low10
fluorouracil0low10
ifosfamide0low10
etoposide0low160
fluorodeoxyglucose f180low20
methotrexate0low90
docetaxel anhydrous0low10
carboplatin0low20
dactinomycin0low50
levoleucovorin0low10

Protein Targets (347)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
acetylcholinesterase2002
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma5005
estrogen receptor 2 (ER beta)5005
G1001
cytochrome P450 2D61001
euchromatic histone-lysine N-methyltransferase 24004
vitamin D3 receptor isoform VDRA3003
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear factor erythroid 2-related factor 2 isoform 16006
DNA polymerase kappa isoform 12002
histone acetyltransferase KAT2A isoform 14004
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 1001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase3003
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
interleukin 82002
15-lipoxygenase, partial2002
hypoxia-inducible factor 1 alpha subunit4004
USP1 protein, partial2002
TDP1 protein7007
GLI family zinc finger 36006
Microtubule-associated protein tau3003
AR protein8008
caspase 7, apoptosis-related cysteine protease4004
aldehyde dehydrogenase 1 family, member A14004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha9009
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-34004
RAD510101
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x4004
Caspase-71001
Bloom syndrome protein isoform 12002
thyroid hormone receptor beta isoform a1001
caspase-31001
thyroid hormone receptor beta isoform 28008
huntingtin isoform 22002
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 224004
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 12002
caspase-1 isoform alpha precursor2002
Gamma-aminobutyric acid receptor subunit pi2002
Voltage-dependent calcium channel gamma-2 subunit5005
Cellular tumor antigen p537007
ATP-dependent translocase ABCB10307
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Nuclear receptor ROR-gamma1001
Caspase-72002
Spike glycoprotein4004
Gamma-aminobutyric acid receptor subunit alpha-12002
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
GABA theta subunit2002
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon2002
PPM1D protein1001
67.9K protein5005
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 22002
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Bile salt export pump0707
Serum paraoxonase/arylesterase 10404
Kinesin-like protein KIF110101
Canalicular multispecific organic anion transporter 10708
Nucleotide-binding oligomerization domain-containing protein 20202
glp-1 receptor, partial2002
SMAD family member 22002
SMAD family member 32002
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 23003
heat shock protein beta-12002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transactivating tegument protein VP16 [Human herpesvirus 1]0202
geminin6006
nuclear receptor coactivator 3 isoform a0202
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40101
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10202
UDP-glucuronosyltransferase 1A1 0102
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0114
Integrase 0101
Similar to alpha-tubulin isoform 1 0114
Similar to alpha-tubulin isoform 1 0103
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30405
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase2002
endonuclease IV1001
Skn7p0001
thioredoxin reductase3003
pregnane X receptor3003
ATAD5 protein, partial3003
Thrombopoietin1001
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein3003
nonstructural protein 11001
arylsulfatase A1001
IDH13003
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
flap endonuclease 12002
serine/threonine-protein kinase mTOR isoform 11001
Vpr1001
muscleblind-like protein 1 isoform 12002
lamin isoform A-delta105005
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1001
Thymidylate synthase0303
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Androgen receptor0101
Chain A, Beta-lactamase2002
GALC protein1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase2002
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
M-phase phosphoprotein 81001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0202
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10112
Carbonic anhydrase 20213
Thymidylate synthase0202
Integrin beta-31102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Genome polyprotein 0101
NPC intracellular cholesterol transporter 1 precursor1001
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Tyrosine-protein kinase Fyn0101
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Solute carrier organic anion transporter family member 1B10202
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]